2NZ6,2PI7,2H03,3S3E,4IKC


Conserved Protein Domain Family
R3-PTPc
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cd14548: R3-PTPc 
catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar proteins
R3 subfamily receptor-type phosphotyrosine phosphatases (RPTP) are characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. Vertebrate members include receptor-type tyrosine-protein phosphatase-like O (PTPRO), J (PTPRJ), Q (PTPRQ), B (PTPRB), V (PTPRV) and H (PTPRH). They belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Most members are PTPs, except for PTPRQ, which dephosphorylates phosphatidylinositide substrates. PTPRV is characterized only in rodents; its function has been lost in humans. Both vertebrate and invertebrate R3 subfamily RPTPs are involved in the control of a variety of cellular processes, including cell growth, differentiation, mitotic cycle and oncogenic transformation.
Links
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Statistics
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PSSM-Id: 350396
Aligned: 10 rows
Threshold Bit Score: 386.325
Created: 29-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitecatalytic site
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 12 residue positions
Conserved feature residue pattern:x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on binding of human R-PTP-beta to inhibitors
  • Structure:2H03: Human R-PTP-beta binds non-peptidic inhibitor; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #                                                                            
2NZ6_A         75 RYNNVLPYDISRVKlsvqt-----hstddYINANYMPGyhskkDFIATQGPlpntlkDFWRMVWEKnvYAIIMLTKCveq 149  human
2PI7_A         63 RYTNILPYDFSRVRlvsmne----eegsdYINANYIPGynspqEYIATQGPlpetrnDFWKMVLQQksQIIVMLTQCnek 138  chicken
XP_002737773  236 RYTNILPYDHTRVKliemneddeedigstYINANYISGytsprEYIATQGPlpttkdDFWRMIWEQntQTIVMITRCvek 315  Saccoglossus ...
2H03_A         58 RYNNILPYDATRVKlsg---------gsdYINASYIPGnnfrrEYIVTQGPlpgtkdDFWKMVWEQnvHNIVMVTQCvek 128  human
3S3E_A         75 RFTNILPYDHSRFKlqpvdd----degsdYINANYVPGhnsprEFIVTQGPlhstrdDFWRMCWESnsRAIVMLTRCfek 150  fruit fly
4IKC_A         53 RFPNIKPYNNNRVKliadas----vpgsdYINASYISGylcpnEFIATQGPlpgtvgDFWRMVWETraKTLVMLTQCfek 128  human
P70289       1179 RYPHVLPYDHSRVRltqlsg----ephsdYINANFIPGyshpqEIIATQGPlkktveDFWRLVWEQqvHVIIMLTVGmen 1254 house mouse
Q9HD43        849 RYRNVLPYDWSRVPlkpihe----epgsdYINASFMPGlwspqEFIATQGPlpqtvgDFWRLVWEQqsHTLVMLTNCmea 924  human
KFM77963     1187 RFTNILPYDHSRVKlmpsdd----degsdYINANYIPGynsprEFIVTQGPlhstrdDFWRMIWEQncRAIVMLTRCvek 1262 Stegodyphus m...
XP_018672020 2128 RTAKLVPFDHCRVKiegipa----vegsnYINASYVPGphspeQYVATQTPldhtkkDFWRLIWETgsNTIVMLCNVmeg 2203 vase tunicate

