1VKD,3WAS,5B0P,5B0S,4ONZ,5A7V


Conserved Protein Domain Family
GH130

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cd18607: GH130 
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Glycoside hydrolase family 130
Members of the glycosyl hydrolase family 130, as classified by the carbohydrate-active enzymes database (CAZY), are phosphorylases and hydrolases for beta-mannosides, and include beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281), beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319), beta-1,4-mannosyl-N-acetyl-glucosamine phosphorylase (EC 2.4.1.320), beta-1,2-mannobiose phosphorylase (EC 2.4.1.-), beta-1,2-oligomannan phosphorylase (EC 2.4.1.-) and beta-1,2-mannosidase (EC 3.2.1.-). They possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Beta-1,4-mannosylglucose phosphorylase is involved in degradation of beta-1,4-D-mannosyl-N-acetyl-D-glucosamine linkages in the core of N-glycans; it produces alpha-mannose 1-phosphate and glucose from 4-O-beta-D-mannosyl-D-glucose and inorganic phosphate, using a critical catalytic Asp as a proton donor.
Statistics
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PSSM-Id: 350119
Aligned: 16 rows
Threshold Bit Score: -1
Created: 11-Dec-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitechemical
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 4 residue positions
Conserved feature residue pattern:[DEN] [DEN] [FY] [DEN]Click to see conserved feature residue pattern help
Evidence:
  • Comment:conservative active-site residues (invariant sites among close relatives of 4-O-beta-D-mannosyl-D-glucose phosphorylase/MGP)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                                                        
1VKD_A     51 PKGARVFNSAVVPYng--eFVGVFRIdhkn-------------------------------------------------- 78  Thermotoga maritim...
3WAS_A     66 IGMNATLNAGAIKWdg--kYLMLVRVegad-------------------------------------------------- 93  Bacteroides fragil...
5B0P_A     24 FEVIGAFNGGVAEYng--eVLLLLRVaekpvsedpeivlapvynaknkelelqsfrlddenydfedprmirskaklegfs 101 Listeria innocua C...
5B0S_A     24 FEVIGAFNGGVAEYng--eVLLLLRVaekpvsedpeivlapvynaknkelelqsfrlddenydfedprmirskaklegfs 101 Listeria innocua C...
GAP08628   25 YPVNTVFNPGATLLpd-gsTLLLCRVedrt-------------------------------------------------- 53  Anaerolinea thermo...
OGO19402   44 WESKAAFNPGAIYAqg--kVHIVYRAigds-------------------------------------------------- 71  Chloroflexi bacter...
AHG93799   32 ARAAGAFNAGAAIDhrtgsVVLLVRVfesd-------------------------------------------------- 61  Gemmatimonadetes b...
KKQ76065    5 WEKDAVFNGCPIKDeg--nYHLLYRAleqdatvd---------------------------------------------g 37  Parcubacteria bact...
OGF25727   20 WQSLMVYNPGVIRKng--vYHLFYRAvgag-------------------------------------------------- 47  Candidatus Falkowb...
KKQ54084   30 WEAEKLYNSGAIFFdg--kYHLFYRAvgkgt------------------------------------------------- 58  Parcubacteria (Fal...
3WAS_A     66 IGMNATLNAGAIKWdg--kYLMLVRVegad-------------------------------------------------- 93  Bacteroides fragil...
5B0P_A     24 FEVIGAFNGGVAEYng--eVLLLLRVaekpvsedpeivlapvynaknkelelqsfrlddenydfedprmirskaklegfs 101 Listeria innocua C...
5B0S_A     24 FEVIGAFNGGVAEYng--eVLLLLRVaekpvsedpeivlapvynaknkelelqsfrlddenydfedprmirskaklegfs 101 Listeria innocua C...
GAP08628   25 YPVNTVFNPGATLLpd-gsTLLLCRVedrt-------------------------------------------------- 53  Anaerolinea thermo...
OGO19402   44 WESKAAFNPGAIYAqg--kVHIVYRAigds-------------------------------------------------- 71  Chloroflexi bacter...
AHG93799   32 ARAAGAFNAGAAIDhrtgsVVLLVRVfesd-------------------------------------------------- 61  Gemmatimonadetes b...
KKQ76065    5 WEKDAVFNGCPIKDeg--nYHLLYRAleqdatvd---------------------------------------------g 37  Parcubacteria bact...
OGF25727   20 WQSLMVYNPGVIRKng--vYHLFYRAvgag-------------------------------------------------- 47  Candidatus Falkowb...
