Conserved Protein Domain Family
Bbox1_BRAT-like
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cd19813: Bbox1_BRAT-like 
B-box-type 1 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
BRAT is a NHL-domain family protein that functions as a translational repressor to inhibit cell proliferation. The family also contains Caenorhabditis elegans B-box type zinc finger protein ncl-1, a C. elegans Brat homolog which functions as a translational repressor that inhibits protein synthesis. BRAT contains Bbox1 and Bbox2 zinc fingers and NHL repeats. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380871
Aligned: 10 rows
Threshold Bit Score: 68.9728
Created: 17-Oct-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #            #  #    #  #   #        #     
Q8MQJ9        178 RCTACKSKcsd--avAKCFECQSyLCANCVTaHEFMHCFnGHNVCLI 222  fruit fly
P34611        131 HCSGCKSNet---atSFCQDCNAnLCDNCTMaHKFMHCFaDHRVVSL 174  Caenorhabditis elegans
KFM56989       97 VCTSCKAKet---avARCTECATfLCPNCVTaHQFMRCFeSHTVLSF 140  Stegodyphus mimosarum
EFX67294      140 ICTSCKANee---avAKCMDCDNlLCPNCYSaHKYMRCFdNHSVITF 183  common water flea
NP_001299928  131 HCSGCKSNetklqatSFCQDCNAnLCDNCTMaHKFMHCFaDHRVVSL 177  Caenorhabditis elegans
XP_025420010  130 VCKGCKNLntn--vvAYCYDCQQtLCANCMMaHQFMNCFeDHRLHGL 174  yellow sugarcane aphid
AUG84421      105 SCTGCKSKhll--avARCFDCPDfLCQDCERaHQYMKHFdGHRVISL 149  Dumeril's clam worm
EKC24514      110 HCTGCKSKetn--avARCFDCANfLCANCVMaHQFMHCFeGHRVASL 154  Pacific oyster
XP_006814798   39 ECGFCKRHea----sGFCSDCGVlICQSCAAhHRDANLLkKHAILTL 81   Saccoglossus kowalevskii
XP_002597426  170 HCQMCKSDak---veGRCADCSFlLCKNCITaHSNTPALkDHYIITL 213  Florida lancelet

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