1NRJ


Conserved Protein Domain Family
SRX
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pfam09201: SRX (this model, PSSM-Id:370358 is obsolete and has been replaced by 370358)
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SRX, signal recognition particle receptor alpha subunit
Members of this family, which are predominantly found in eukaryotic signal recognition particle receptor alpha, consist of a central six-stranded anti-parallel beta-sheet sandwiched by helix alpha1 on one side and helices alpha2-alpha4 on the other. They interact with the small GTPase SR-beta, forming a complex that matches a class of small G protein-effector complexes, including Rap-Raf, Ras-PI3K(gamma), Ras-RalGDS, and Arl2-PDE(delta). Structurally the alpha subunit is SNARE-like.
Links
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Statistics
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PSSM-Id: 370358
Aligned: 12 rows
Threshold Bit Score: 190.284
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1NRJ_A         1 MFDQLAVFTPQGQVLYQYNCLGKKFSEIQINSFISQLITSPVTRKESVanantdgFDFNLLTINSEHKNS-------PSF 73  baker's yeast
CCE92569       1 MFEQFCIFTPQGDVIYQFNCAGKKFLESQINRFLSQYITSPAPNEETY-------KKYNLLSVSGGLSGPgvq--gpRGF 71 
XP_002555315   1 MIDQFVVFTLKGQVLYHFNPQGRKLAENHINKVISHLITSPSKKEES--------GKYLLFKL--------------DNF 58 
XP_003645496   1 MIDQLAIFTVQGQLLCKYNALGKKFSEQQFNKFIHTLIAQSIATSN---------SKFPTLSV--------------DSH 57 
Q6CTR2         1 MIDQFAVFTPAGNLLYGYNSLNKKFSETQINRFVSEFISQPVKDVT---------SKFPIIST--------------SDT 57  Kluyveromyces l...
XP_002498708   1 MLEQFVVFTSGGQVVYQFNCLGKKFAETQINRFISHLLSSPTIHNEDSs------RKYRIVEIAGNSNTSggnkaqsRGF 74 
XP_004178320   1 MFEQLAILTPQGTVLYQYNPLGKKFQEAQINAFINQLIVSPATKKDDIt------KKFSVFVVNSSVSSKks----vKNF 70 
CCC70743       1 MFDQLTIFTPQGQVLFKYNCQGKKFAELQINTFISKIITSPVTQRG---------SKFNILNITNDSLSKsn----vRPF 67 
CCD24063       1 MFEQLAIFTLQGIILYQYNCQGKKFSEHQINAFISKLITAPATRDTTTa-----gGKFTILNVTNDSTLSttn-aysRSF 74 
Q6FSE1         1 MFEQLTIFTPQGEVLYYYNCYDRKFAEAQVNAVISHLLTSPISRDHGS-------SKYKLLSIPSVSKNA-------KPF 66  [Candida] glabrata
XP_001646743   1 MFDQLVIFTPTGEVLYEYNPLNKKAMLNQVNAFISHLVNMPVSKKDDIn------SKLTIINVTQEKST--------RSF 66 
CCE63236       1 MFDQLAIFTPQGEVLYQYNPSGKKFAETQVNAFINHLMNSPISKKNDVh------SKFSLVNISPTVGDSsns--skLNF 72 

1NRJ_A        74 NALFYLNKQPELYFVVTFA-EQTLELNQETQQTLALVLKLWNSLHLSESILKNR-QGQNEKNKHNYVDILQGIEDDLKKF 151 baker's yeast
CCE92569      72 SAMFHISKQPELYYVVTYA-EQSLQLNEEAAEILRLSISLWNSLNVNEEIVRNL-SGRGSKNEHNFTDVVDGLDKDIETF 149
XP_002555315  59 AAACFIGKQPPLVYLVTYA-AQDLELNQEAEQVLDLGFGLWDSLKLNNSVLQNL-SGKGVKNRHNYTWILEGCDSNLNKF 136
XP_003645496  58 TFMFHETKQPFLYYVVSYSsSESLELNQEAEQVLNIAIKLWDSLGLNDAIRKNQdHAKSKKNRHNYTWLLEGAEDKLLQF 137
Q6CTR2        58 SYMYHETKQPHLFLVVSFAsSESIQLTAEAESVVVLATKLWESLGLNEVILDNI-SGKGKKNVHNFRFITEGASDQISKF 136 Kluyveromyces l...
XP_002498708  75 CSMYHVSRRPELYYVVTYA-EQSLQLNQEAEETLQVGINLWESLGLSEGVLDNI-NGKGSRNERNCIDVLTDLEEELEKF 152
XP_004178320  71 CAMFHVNKQPEIYFVVTYA-ELSLELNRDSEELLKLAIDLWDSLELSTSVSENLnQYKTNANEHSQVFILNDMEEDLSKY 149
CCC70743      68 CSMFHVTKQPELYFVITYA-EQTIDLDKEAEKTLDLALKLWDSLDLNEEIQSNL-------KNKQHVDILYGMNEDLSKF 139
CCD24063      75 CSMFYKTKQPEIYFVITYA-EQTIELDKEAEKTLDLATKLWNSLEINKSIQENL-------NSRDHIDILDGVNDGISKF 146
Q6FSE1        67 TVLSHVSKQPELYFIITYP-EPSMELNNEAQEVLDVAIALWDSLPINDIIIKAA-KGTGKKNAFNCIDISGEISEDIEKF 144 [Candida] glabrata
XP_001646743  67 SAMFHISKQPELYFVITYA-EQSLELNNEAESTLNLVLALWDSLDLNQSILENM-KGKSGKNEHNYCEVLQDLNETIKTF 144
CCE63236      73 SSMFYISKQPELYYLVTFP-EQKLDLKNEAEETLNLALSLWDSLGLNDSILQNLkNRTETKNWHNYIDLLYGTENDFKKF 151

1NRJ_A       152 EQYF 155 baker's yeast
CCE92569     150 DKYL 153
XP_002555315 137 DEYF 140
XP_003645496 138 EQFF 141
Q6CTR2       137 GSYF 140 Kluyveromyces lactis
XP_002498708 153 DQYL 156
XP_004178320 150 DKYL 153
CCC70743     140 DKYL 143
CCD24063     147 DQYF 150
Q6FSE1       145 DNYL 148 [Candida] glabrata
XP_001646743 145 DKYF 148
CCE63236     152 KEYF 155
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