4QEN,4NJ5,6A5N,6A5K


Conserved Protein Domain Family
SET_AtSUVH-like
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cd10545: SET_AtSUVH-like 
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins
Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.
Links
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Statistics
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PSSM-Id: 380943
Aligned: 10 rows
Threshold Bit Score: 352.476
Created: 26-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EHMT1 (3HNA) binds SAH and mono-methylated H3k9 peptide.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
4QEN_A    269 SGFTYIkSLIIEPnvi--ipkSSTGCNCr-gSCtd--skKCaCAKLNggnFPYVDLndGRLIEsrDVVFECGPHCGCg-p 342 thale cress
4NJ5_A    277 LYYEYLaQTSFPPglfvqqsgNASGCDCv-nGCg----sGClCEAKNs--GEIAYDynGTLIRqkPLIHECGSACQCp-p 348 thale cress
Q8GZB6    360 SGFTYIkSLIIEPnvi--ipkSSTGCNCr-gSCtd--skKCaCAKLNggnFPYVDLndGRLIEsrDVVFECGPHCGCg-p 433 thale cress
PNR32838  143 SSFEYTtKLRYPKgvs---lrSSTGCSCkgdSChsv-ghRCsCVLKNs-gKMLPYNqyGHLIRavPAVYECGSRCKCs-l 216 Physcomitrella patens
EER17214  179 DDRGPLvLAMTXXssk--ekeLREVEWNnraRVtlg-tsDCgRTSLC---SWGAYTknGYLKWtlDCIVECNFLCDCnyn 252 Perkinsus marinus ...
EFJ35186  227 DGYRYInKIEIDDgiv--lppPALGCSCk-gLCvd--pkTCsCAKRNghtFPYVDShgGRLAVplDAVYECGPNCGCg-p 300 Selaginella moelle...
Q9FF80    409 GPAYFTySTTVKYsesfklmqPSFGCDCa-nLCkpg-nlDChCIRKNg--GDFPYTgnGILVSrkPMIYECSPSCPCs-- 482 thale cress
Q8VZ17    529 KPPLFTyTVKLIYpdwc-rpvPPKSCCCt-tRCteaearVCaCVEKNg--GEIPYNfdGAIVGakPTIYECGPLCKCp-s 603 thale cress
6A5N_A    268 PLFTYTvKLIYPDwcr---pvPPKSCCCt-tRCteaearVCaCVEKNg--GEIPYNfdGAIVGakPTIYECGPLCKCp-s 340 thale cress
6A5K_A    268 PLFTYTvKLIYPDwcr---pvPPKSCCCt-tRCteaearVCaCVEKNg--GEIPYNfdGAIVGakPTIYECGPLCKCp-s 340 thale cress

Feature 1                            ###                #      #  ## #     ######  #          
4QEN_A    343 KCVNRtsQKRLRFNLEVFRSa-kKGWAVRSWEyIPAGSPVCEYIGVVRrTADVDTIs---dNEYIFEIDCQqtmqglggr 418 thale cress
4NJ5_A    349 SCRNRvtQKGLRNRLEVFRSl-eTGWGVRSLDvLHAGAFICEYAGVALtREQANILtm--nGDTLVYPARFssarwedwg 425 thale cress
Q8GZB6    434 KCVNRtsQKRLRFNLEVFRSa-kKGWAVRSWEyIPAGSPVCEYIGVVRrTADVDTIs---dNEYIFEIDCQqtmqglggr 509 thale cress
PNR32838  217 ECHNRvcQKGLRYRLEIFKTe-kKGWAVRSWDfIPSGGFVCEYTGVIMdTKTADELd---dDDYLFNLDFKqgnearwgv 292 Physcomitrella patens
EER17214  253 TCPLRvvQKGLTKRLEVFWTgreRGWGVRSLDvIKAGAFICEYAGELLpESVAETRgkelsDNYLFDLARHgagkmwkvg 332 Perkinsus marinus ...
EFJ35186  301 ACINRvtQRGLRYRLEVYKTq-hKGWAVRSWDsIPAGAPVCEYFGKVIkSDSLDVKs----DVYLFDLDCIqtmrgvdgr 375 Selaginella moelle...
Q9FF80    483 TCKNKvtQMGVKVRLEVFKTa-nRGWGLRSWDaIRAGSFICIYVGEAKdKSKVQQTma--nDDYTFDTTNVynpfkwnye 559 thale cress
Q8VZ17    604 SCYLRvtQHGIKLPLEIFKTk-sRGWGVRCLKsIPIGSFICEYVGELLeDSEAERRig--nDEYLFDIGNRydnslaqgm 680 thale cress
6A5N_A    341 SCYLRvtQHGIKLPLEIFKTk-sRGWGVRCLKsIPIGSFICEYVGELLeDSEAERRig--nDEYLFDIGNRydnslaqgm 417 thale cress
6A5K_A    341 SCYLRvtQHGIKLPLEIFKTk-sRGWGVRCLKsIPIGSFICEYVGELLeDSEAERRig--nDEYLFDIGNRydnslaqgx 417 thale cress