KKQ54084   30 WEAEKLYNSGAIFFdg--kYHLFYRAvgkgt------------------------------------------------- 58  Parcubacteria (Fal...
Feature 1                                                                                  #  
1VKD_A     79 ---trpFLHFGRSKDGINWEIEpeeiqwvdv-----------------------------------ngepfqpsYAYDPR 120 Thermotoga maritim...
3WAS_A     94 ---rksFFAVAESPNGIDNFRFweypvtlp-------------------------------------edvvpatNVYDMR 133 Bacteroides fragil...
5B0P_A    102 yltslsYIRIARSKDGHHFTLDekpflyp--------------------------------------fneyqtfGIEDAR 143 Listeria innocua C...
5B0S_A    102 yltslsYIRIARSKDGHHFTLDekpflyp--------------------------------------fneyqtfGIEDAR 143 Listeria innocua C...
GAP08628   54 ---grsHLCVARSANGVDGWQIdpsptlppd----------------------------------penypeelwGIEDPR 96  Anaerolinea thermo...
OGO19402   72 ---nvsVLGYASSIDGFHIDERldkpiyvpresfegaglvypaesnpqvtyvsaeddeeeegegdyvsgggglgGCEDPR 148 Chloroflexi bacter...
AHG93799   62 --tersSLALAVSSDGETVDEIldrpvltr-------------------------------------empyeqwGVEDAR 102 Gemmatimonadetes b...
KKQ76065   38 qkidlsTIGYAKSGDGIHFSSRkqlikpe---------------------------------------eswekfGCEDPR 78  Parcubacteria bact...
OGF25727   48 ---wisKIGHAVSGDGKKFICDkkpllsp--------------------------------------emtieknGLEDPR 86  Candidatus Falkowb...
KKQ54084   59 --dwksAIGYAVSRDGENFQRFdtpllfg--------------------------------------etesekrGLEDPR 98  Parcubacteria (Fal...
3WAS_A     94 ---rksFFAVAESPNGIDNFRFweypvtlp-------------------------------------edvvpatNVYDMR 133 Bacteroides fragil...
5B0P_A    102 yltslsYIRIARSKDGHHFTLDekpflyp--------------------------------------fneyqtfGIEDAR 143 Listeria innocua C...
5B0S_A    102 yltslsYIRIARSKDGHHFTLDekpflyp--------------------------------------fneyqtfGIEDAR 143 Listeria innocua C...
GAP08628   54 ---grsHLCVARSANGVDGWQIdpsptlppd----------------------------------penypeelwGIEDPR 96  Anaerolinea thermo...
OGO19402   72 ---nvsVLGYASSIDGFHIDERldkpiyvpresfegaglvypaesnpqvtyvsaeddeeeegegdyvsgggglgGCEDPR 148 Chloroflexi bacter...
AHG93799   62 --tersSLALAVSSDGETVDEIldrpvltr-------------------------------------empyeqwGVEDAR 102 Gemmatimonadetes b...
KKQ76065   38 qkidlsTIGYAKSGDGIHFSSRkqlikpe---------------------------------------eswekfGCEDPR 78  Parcubacteria bact...
OGF25727   48 ---wisKIGHAVSGDGKKFICDkkpllsp--------------------------------------emtieknGLEDPR 86  Candidatus Falkowb...
KKQ54084   59 --dwksAIGYAVSRDGENFQRFdtpllfg--------------------------------------etesekrGLEDPR 98  Parcubacteria (Fal...
Feature 1                                                                                     
1VKD_A    121 VVKIe--dTYYITFCTdd------------hgPTIGVGXTKdfkTFVRLPnay--------------------------- 159 Thermotoga maritim...
3WAS_A    134 LTAHed-gWIYGIFCAerhddnapigdlssatATAGIARTKdlkNWERLPdlkt-------------------------- 186 Bacteroides fragil...
5B0P_A    144 VTQIg--dTYHVNFSAvse-----------fgVADALVTTKdfeNLEYQGnif--------------------------- 183 Listeria innocua C...
5B0S_A    144 VTQIg--dTYHVNFSAvse-----------fgVADALVTTKdfeNLEYQGnif--------------------------- 183 Listeria innocua C...
GAP08628   97 ITYLaelnRYAVVYTAysr-----------ggPGVSLALTEdfqHFERYGmim--------------------------- 138 Anaerolinea thermo...
OGO19402  149 LTKId--dRIFMTYVAfdgy--------spprVALTSIYLDdflAKNWQWkkpvli---------------------spp 197 Chloroflexi bacter...
