Conserved Protein Domain Family
BACK_KLHL31_KBTBD1
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cd18470: BACK_KLHL31_KBTBD1 
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31)
KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).
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Statistics
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PSSM-Id: 350545
Aligned: 6 rows
Threshold Bit Score: 208.576
Created: 5-Oct-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9H511       167 MSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLqLPSEIVAFQIAMKWLEFDqK 246 human
XP_018121042 167 MNVENCMYVANIAETYGLKSTKEAAQKFIRDNFIEFSETDQFLKLTFDQINELLIDDYLqLPSEIVAFQIAMKWLDFDeK 246 African clawed ...
Q6Q7X9       168 TSVENCMYVVNIADTYNLKETKEAAQKFMRENFIEFSEMEQFLKLTYEQINEFLTDDSLqLPSELTAFQIAVKWLDFDeK 247 zebrafish
EMC90236     167 INVENCMYVANIAETYGLKTTKEAAHKFIRDNFIEFSETDQFLKLTFDQINELLADDDLqLPSEIVAFQIAIKWLEFDqK 246 rock pigeon
XP_007892245 167 INVENCMYIVNIAETYGLRNTMEAAHNFIRDHFIEFSEKDQFLKLTFEQIIKFMMDDALlLPSEITAFQIAMKWLDFDsK 246 elephant shark
XP_006012670 167 ITVANCMYIANIAETYGLRNTKEAAQKFIRDNFIEFSETDQFLKLTFDQINEFLIDDTLqLPSEVTAFQIAMKWLDFDqK 246 coelacanth

Q9H511       247 RVKYAADLLSNIRFGTIS 264 human
XP_018121042 247 RIKYASGLLSNIRFGTIS 264 African clawed frog
Q6Q7X9       248 RLKYAPDLLSNIRFGTIT 265 zebrafish
EMC90236     247 RVKFAADLLGNIRFGTIS 264 rock pigeon
XP_007892245 247 RAKYAADLLSTIRFCTIS 264 elephant shark
XP_006012670 247 RMKYVGDLLSNIRFGTIS 264 coelacanth
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