Conserved Protein Domain Family
DEXXQc_Mov10L1
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cd18078: DEXXQc_Mov10L1 
DEXXQ-box helicase domain of Mov10L1
Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350836
Aligned: 9 rows
Threshold Bit Score: 326.248
Created: 19-Sep-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structures of other Upf1-like helicase family members with bound ATP or ATP analogs
  • Comment:Walker A motif or motif I
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                       ######                                             
Q99MV5        746 VLNENQKLAVRRILSgdcrPLPYILFGPPGTGKTVTIIEAVLQVHYalp---------------dsRILVCAPSN--SAA 808  house mouse
NP_001072624  800 LLNNHQKLAVKRILGgecrPTPYILFGPPGTGKTVTIIEAILQIYYalp---------------dsRILVCAPSN--SAA 862  western clawe...
EFX68520      199 CLNREQRRAVLRILEgvhrPIPYIIYGPPGTGKTVTVVEAILQVFLlcp---------------rsRILVATPSN--SSA 261  common water ...
EFZ21228      855 QLNYYQKEAVKNIILglarPLPYVIFGPPGTGKTVTICETILQLLTtip---------------esRLLVATPSN--SSA 917  red fire ant
XP_001947174  545 KLNSEQKNAVINIMKgegrPMPYIIYGPPGTGKTITMTESIIQVYKefp---------------ksKLLICAPTN--SAV 607  pea aphid
CAG08644      506 DLNPLQREAVKRILAgecrPIPYVLFGPPGTGKTITIIEAILQVQYshlsqylelgqfsrttsprlRFQPINPTPspLAC 585  spotted green...
XP_002399427    1 DLNELQQTAVRDILGgvsgQLPYIVWGPPGTGKTVTLVETILQIVLnlk---------------hsRVLACAPSN--SAA 63   black-legged ...
Q9BXT6        744 VLNENQKLAVKRILSgdcrPLPYILFGPPGTGKTVTIIEAVLQVHFalp---------------dsRILVCAPSN--SAA 806  human
NP_001246603  663 SLNSIQKRAVFNILRgeaeNIPYVLFGPPGSGKTMTLIETLLQLVRnlp---------------gaRILVGTPSN--SSA 725  fruit fly

Feature 1                                                                                         
Q99MV5        809 DLVCLRLHESkvpkpaAMVRVNATcrfeetiidaikp-----------------------ycrdgediwrasrFRIIITT 865  house mouse
NP_001072624  863 DLVCLRLHQSnqlepgSMVRVNATcrleetvcdavrp-----------------------ycgpgedirkasrFRIIIST 919  western clawe...
EFX68520      262 DLIAHRLHESgrvsvgELVRLNAFsrnidtmpeaiqr-----------------------ycmtcdelqkairHRILVTT 318  common water ...
EFZ21228      918 NLIAERLLDSnilkpgDMVRLIAHhcldsdyiperllpycataelaae-gtvdrfqhhengvrlnctmsvlgrHRITIGT 996  red fire ant
XP_001947174  608 DMLLSKLVNCglfdktIMKRLVSYnhfigtsydmdydeycalpel-------essyhggesdtklirkhdilkLRIVLST 680  pea aphid
CAG08644      586 SNWTPRCTTFcpiavfWCAHLPTVlqtssa--------------------------------------sasirADSCTLQ 627  spotted green...
XP_002399427   64 DLLVSARTPRlwirlgQAAKVRKVtmrqvmtsgirhl------------------------clstesletasrRRIVVAT 119  black-legged ...
Q9BXT6        807 DLVCLRLHESkvlqpaTMVRVNATcrfeeividavkp-----------------------ycrdgediwkasrFRIIITT 863  human
NP_001246603  726 DLVTKRLIDSkallqgDFIRLVSYnqvekdlippeimsycatsdvgavgscedkmmvtesglklrcqakfigtHRITIST 805  fruit fly

Feature 1                                                                 #                       
Q99MV5        866 CSSAGLFYqigvrvgyfTHVFVDEAGQASEPEcliplg--lisdinGQIVLAGDPMQLGPViksrl-amayGLNVSMLER 942  house mouse
NP_001072624  920 CSSAGMFYqiglrvghfTHVFVDEAGQASEPEcliplg--lisevtGQIILAGDPMQLGPIiksrv-slayGLNVSFLER 996  western clawe...
EFX68520      319 CTTSGKVYtmclqighfTHLFIDEAGQATEPEtlvsvglircdsnpGQIILAGDPKQLGPVlmsqh-sssyGLSLSLLER 397  common water ...
EFZ21228      997 CSALGILYnmgfprghfSHILVDEAGQATEPEimipln--fihsdnGQVILAGDPMQLGPVvmskl-alffGFGESFLSR 1073 red fire ant
XP_001947174  681 EGTAGLLYmmglksgtfTHIFIDEAGQSTEPDillplsf-ldpyrdGQVILAGDPKQLGPVvmsllakhsgGLGLSMLCR 759  pea aphid
CAG08644      628 VWLESTRQvgrrrvghfTHVFLDEAGQATEPEsripis--fiserdGQIILAGDPCQLGPViksks-aaafGLGVSMLER 704  spotted green...
XP_002399427  120 VITAGSLYslglppdhfTHGFLDEAGQATEPEslvalg--lvslggGSLVLGGDPLQLGPVirsrl-atrgGLGTSLLER 196  black-legged ...
Q9BXT6        864 CSSSGLFYqigvrvghfTHVFVDEAGQASEPEcliplg--lmsdisGQIVLAGDPMQLGPViksrl-amayGLNVSFLER 940  human
NP_001246603  806 CTTLGNFLqlgfpaghfTHVLFDEAGQCTEPEtmvpiv--mltkkrSQVVLSGDPRQLQSIvtsri-askmGFSISFLER 882  fruit fly

Feature 1                                             ##
Q99MV5        943 LMsrpaylrden-----afgacgaynpLLVTKLVKNYR 975  house mouse
NP_001072624  997 LMarplylrdee-----sygacgnynpLLITKLMKNYR 1029 western clawed frog
EFX68520      398 LSnnplysrnks------fadsghynpNLLTKLVRNYR 429  common water flea
EFZ21228     1074 LLqqfpyqrdp-------egfetcydpRLVTKLVMNYR 1104 red fire ant
XP_001947174  760 FInypsylrdtd-----mfpehngynpKLITHLVENYR 792  pea aphid
CAG08644      705 LManplysr-----------hdwgynpRLVTKLVDNYR 731  spotted green pufferfish
XP_002399427  197 LVltnercpvpvtqlrnrcvqkrllflMLNRALLDPYS 234  black-legged tick
Q9BXT6        941 LMsrpayqrden-----afgacgahnpLLVTKLVKNYR 973  human
NP_001246603  883 LLerspyrkdlq-----rfpessgynpLVLTKLLYNYR 915  fruit fly

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