Conserved Protein Domain Family
SWIB_BAF60C

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cd17676: SWIB_BAF60C 
SWIB domain found in BRG1-associated factor 60C (BAF60C) and similar proteins
BAF60C, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (SMARCD3), or 60 kDa BRG-1/Brm-associated factor subunit C, is a core subunit of the SWI/SNF chromatin-remodeling complex that activates the transcription of fatty acid oxidation genes during fasting. It is involved in chromatin remodeling and hepatic lipid metabolism. It is also essential for cardiomyocyte differentiation at the early heart development. Moreover, BAF60C drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Furthermore, BAF60C epigenetically regulates epithelial-mesenchymal transition (EMT) by activating WNT signaling pathways.
Statistics
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PSSM-Id: 349495
Aligned: 6 rows
Threshold Bit Score: 157.841
Created: 6-Jul-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:The SWIB domain and the MDM2 domain share a common evolutionary origin and thus adopt similar structures, which suggests the SWIB domain may interact with a helical peptide through a cleft on the surface.
  • Comment:Based on the structural evidence that MDM2 domain binds p53 or other peptides.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #  ## ##  ##    #    ## #                #  ##            
Q6STE5       265 LDPRLARLLGlHTQSRSAIVQALWQYVKTNRLQDsHDKEYINGDkYFQQIFDCPRLKFsEIPQRLTALLLPPDP 338 human
KFO15165     159 LDPRLARLLGiHTQTRSAIIQALWQYIKTNKLQDsHDKEYINCDkYFQQIFDCPRLKFsEIPQRLTNLLLPPDP 232 Balearica pavonina gi...
XP_006006954  55 LDPRLARLLGiHTQTRSAIIQALWQYIKTNKLQDsHDKEYINCDkYFQQIFDCPRLKFsEIPQRLTNLLLPPDP 128 coelacanth
NP_001120778 258 LDPRLARLLGiHTQTRSSIIQALWQYVKTNKLQDsHDKEYINCDkYFQQIFDCPRLKFsEIPQRLTNLLLPPDP 331 zebrafish
XP_007909691 256 LDPRMARLLGiHTQTRSAIVQALWQYIKTNKLQDsHDKEYVSCDkYFQQIFDCPRLKFsEMPQRLTNLLLPPDP 329 elephant shark
OCT73632     250 LDPRLARLLGlHTQTRAVIIQALWQYIKSNKLQDcHDKEYITGDkYFQQIFDCPRVKFsEIPQRLTNLLLPPDP 323 African clawed frog

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