Feature 1                                                           #          #####       # #
4QEN_A    419 qrrlrdva---------------------------vpmnngvsqssedenapEFCIDAgSTGNFARFINHSCePNLFVQC 471 thale cress
4NJ5_A    426 dlsqvl--------------------------------adferpsypdippvDFAMDVsKMRNVACYISHSTdPNVIVQF 473 thale cress
Q8GZB6    510 qrrlrdva---------------------------vpmnngvsqssedenapEFCIDAgSTGNFARFINHSCePNLFVQC 562 thale cress
PNR32838  293 qrsdvf-------------------------------dsddsdmpplklsspKYVIDAsKFGGVARFVNHSCtPNLFVQC 341 Physcomitrella patens
EER17214  333 aagsqpprkkrstlagdlemetdlsgesyqcsaseddqsvgssscehdtrnsEFTIDAcYFGNVGRFVNHSCsPNLIIQR 412 Perkinsus marinus ...
EFJ35186  376 qfldyqngk--------------------------vscesrdaedaehhgqaEFCLDGgECGAVARFINHSCePNLFIQC 429 Selaginella moelle...
Q9FF80    560 pglade--------------------------------daceemseeseiplPLIISAkNVGNVARFMNHSCsPNVFWQP 607 thale cress
Q8VZ17    681 selmlg--------------------------------tqagrsmaegdessGFTIDAaSKGNVGRFINHSCsPNLYAQN 728 thale cress
6A5N_A    418 selmlg--------------------------------tqagrsmaegdessGFTIDAaSKGNVGRFINHSCsPNLYAQN 465 thale cress
6A5K_A    418 selxlg--------------------------------tqagrsxaegdessGFTIDAaSKGNVGRFINHSCsPNLYAQN 465 thale cress

Feature 1                 #               # #  
4QEN_A    472 VLSSHqdirLARVVLFAADNISPMQELTYDYGY 504 thale cress
4NJ5_A    474 VLHDHnslmFPRVMLFAAENIPPMTELSLDYGV 506 thale cress
Q8GZB6    563 VLSSHqdirLARVVLFAADNISPMQELTYDYGY 595 thale cress
PNR32838  342 VLYDHgdldLPHVMLFAGSDISPFQELTYDYGY 374 Physcomitrella patens
EER17214  413 VLVDThdyrLPRLALFAETDIDPLYELTYDYGY 445 Perkinsus marinus ATCC 50983
EFJ35186  430 VLSTHhdmrIPRIVLFAADNIAPLQELSYDYGY 462 Selaginella moellendorffii
Q9FF80    608 VSYENnsqlFVHVAFFAISHIPPMTELTYDYGV 640 thale cress
Q8VZ17    729 VLYDHedsrIPHVMFFAQDNIPPLQELCYDYNY 761 thale cress
6A5N_A    466 VLYDHedsrIPHVMFFAQDNIPPLQELCYDYNY 498 thale cress
6A5K_A    466 VLYDHedsrIPHVXFFAQDNIPPLQELCYDYNY 498 thale cress

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