1S2M,1VEC,4BRU,4CT4


Conserved Protein Domain Family
DEADc_DDX6

?
cd17940: DEADc_DDX6 
Click on image for an interactive view with Cn3D
DEAD-box helicase domain of DEAD box protein 6
DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Statistics
?
PSSM-Id: 350698
Aligned: 20 rows
Threshold Bit Score: 278.798
Created: 30-Jan-2014
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on structures of other members of the DEAD-box helicase family with bound ADP/AMP

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                      ## ###  #                 ########                             
1S2M_A     23 FEDFYLKRELLMGIFEaGFEKPSPIQEEAIPVAITGRDILARAKNGTGKTAAFVIPTLEKVkpklnkIQALIMVPTRELA 102 baker's yeast
4CT4_B      7 FEDYCLKRELLMGIFEmGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLdlkkdnIQAMVIVPTRELA 86  human
CAK68494   39 FEEFDLKQELMQGLAAaNYEKPSPIQEESIPFALAGSNIIARAKNGTGKTGAYIIPILEMLeme-gqIQSLILVPTRELA 117 Paramecium tetraur...
CCA22119   45 FEDYFLKRELLMGIFEkGFEHPSPIQEEAVPIILAGRNVMARAKNGTGKTAAFIIPCLEKTetskkhIQVLILVPTRELA 124 Albugo laibachii Nc14
CBK23681   36 FEKYGLKEEIMKVLCEkGWERPSPVQSQTIPSILSGKDILARSKNGTGKTGAYVIPCMNQIdpkervIQVLILVPARELA 115 Blastocystis hominis
EAN77819   33 FEEYGLRRELQMGIFEkGFERPSPVQEEAIPVALQGKDVLARAKNGTGKTASFVIPVLEKVdtqlphIQALLMVPTRELA 112 Trypanosoma brucei
Q54E49     51 FDDLHLKRDLLRGIFEkGYVKPSPIQEKAIPIALAGRDIMARAKNGTGKTASFLIPALEKTdptkdvIQVLILVPTRELA 130 Dictyostelium disc...
Q8RXK6    133 FEDYFLKRELLMGIYEkGFERPSPIQEESIPIALTGRDILARAKNGTGKTAAFCIPVLEKIdqdnnvIQAVIIVPTRELA 212 thale cress
1174456    46 FEDYYLKRELLMGIFEaGFERPSPIQEESIPIALSGRDILARAKNGTGKTAAFVIPSLEKVdtkkskIQTLILVPTRELA 125 Schizosaccharomyce...
EGD76741   26 FEDYGLKRDLQKGIYQlGFERPTPIQEESISEVLLGHDILARAKNGTGKTGAYLVPMLNRIdvdnpaVQALVLVPTRELS 105 Salpingoeca sp. AT...
Feature 1                                                                                     
1S2M_A    103 LQTSQVVRTLgkh-cgISCMVTTGGTnLRDDILRLneTVHILVGTPGRVLDLASRKvaDLSDCSLFIMDEADKMLSRDFK 181 baker's yeast
4CT4_B     87 LQVSQICIQVskhmggAKVMATTGGTnLRDDIMRLddTVHVVIATPGRILDLIKKGvaKVDHVQMIVLDEADKLLSQDFV 166 human
CAK68494  118 LQVSSLVKDIgky-mkVECMVSTGGTdFKEDIYRLkqVVHVLVGTPGRILDLAQRKlaDLSKLKHFVLDEADKLLSVDFQ 196 Paramecium tetraur...
CCA22119  125 LQTSAIVKEIgkh-mgVECMVSTGGTsLKDDIMRLynTVHILVGTPGRIMDLANKGvaDLSNCSTVIMDEADKLLSPEFQ 203 Albugo laibachii Nc14
CBK23681  116 LQTSRVVREFgka-lkVDSMCCFGGQpLADDLYRLrrGVHVLVGTAARILDITRRGhcDLSHCKYLVLDEADKMLSDNFR 194 Blastocystis hominis
EAN77819  113 LQTAQVTKELgkhitgLEVMVTTGGTtLRDDILRLqsVVHVLVATPGRAVDLASKGtaKLDHCRIIVLDEADKLLSQEFT 192 Trypanosoma brucei
Q54E49    131 LQTSQVCKELgky-mnVQVMASTGGTsLKDDIMRLynPVHILVATPGRVLDLAQKNvaNLSNCHTMIMDEADKLLSQEFQ 209 Dictyostelium disc...
Q8RXK6    213 LQTSQVCKELgkh-lkIQVMVTTGGTsLKDDIMRLyqPVHLLVGTPGRILDLTKKGvcVLKDCSVLVMDEADKLLSQEFQ 291 thale cress
1174456   126 LQTSQVCKTLgkh-mnVKVMVTTGGTtLRDDIIRLndTVHIVVGTPGRVLDLAGKGvaDFSECTTFVMDEADKLLSPEFT 204 Schizosaccharomyce...
EGD76741  106 LQTSKTAKDLgkf-lnIQVVCTTGGTsVRDDILRFksTVHLVVGTPGRVLDLLDRGviRSAEIEMVVLDEADKLLDRTFQ 184 Salpingoeca sp. AT...
Feature 1                                                
1S2M_A    182 TIIEQILSFLPp-THQSLLFSATFPLTVKEFMVKHLHKPYEIN 223 baker's yeast
4CT4_B    167 QIMEDIILTLPk-NRQILLYSATFPLSVQKFMNSHLQKPYEIN 208 human
CAK68494  197 PLIVKILQFAPp-EVQIMMFSATFPVDVKGFINEHVPQIQEIN 238 Paramecium tetraurelia
CCA22119  204 PLLEQLLNHTAk-KRQICLFSATFPVTVKAFKDRFIENPYEIN 245 Albugo laibachii Nc14
CBK23681  195 QVVEDLIAYLPa-EHQTLLLSATFPSTVRSFAAEYMHEPVMIN 236 Blastocystis hominis
EAN77819  193 SLMRDLYGFLPk-GRQSLLFSATFPVTVKDFADKYLRNPYEIN 234 Trypanosoma brucei
Q54E49    210 PLVEQLINFLPq-QRQILLFSATFPVTVKSFKEHYLQQAFEIN 251 Dictyostelium discoideum
Q8RXK6    292 PSVEHLISFLPe-SRQILMFSATFPVTVKDFKDRFLTNPYVIN 333 thale cress
1174456   205 PIIEQLLSYFPk-NRQISLYSATFPLIVKNFMDKHLNKPYEIN 246 Schizosaccharomyces pombe 972h-
EGD76741  185 RNITRIISYLPrqDKQLMLFSATFPQSVKDFTRRYMRQPKKIN 227 Salpingoeca sp. ATCC50818

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap