Conserved Protein Domain Family
MMS19_N

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pfam14500: MMS19_N (this model, PSSM-Id:373098 is obsolete and has been replaced by 433995)
Dos2-interacting transcription regulator of RNA-Pol-II
This domain, along with the C-terminal part, pfam12460, is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly.
Statistics
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PSSM-Id: 373098
Aligned: 132 rows
Threshold Bit Score: 152.324
Created: 29-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEH55676        53 MESALVTTEDARRARGVLLLAESvagyasgapdgaddASRS-P-R-PLPASAANLLSQYFTSKLD--DFAVVRAALLGCA 127  Micromonas p...
XP_015781175    29 HGTALTSPNLDERTKGIETLAGY--------------IELLsP-G-SLGEIETEYLTEYLISRLSd-HHSFIPIIAKSLL 91   two-spotted ...
5_pfamImport     4 LGPHLTSADTQSRIEACKLLSNV--------------IQKL-P-KdCLNQQELASLVEFLCNRLKd-HYTLQPVVLDSLL 66  
Q95U54          44 LGFALSSPDMEERVAGTNLLSAV--------------LIAL-P-QdLLQERQLEFLSTFYMDRLRd-HHNVMPAIIDGID 106  fruit fly
Q4DE17          43 msRYLTDEKHIIEALFVLSLATT-------------------RrK-TLLDEEAVVVLKFFLEKLS--SLQTIETSVECIT 100  Trypanosoma ...
Q57YW3          40 MGKYLTGEEHVVNAVRVLGLATV-------------------NrR-DRTIEEVDVMLRFFSRKLS--SMQTIAVAVESTA 97   Trypanosoma ...
EFP11317        40 LSDFPDE-----REQTTEELIEV--------------ISKF-PnD-FLQKEEVSLLLDYFLNSIEssALTG-GAVIRGVH 97   Caenorhabdit...
11_pfamImport    1 ---MMISTHQSEREKAIKDISDV--------------ICTF-PpD-FLRKEEVHLLLQYFVESFDssAFSG-EAIIAALH 60  
XP_018666798    39 LGPHLTNKDTKIRIDACTLLSNV--------------IHKL-P-KdCLNQGELESLVQFLCSRLE--DHYTLQPVALSLL 100  vase tunicate
XP_001013640    64 MQFYFVNGREKTRQRATEFIYLF--------------FSRY-S-GlQMSQEEVESLYLFFLTKLF--DVATVKTANKVLL 125  Tetrahymena ...
EEH55676       128 AML-----------R--------------------ArvsvspeegtnpgsvphadpgamttttnpKTTPAVTrlaALD-- 174  Micromonas p...
XP_015781175    92 HLS-----------R--------------------F-----------------------------FPISNKQ---AIS-- 106  two-spotted ...
5_pfamImport    67 SIS-----------S--------------------A-----------------------------TNLAGEN---ATF-- 81  
Q95U54         107 ALV-----------H--------------------M-----------------------------KALPRAQ---IPQ-- 121  fruit fly
Q4DE17         101 RVIeylssqrpcskI--------------------V-----------------------------FTE------------ 119  Trypanosoma ...
Q57YW3          98 LLVrelssegpctsD--------------------V-----------------------------FNV------------ 116  Trypanosoma ...
EFP11317        98 HLV-------------------------------------------------------------------LKsknLPDnf 110  Caenorhabdit...
11_pfamImport   61 HLI-------------------------------------------------------------------VKsrhVPEnc 73  
XP_018666798   101 LQL-----------Ss-------------------A-----------------------------DNLTGEN---ACS-- 116  vase tunicate
XP_001013640   126 ELL-----------KnvikhqeqmkqkidskkagaF-----------------------------KEFKFNL---AKQ-- 160  Tetrahymena ...
EEH55676       175 ---MADRFFD-AVHVPSLVQADRQRSYELLIALL--S--H-AGAadepdavgpplgtstpSEqLECVVAACDGEKDPRCV 245  Micromonas p...
XP_015781175   107 ---IFTAIHR-EVANQQLPIQERFIIYQLIGSLFs-S--HlEAFksi-----------nnDF-LYGFIQIMEGERDPRCL 167  two-spotted ...
5_pfamImport    82 ---IISSIFK-EVHVQSCMQNERLKVFQILGTLLd-A--HsTTVsai-----------grDF-LYQYIQVIDSEQDPRNL 142 
Q95U54         122 ---ILQSFFE-HTTCQSQTRSDRTKLFHIFQYLTe-N--FqDELqam-----------agDF-VYGLINSIDGERDPRNL 182  fruit fly
Q4DE17         120 ---LANGFLP-NVRLQALPTRVRRSGFKILKYMVseAtvsw----------------lttPV-LCLLLEAMDEEGEPELV 178  Trypanosoma ...
Q57YW3         117 ---LHTEFLQ-SFSLQALPTNVRSWGYDVLRFTVtkEtatw----------------fttPF-LQVVLKSMDEENEPELL 175  Trypanosoma ...