AHG93799  103 ITFLadegRYAITYTGysp-----------dgPRVCLATTDdllAPERYVrhgpr------------------------l 147 Gemmatimonadetes b...
KKQ76065   79 VTKId--dKFLIFYTAistfp------pnsdsIKVAVAITRdfqKIEERHlvt--------------------------- 123 Parcubacteria bact...
OGF25727   87 IVVId--gLYYLTYTAydg-----------fsARLCLATSKdlkNWIRHGemipdwdfkrahgfiv--pwdsaqktpaaa 151 Candidatus Falkowb...
KKQ54084   99 ITKIg--dTFYMAYAAydg-----------vtPRLCVATSLdlkVWEKQCpvffdwnfkkaggvylewdeegelhekekf 165 Parcubacteria (Fal...
3WAS_A    134 LTAHed-gWIYGIFCAerhddnapigdlssatATAGIARTKdlkNWERLPdlkt-------------------------- 186 Bacteroides fragil...
5B0P_A    144 VTQIg--dTYHVNFSAvse-----------fgVADALVTTKdfeNLEYQGnif--------------------------- 183 Listeria innocua C...
5B0S_A    144 VTQIg--dTYHVNFSAvse-----------fgVADALVTTKdfeNLEYQGnif--------------------------- 183 Listeria innocua C...
GAP08628   97 ITYLaelnRYAVVYTAysr-----------ggPGVSLALTEdfqHFERYGmim--------------------------- 138 Anaerolinea thermo...
OGO19402  149 LTKId--dRIFMTYVAfdgy--------spprVALTSIYLDdflAKNWQWkkpvli---------------------spp 197 Chloroflexi bacter...
AHG93799  103 ITFLadegRYAITYTGysp-----------dgPRVCLATTDdllAPERYVrhgpr------------------------l 147 Gemmatimonadetes b...
KKQ76065   79 VTKId--dKFLIFYTAistfp------pnsdsIKVAVAITRdfqKIEERHlvt--------------------------- 123 Parcubacteria bact...
OGF25727   87 IVVId--gLYYLTYTAydg-----------fsARLCLATSKdlkNWIRHGemipdwdfkrahgfiv--pwdsaqktpaaa 151 Candidatus Falkowb...
KKQ54084   99 ITKIg--dTFYMAYAAydg-----------vtPRLCVATSLdlkVWEKQCpvffdwnfkkaggvylewdeegelhekekf 165 Parcubacteria (Fal...
Feature 1                                                                                     
1VKD_A    160 vpfNRNGVLFPRKINGKYVXLNrpsdng--htpfgdIFLSESPDx------iHWGNHr-fVLGRSSynww--enlkIGAG 228 Thermotoga maritim...
3WAS_A    187 ksqQRNVVLHPEFVDGKYALYTrpqdgfidtgsgggIGWALIDDit----haEVGEEk-iIDKRYYhtik---evkNGEG 258 Bacteroides fragil...
5B0P_A    184 apeNKDVLIFPEKINGKYYALHrpslks---ignldIWIASSPDl------rSFGDHr-hLLGIRPgeyd---sgrVGGG 250 Listeria innocua C...
5B0S_A    184 apeNKDVLIFPEKINGKYYALHrpslks---ignldIWIASSPDl------rSFGDHr-hLLGIRPgeyd---sgrVGGG 250 Listeria innocua C...
GAP08628  139 ppeDKDAALLPYRIGNKWALIHrpigy-----lgahMWISYSPDl------kHWGDHk-lMLEARRgaww--dankIGLS 204 Anaerolinea thermo...
OGO19402  198 gviDKNACILPEKIKSKYVIFHrif---------pdILIDFVDDldfd-gttRWLKGe-fKIRPRAaywd---srkVGAG 263 Chloroflexi bacter...
AHG93799  148 ageNKNCVVFPERIDGRYAILHrpm---------prAVLARADAle-----aEWPNDgptVLGPRPgtwr---sarVGAG 210 Gemmatimonadetes b...
KKQ76065  124 pfnAKAMALFPDKINGKYAAILtvdtd----kppakIAVAYFDKleqlwdsaYWEKWq-rSLDDNIlpslrtlddhVELG 198 Parcubacteria bact...
OGF25727  152 kywSKAGGIFPEKINNKFYMLFgd----------rhIWLANSDDg------lSWRPTykpFLKPRLnffd---sahIEMG 212 Candidatus Falkowb...
KKQ54084  166 sewSKSGGIFPEKVNGKYLMLFge----------yrIWFAESDDg------iHWIGDqspFLEPREgdyf--dnafVEMG 227 Parcubacteria (Fal...
3WAS_A    187 ksqQRNVVLHPEFVDGKYALYTrpqdgfidtgsgggIGWALIDDit----haEVGEEk-iIDKRYYhtik---evkNGEG 258 Bacteroides fragil...
5B0P_A    184 apeNKDVLIFPEKINGKYYALHrpslks---ignldIWIASSPDl------rSFGDHr-hLLGIRPgeyd---sgrVGGG 250 Listeria innocua C...
5B0S_A    184 apeNKDVLIFPEKINGKYYALHrpslks---ignldIWIASSPDl------rSFGDHr-hLLGIRPgeyd---sgrVGGG 250 Listeria innocua C...
GAP08628  139 ppeDKDAALLPYRIGNKWALIHrpigy-----lgahMWISYSPDl------kHWGDHk-lMLEARRgaww--dankIGLS 204 Anaerolinea thermo...
OGO19402  198 gviDKNACILPEKIKSKYVIFHrif---------pdILIDFVDDldfd-gttRWLKGe-fKIRPRAaywd---srkVGAG 263 Chloroflexi bacter...
AHG93799  148 ageNKNCVVFPERIDGRYAILHrpm---------prAVLARADAle-----aEWPNDgptVLGPRPgtwr---sarVGAG 210 Gemmatimonadetes b...
KKQ76065  124 pfnAKAMALFPDKINGKYAAILtvdtd----kppakIAVAYFDKleqlwdsaYWEKWq-rSLDDNIlpslrtlddhVELG 198 Parcubacteria bact...
OGF25727  152 kywSKAGGIFPEKINNKFYMLFgd----------rhIWLANSDDg------lSWRPTykpFLKPRLnffd---sahIEMG 212 Candidatus Falkowb...
KKQ54084  166 sewSKSGGIFPEKVNGKYLMLFge----------yrIWFAESDDg------iHWIGDqspFLEPREgdyf--dnafVEMG 227 Parcubacteria (Fal...
Feature 1                               #                                                     
1VKD_A    229 PYPIETseGWLLIYHgvtlt-cngyvYSFGAALLDldDPSKVLYRsryYLLTPEEEYetv----gfvPNVVFPCAAlcda 303 Thermotoga maritim...
3WAS_A    259 PHPIKTpqGWLHLAHgvrnc-aaglrYVLYMYMTSldDPTRLIASpagYFMAPVGEErig-----dvSNVLFSNGWiad- 331 Bacteroides fragil...
5B0P_A    251 CVPIKTeeGWLILYHgate----enrYVMGAALLDlnDPTIVLKRtktPILEPVADYekn----gffGDVVFACGAiqe- 321 Listeria innocua C...
5B0S_A    251 CVPIKTeeGWLILYHgate----enrYVMGAALLDlnDPTIVLKRtktPILEPVADYekn----gffGDVVFACGAiqe- 321 Listeria innocua C...
GAP08628  205 SPPIQTpqGWLVIYHgvrqt-aagalYRLGLALFDldNPARCLRRsdsWIFGPEEPYerh----gdvDNVVFPCGYtlap 279 Anaerolinea thermo...
OGO19402  264 APPIKTkdGWLLIYQaigeg--dpgrYKIGAMLLDlkDPTRVLARsgePIMEPEAWYene----gwkAGVIYPCGAvvi- 336 Chloroflexi bacter...
AHG93799  211 APPVRTrlGWLLPFHgatti-degnvYSMGWCVLDleRPERVRYVsdaPALTPEAPYeiepgpipqvDMANFRTGVrvvf 289 Gemmatimonadetes b...
KKQ76065  199 APPVKTadGWLIIYSyikdyftsdkiFSIEAALLDinNPLKLIGRspsPLLIPEIDYets----gliPDVVFPSGAlik- 273 Parcubacteria bact...
OGF25727  213 PPPLKTkkGWLVLYHgienk-kgriiYRLGFVLLDlkNPSKILYRtskPVFAPPAGHit------sgFINILPGGFkame 285 Candidatus Falkowb...
KKQ54084  228 PPPIRTekGWLVLYHginq----qhcYKIGFLLLDlvDPKKILYRsdkPIFEPEKDYem------sgIVDVLPGGLsalq 297 Parcubacteria (Fal...
3WAS_A    259 PHPIKTpqGWLHLAHgvrnc-aaglrYVLYMYMTSldDPTRLIASpagYFMAPVGEErig-----dvSNVLFSNGWiad- 331 Bacteroides fragil...
5B0P_A    251 CVPIKTeeGWLILYHgate----enrYVMGAALLDlnDPTIVLKRtktPILEPVADYekn----gffGDVVFACGAiqe- 321 Listeria innocua C...
5B0S_A    251 CVPIKTeeGWLILYHgate----enrYVMGAALLDlnDPTIVLKRtktPILEPVADYekn----gffGDVVFACGAiqe- 321 Listeria innocua C...
GAP08628  205 SPPIQTpqGWLVIYHgvrqt-aagalYRLGLALFDldNPARCLRRsdsWIFGPEEPYerh----gdvDNVVFPCGYtlap 279 Anaerolinea thermo...
OGO19402  264 APPIKTkdGWLLIYQaigeg--dpgrYKIGAMLLDlkDPTRVLARsgePIMEPEAWYene----gwkAGVIYPCGAvvi- 336 Chloroflexi bacter...
AHG93799  211 APPVRTrlGWLLPFHgatti-degnvYSMGWCVLDleRPERVRYVsdaPALTPEAPYeiepgpipqvDMANFRTGVrvvf 289 Gemmatimonadetes b...
KKQ76065  199 APPVKTadGWLIIYSyikdyftsdkiFSIEAALLDinNPLKLIGRspsPLLIPEIDYets----gliPDVVFPSGAlik- 273 Parcubacteria bact...
OGF25727  213 PPPLKTkkGWLVLYHgienk-kgriiYRLGFVLLDlkNPSKILYRtskPVFAPPAGHit------sgFINILPGGFkame 285 Candidatus Falkowb...
KKQ54084  228 PPPIRTekGWLVLYHginq----qhcYKIGFLLLDlvDPKKILYRsdkPIFEPEKDYem------sgIVDVLPGGLsalq 297 Parcubacteria (Fal...
Feature 1                       #        
1VKD_A    304 ------dtgRVAIYYGAADTHVALAFG 324 Thermotoga maritima MSB8
3WAS_A    332 ------ddgKVFIYYASSDTRMHVATS 352 Bacteroides fragilis NCTC 9343
5B0P_A    322 -------gdTLHMYYGVADTSMAGCDM 341 Listeria innocua Clip11262
5B0S_A    322 -------gdTLHMYYGVADTSMAGCDM 341 Listeria innocua Clip11262
GAP08628  280 ------dgdTLRLYYGAADSCIALATA 300 Anaerolinea thermolimosa
OGO19402  337 -------kdRLLVYYGGADRVTCVASV 356 Chloroflexi bacterium RBG_16_50_9
AHG93799  290 pqglvergaDYLVYYGAADVSVAGARV 316 Gemmatimonadetes bacterium KBS708
KKQ76065  274 -------ndELGVYYGASDNYCCLATC 293 Parcubacteria bacterium GW2011_GWC1_38_6
OGF25727  286 i----meqkNLKKFIKKTAQKRELPRI 308 Candidatus Falkowbacteria bacterium RIFOXYA2_FULL_47_19
KKQ54084  298 k----msdkELKNFLAEAEKKGIMPRV 320 Parcubacteria (Falkowbacteria) bacterium GW2011_GWF2_38_1205
3WAS_A    332 ------ddgKVFIYYASSDTRMHVATS 352 Bacteroides fragilis NCTC 9343
5B0P_A    322 -------gdTLHMYYGVADTSMAGCDM 341 Listeria innocua Clip11262
5B0S_A    322 -------gdTLHMYYGVADTSMAGCDM 341 Listeria innocua Clip11262
GAP08628  280 ------dgdTLRLYYGAADSCIALATA 300 Anaerolinea thermolimosa
OGO19402  337 -------kdRLLVYYGGADRVTCVASV 356 Chloroflexi bacterium RBG_16_50_9
AHG93799  290 pqglvergaDYLVYYGAADVSVAGARV 316 Gemmatimonadetes bacterium KBS708
KKQ76065  274 -------ndELGVYYGASDNYCCLATC 293 Parcubacteria bacterium GW2011_GWC1_38_6
OGF25727  286 i----meqkNLKKFIKKTAQKRELPRI 308 Candidatus Falkowbacteria bacterium RIFOXYA2_FULL_47_19
KKQ54084  298 k----msdkELKNFLAEAEKKGIMPRV 320 Parcubacteria (Falkowbacteria) bacterium GW2011_GWF2_38_1205

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