Feature 1                                                                        ##               
2NZ6_A        150 grTKCEEYWPskqaq--dygdITVAMTSEIVLpeWTIRDFTVKniqt-sesHPLRQFHFTSWPDHGVPd--tTDLLINFR 224  human
2PI7_A        139 rrVKCDHYWPftedp-iaygdITVEMLSEEEHtdWVYRNFRISyad---evQDVMHFNYTAWPDHGVPtanaAESILQFV 214  chicken
XP_002737773  316 gkVRCDHYWPfdsdp-teygdITITMASESVLpeWTVRDFTLElkr---evRSLRHFQFTAWPDHGALg--rTDLLLRFV 389  Saccoglossus ...
2H03_A        129 grVKCDHYWPadqds-lyygdLILQMLSESVLpeWTIREFKICgeeqldahRLIRHFHYTVWPDHGVPe--tTQSLIQFV 205  human
3S3E_A        151 grEKCDQYWPndtvp-vfygdIKVQILNDSHYadWVMTEFMLCrgs---eqRILRHFHFTTWPDFGVPn--pPQTLVRFV 224  fruit fly
4IKC_A        129 grIRCHQYWPednkpvtvfgdIVITKLMEDVQidWTIRDLKIErhg---dcMTVRQCNFTAWPEHGVPe--nSAPLIHFV 203  human
P70289       1255 grVLCEHYWPvnstp-vthghITTHLLAEESEdeWTRREFQLQhgae-qkqRRVKQLQFTTWPDHSVPe--aPSSLLAFV 1330 house mouse
Q9HD43        925 grVKCEHYWPldsqp-cthghLRVTLVGEEVMenWTVRELLLLqvee-qktLSVRQFHYQAWPDHGVPs--sPDTLLAFW 1000 human
KFM77963     1263 grEKCDHYWPydtqp-ayygdIQVTILNESQYskWTISEFKVSrgd---qsRIIRHFHFTTWPDFGVPd--pPQTLVKFV 1336 Stegodyphus m...
XP_018672020 2204 gkKRCSEYWPkkqte--yfgnLAIQMTKQDVCkdWIVRHFSVTmrd---kvRHVTQFQFMNWSVVEQGn---PLPLVRFI 2275 vase tunicate

Feature 1                            #######                                       #          
2NZ6_A        225 YLVRDYmkqsppesPILVHSSAGVGRTGTFIAIDRLIYQIene--ntvDVYGIVYDLRMHRPLMVQTEDQYVFLNQ 298  human
2PI7_A        215 QMVRQKsvk--skgPMIIHCSAGVGRTGTFIALDWLLQHIrdh--efvDILGLVSDMRSYRMSMVQTEEQYIFIHQ 286  chicken
XP_002737773  390 RTVRGQipr--nagPTIVHCSAGVGRSGTFVAFDFVLQHLarkenkfiDIFGVVARMRQQRCYMVQTEAQYVFIHK 463  Saccoglossus kowa...
2H03_A        206 RTVRDYinrspgagPTVVHCSAGVGRTGTFIALDRILQQLdsk--dsvDIYGAVHDLRLHRVHMVQTECQYVYLHQ 279  human
3S3E_A        225 RAFRDRiga--eqrPIVVHCSAGVGRSGTFITLDRILQQInts--dyvDIFGIVYAMRKERVWMVQTEQQYICIHQ 296  fruit fly
4IKC_A        204 KLVRASrah--dttPMIVHSSAGVGRTGVFIALDHLTQHIndh--dfvDIYGLVAELRSERMCMVQNLAQYIFLHQ 275  human
P70289       1331 ELVQEEvkatqgkgPILVHCSAGVGRTGTFVALLPAVRQLeee--qvvDVFNTVYILRLHRPLMIQTLSQYIFLHS 1404 house mouse
Q9HD43       1001 RMLRQWldqtmeggPPIVHCSAGVGRTGTLIALDVLLRQLqse--gllGPFSFVRKMRESRPLMVQTEAQYVFLHQ 1074 human
KFM77963     1337 RTFRDRipp--dnkPVVVHCSAGVGRSGTFIALDHILQKIqkh--dyvDIFAIVYEMRKERVWMVQNEQQYICIHQ 1408 Stegodyphus mimos...
XP_018672020 2276 KSYRTTrhn--eykPTIVMCSNGSGRSGVFIGLDKIVDTMts----yiDVFGTVASLRKYRPFMVQTLTEYIVMHQ 2345 vase tunicate

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