2H11,3LCC


Conserved Protein Domain Family
TPMT

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pfam05724: TPMT (this model, PSSM-Id:368581 is obsolete and has been replaced by 399030)
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Thiopurine S-methyltransferase (TPMT)
This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines.
Statistics
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PSSM-Id: 368581
Aligned: 14 rows
Threshold Bit Score: 197.649
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H11_A    11 LTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTfLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQ 90  human
Q8Y274    13 AAPAFWDERFSRDHMPWDAHGVPPAFRQFCEA---QPAPLSTLIPGCGSAYEAGWLAERGWPVAAIDFAPSAVAS--AQA 87  Ralstonia solanacearum
Q9ZSZ7    32 VNSGGWEKCWVEEVIPWDL-GVPTPLVLHLVK-NNALPNGKGLVPGCGGGYDVVAMANPERFMVGLDISENALKKA-RET 108 Batis maritima
Q0WP12    31 VEEGGWEKCWEEEITPWDQGRATPLIVHLVDT--SSLPLGRALVPGCGGGHDVVAMASPERFVVGLDISESALAKANETY 108 thale cress
Q93V78    30 VEEGGWEKCWEDGITPWDQGRATPLVVHLVDS--SSLPLGRALVPGCGGGHDVVAMASPERFVVGLDISESALEKAAETY 107 wild cabbage
EGH42918   1 MKADFWLQRWSAGQIGFHQSEVNKDLQQYWSS-LNVVPGARVLVPLCGKSQDMSWLSGQGYHVVGAELSEAAVERYFTER 79  Pseudomonas syringa...
Q9I011     1 MQADFWHARWANNQIGFHLDEINPYLMRHLSR-LRLQAGEQILVPLCGKTLDLAWLAAQGLEVLGVELSEKAVSDFFEEH 79  Pseudomonas aerugin...
Q8PAT3     1 MDTDFWLQRWQDGQTGFHQDEVMPLLQKHWPA-LQLPAHARVLVPLCGKTLDLHWLAAQGHRVLGVEISPLAVTQFFDDA 79  Xanthomonas campest...
Q9KSN0     2 RDPEFWHNKWAANQIGFHLEDVNPLLIRFWSD-LAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH 80  Vibrio cholerae O1 ...
Q93JT2     4 HDNQRWLQLWRERRTDFHQHGVNLLLSRFWPAfAPATPS-RVFVPLCGKSLDMLWLAEQGHDVIGVELSPLAIEAFFREN 82  Pseudomonas stutzer...
2H11_A    91 NL-SyseEP--ITEIPGTKVfkSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQ- 166 human
Q8Y274    88 VL-G---PHagVVELADFFR---------------FT-PRQPV---QWIYERAFLCAMPRRLWADYATQVARLLPPGGLl 144 Ralstonia solanacearum
Q9ZSZ7   109 FStM---PN--SSCFSFVKE-------------DVFTWRPEQP--FDFIFDYVFFCAIDPKMRPAWGKAMYELLKPDGE- 167 Batis maritima
Q0WP12   109 GS-S---PK--AEYFSFVKE-------------DVFTWRPTEL--FDLIFDYVFFCAIEPEMRPAWAKSMYELLKPDGE- 166 thale cress
Q93V78   108 GS-S---PK--AKYFTFVKE-------------DFFTWRPNEL--FDLIFDYVVFCAIEPEMRPAWAKSMYELLKPDGE- 165 wild cabbage
EGH42918  80 GE-Q---PH--ITSQGDFKV--YAAPGIEIWCGDFFALTARDIGHCAAFYDRAAMIALPADMRERYVQHLEALMPQACS- 150 Pseudomonas syringa...
Q9I011    80 DL-H---PE--IDQLDGFRR--YRVAGITLLQGDFFALQAEHLAQCRAFYDRAALIALPPEMRERYAGHLQAVLPTRSL- 150 Pseudomonas aerugin...
Q8PAT3    80 GL-Q---PQ--RHTSRAGEH--CIAGPIEIICGDAFTLDASVLGDCTAVYDRAALVALPAALRQRYLETVYARLPAGCR- 150 Xanthomonas campest...
Q9KSN0    81 FY-T---PT--VTRLNAQHEl-YQFDELTLFTGDFFTAPVESV---DLVYDRAALVALPEEMRAEYAQRVLQLLKPGGR- 149 Vibrio cholerae O1 ...
Q93JT2    83 HL-----PP--SKRRQGRFTl-WRHGRIGILCGDYFALSEADLGPVDSVYDRAALTALPPILRSRYVAQLRRIVPDTAR- 153 Pseudomonas stutzer...
2H11_A   167 -YLLCVLSYDPTKHP-GPPFYVPH-----AEIERLFG-KICNIRCLEK-VDAFEE--RHKSWGIDCLFEKLYLL-TEK 232 human
Q8Y274   145 aGFFVVVDGRAAAPS-GPPFEITA-----QEQEALLS-PA-----FERiADALVP--ENESIPVFAGRERWQVW-RRR 207 Ralstonia solanacearum
Q9ZSZ7   168 ---LITLMYPITNHEgGPPFSVSE-----SEYEKVLVpLGFKQLSLED-YSDLAVepRKG-------KEKLARW-KKM 228 Batis maritima
Q0WP12   167 ---LITLMYPITDHVgGPPYKVDV-----STFEEVLVpIGFKAVSVEEnPHAIPT---------------------RK 215 thale cress
Q93V78   166 ---LITLMYPITDHD-GGPPY--------------------KVAVSTY-EDVLVPv-GFKA---VSIEENPYSIaTRK 214 wild cabbage
EGH42918 151 -GLLITLEYDQALLE-GPPFSVPQ-----TWLHRVMS-GNWEVTKVGG-QDTLHSsaRGLKAGLERMDEHVYVL-ERV 218 Pseudomonas syringae ...
Q9I011   151 -GLLVTIDYPQAEMA-GPPFAVPD-----EEVRGYYA-GGWRIEELER-GDVLGVnwKFLERGVSWLDEAVYLL-ERG 218 Pseudomonas aeruginos...
Q8PAT3   151 -GLLITLDYPQAEKA-GPPFSVDA-----AEVHALFG-TQWKVQELEH-RDILDQepRFRADGVTALSTGVYRL-QRD 218 Xanthomonas campestri...
Q9KSN0   150 -ILLVSMDYVQTELS-GPPFSVPE-----AEIRTLFM-GC-EVRRVYQdTSIDPHlnKRTQAGLSRFAEEVWVI-EKS 217 Vibrio cholerae O1 bi...
Q93JT2   154 -VFLLTLEDAEADAT------LQQalgvdEELAALYT-AGFEIALAHV-ESLFEPdpQNGA--PRRVEHKVYQL-TGK 219 Pseudomonas stutzeri ...
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