2D8V


Conserved Protein Domain Family
Bbox1_ANCHR-like
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cd19817: Bbox1_ANCHR-like 
B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
ANCHR, also termed MLL partner containing FYVE domain, or zinc finger FYVE domain-containing protein 19, is a key regulator of the abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. The family also includes zinc finger B-box domain-containing protein 1 (ZBBX), a B-box motif containing protein with unclear biological function. The B-box motif of this family shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380875
Aligned: 28 rows
Threshold Bit Score: 61.9316
Created: 24-Sep-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:2D8V; Mus musculus ANCHR binds two Zn2+ ions through its B-box motif.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #       #  #         #  #    #           #     
2D8V_A         8 LPWCCiCNEDATLRCAGCDGDl----YCARCFREGHDNFDL----KEHQTSPY 52  house mouse
KIW65527     298 DTWCIiCSDNATLQCIGCDGDl----YCTNCWIEGHRGEAAgaeeRRHKAVQF 346 Phialophora americana
CEH15640     219 EGWCCiCNEDASLQCVGCDSDp----YCSQCWAEGHGGMDRde-lREHKTVPL 266 Ceraceosorus bombacis
POF13051     365 DSWCCiCNEDGEVRCLGCDGDi----YCQQCWREGHGNQPGq--eRGHRAVQY 411 Quercus suber
RJW68640     229 LPWCCiCNRNAQVRCVDCDGDl----FCNTCYRRNHRSGEE----KHHQSEPF 273 Clonorchis sinensis
XP_011402691 470 FPWCCmCNADAALKCFDCDNDl----YCVPCFSQGHEGFQL----FDHRYAPF 514 Amphimedon queenslandica
CBY09667      78 EKWCCiCNDDGSLRCHGCEEDv----FCQRCFKEQHKYYNI----TDHNYSRI 122 Oikopleura dioica
ODQ72257     403 DLGCCmCADDVEYRCLGCERLdedylYCSKCFLLSHLSEQAgydeRSHRYKKF 455 Lipomyces starkeyi NRRL Y-11557
CRG92200     368 TEFCCvCYDTATTKCLDCEGNq---fFCVRCWKEMHLGEEAiwadRIHNSVKY 417 Talaromyces islandicus
NP_573077    286 LPWCNiCNEDADFRCHGCGGEl----FCTLCYKECHDDDEEy---RAHVKEKY 331 fruit fly

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