Conserved Protein Domain Family
Bbox2_BRAT-like
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cd19798: Bbox2_BRAT-like 
B-box-type 2 zinc finger found in Drosophila melanogaster brain tumor protein (BRAT) and similar proteins
BRAT is a NHL-domain family protein that functions as a translational repressor to inhibit cell proliferation. This family also contains Caenorhabditis elegans B-box type zinc finger protein ncl-1, a C. elegans Brat homolog which functions as a translational repressor that inhibits protein synthesis. BRAT contains Bbox1 and Bbox2 zinc fingers and NHL repeats. The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif.
Links
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Statistics
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PSSM-Id: 380856
Aligned: 20 rows
Threshold Bit Score: 64.626
Created: 4-Sep-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C H C C C C H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens Midline-1 (2JUN) binds two Zn2+ ions through its B-box motif.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #    #        #  #    #  #     #     #     
Q8MQJ9        323 QRQLFCPR--HKQElLKFSCRTCCILVCKECIVl-EHSTg-lHELENV 366  fruit fly
XP_014773371  159 ERCVTCPK--HPYKvLQSFCVTCNIPVCKDCAIs-EHNSg--HDCQVL 201  Octopus bimaculoides
XP_011681095  176 DHSMLCPK--HADEkLKIFCVTCLEPVCHDCTLi-DHNReqgHQLQFL 220  purple sea urchin
PFX22950      748 RRPAFCPKdfHERKvLKFYCKVCQVPVCKNCLAl-EHCK---HDVEPL 791  Stylophora pistillata
XP_008107669  154 LQELYCQS--HPQEaLHFFCDTCSVPICRDCRMl-DHFQ---HKVVSM 195  green anole
NP_001259377  318 HKPVFCPQ--HVSEnLKYYCFTCQVPTCNDCLLs-DHKGs-dHHYETA 361  fruit fly
PVD34938      172 HKPVFCPK--HPEEnLKYFCDSCQVPICSECMIr-DHHQp-eHHYEKL 215  Pomacea canaliculata
XP_013416924  173 HKPLFCEI--HPVEgMKYFCNTCQTPICNECMVtnQHQG---HQIDRI 215  Lingula anatina
KFM56989      154 HKPVTCNS--HPDEvMKYYCHTCHVPICNECMIl-DHKQp-eHCYEKA 197  Stegodyphus mimosarum
ELT88189      163 HKPIFCNL--HTTEnLKYFCNTCQVPICNECMMa-EHRQp-eHKHERI 206  Capitella teleta

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