EFP11317       111 evpLMRVLFK-EGNMQSWAQKERQLQYDILIWLLknKlqYlKCLg--------------pDF-LATYMKSVSGERDPRCL 174  Caenorhabdit...
11_pfamImport   74 etiLIRQLFK-ERDLQSWAQKERKLQFEILIWFLqnRieVlSAMg--------------dEF-LTIFIKNSSGERDPRCL 137 
XP_018666798   117 ---IITSVFK-EVHIQTCMQHDRLKIFQILGTLLd-I--HtKDVitm-----------grDF-LYQYIQVIDGEQDPRNL 177  vase tunicate
XP_001013640   161 ---FIEKISDsKFNISQYSQDVRDSVYINLRFLQe-N--FtESCvel-----------gaTY-VKVIIESTEDEKDPRCI 222  Tetrahymena ...
EEH55676       246 LLVCELFQALP-RAF--CgaegddaralskldahraafaAAAETLYDVVAAYFPVSFRP-P-P--GDVVRVTHEQLAATL 318  Micromonas p...
XP_015781175   168 LLCFDLFNKVV-SSLslG---------------------HLEEEIFAIVSCYFPIVYNP-T-K--EKGIQITRDDLHEAL 221  two-spotted ...
5_pfamImport   143 LVIFQLTKNLIdNGFplY---------------------DLTEELFEVSSCYFPIDFNP-AtA--GKKSTITNSDLVIAL 198 
Q95U54         183 DIIFSFMPEFL-STYplL---------------------HLAEEMFEIFACYFPIDFNP-S-K--QDPAAITRDELSKKL 236  fruit fly
Q4DE17         179 LHMFELYYFLS-FFVdkNni------------------vPLKEQYFDSISSYFPVVFSR-P-P--G--CSVTREELKRSL 233  Trypanosoma ...
Q57YW3         176 MRALELHHIIA-SYAreDam------------------qPLLEEYFDSISSYFPVVFSQ-P-P--G--CKVSKEDLRRVL 230  Trypanosoma ...
EFP11317       175 VHMFSSFLEVS-HNFalG---------------------PFTEDMFETIACYFPVEFRP-Q-K--NDT--ITREYLAASC 226  Caenorhabdit...
11_pfamImport  138 VQMFTAFLEVT-KSFslG---------------------PFAEDLFEVVACYFPVEFEP-Ek------YKITREYLSATC 188 
XP_018666798   178 LTIFQLTKNLIeSSFplF---------------------DLVEELFDVSSCYFPIDFNPaA-A--GKKSTITNLDLVSSL 233  vase tunicate
XP_001013640   223 IKSFKLIRFVL-ENFslSml------------------kPFLEDIFDNLECYYPIDFQP-D-PeqDKKYQISPKDLSEAL 281  Tetrahymena ...
EEH55676       319 RGAMCASSAYAPWAVPHVLESVDGsKPGL--VVDDALAALAACGSAF---GRRAMAPHMRATWGALRRVLL 384  Micromonas pusilla CC...
XP_015781175   222 KKCFMASSSFAPFAYLLFVEKLES-DVES--AKLDAYDMIISCTPVY----GKAVSSFLGSIWSAIRFDIL 285  two-spotted spider mite
5_pfamImport   199 RGVLASTPDFAPYCIPLLMEKLDS-DVES--AKIDSIETLTACLICY---GKNELETYLSTIWTSLKREIN 263 
Q95U54         237 TNCLVANNEFAEGTVVLAIEKLES-ELLV--AKLDSIELLHQAAVKF---PPSVLEPHFDQIWQALKTETF 301  fruit fly
Q4DE17         234 TRCMTC-PLYLDPCVSFTLSRLSS-PSSF--VKQESIAVLLELFSPEsahDMNDLSPHILPVVSHVRNEVI 300  Trypanosoma cruzi
Q57YW3         231 SACMTH-PLYLNICVPFLLSRMAS-PSSV--VKQESTNALLNIFSLDsshTTESLCPHVVSVTNHIRNEVv 297  Trypanosoma brucei
EFP11317       227 ASCLVSSPSFAPFCFLFIDEKLND-DDCSdeEYEDVLNLLIIACESF---PPQKNLSLLEPIIDGIRKVGL 293  Caenorhabditis remanei
11_pfamImport  189 ASCLVSSLSFSNFCYSFIDEKFSDeYSVE--EYNDILDLLILACNRF---PASKTMDHLECLLEGIRKGFL 254 
XP_018666798   234 RGVLASTKQFAQYCIPLMLEKLES-DVES--AKIDSLETLTACLGCY---GKQELEKYLSSLWSDVKREIN 298  vase tunicate
XP_001013640   282 DLCLINKHILQK-TLDIINEKINS-SYID--AKLAAMQTYQLVFKNY----------LPGQLLSSQRKQIL 338  Tetrahymena thermophi...
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