Conserved Protein Domain Family
CSTF1_dimer
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pfam16699: CSTF1_dimer (this model, PSSM-Id:374735 is obsolete and has been replaced by 465240)
Cleavage stimulation factor subunit 1, dimerization domain
This family is the dimerization domain, at the N-terminal, of a family of cleavage stimulation factor subunit 1 proteins from eukaryotes. This domain allows for homodimerization such that the functional state of CSTF1 is a heterohexamer. The cleavage stimulation factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognizes U and G/U-rich cis-acting RNA sequence elements and helps to stabilize the cleavage and polyadenylation specificity factor (CPSF) at the polyadenylation site as required for productive RNA cleavage.
Links
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Statistics
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PSSM-Id: 374735
Aligned: 26 rows
Threshold Bit Score: 76.0959
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EKC38324      11 VKNRELMYRLMISQLFYDGHQQLAVQLSNLVK-AHPACPPSDRLFKVVKFGLESEE 65  Pacific oyster
EEN42560      10 IKDREQLYKLVIGQLYYDGYESVAASLAKVVR-LQGALTPSDRLLRLTKLALVTEE 64  Florida lancelet
EDO32178       5 IKQRETLYKLIISQLHYDGCEAVAAALAKTTN-IISPCPPCARLLEIVNLGLAAEA 59  starlet sea anemone
EDV23894       5 VKNREQLYKLIISQLRYDGYEDIAALVGNTVN-TLETCAPSSKLFNIVSRSLSSES 59  Trichoplax adhaerens
CBY22946       5 VKDKDKLYRLIIGQLQFDGYIQVSKNLAQQAR-PSQGATPSDQLMKIFQAGLQTIe 59  Oikopleura dioica
EDQ85616      10 VGERHDLYRSMMQQLLADGHHDMAQQLAERLStDLGALSASSGLYDLFAASNQTSt 65  Monosiga brevicollis MX1
PDM82910       6 IKDRDSMYRLIIGQLYYDGHKQLALDLSNSIG-TKPPPPPSDKLFRLMSLVKQFAD 60  Pristionchus pacificus
XP_002126933   4 IKKRERMYRSIIGQLQNDGYMAIAKSLTSQVK-PFNPCTSSDFLFKAYSIGLEQVE 58  vase tunicate
XP_011616618   8 LKDRQHLYKLIISQLLYDGYISIANNLINEVK-PETVVSPSEQLMQLAKIGLENDD 62  torafugu
NP_495822      5 IKDREYMYRLIIGQLFYDGHQQIAVNLANTLGcSAPAPPPSDKLFRLVTIAKQFVE 60  Caenorhabditis elegans
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