Conserved Protein Domain Family
GT4_AmsD-like
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cd03820: GT4_AmsD-like 
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins
This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Links
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Statistics
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PSSM-Id: 340847
Aligned: 42 rows
Threshold Bit Score: 274.115
Created: 15-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #                                                               
Q46634      3 KLLILIDGIsn---sGGTDRVASTLSSLLsn--hNYDVTLYSLNSGe----PYYPVDNKVSIRQPkss------------ 61   Erwinia amylovora
NP_810265   1 MNILFIDNLepnpllGGISRVISCLASSL-----KENYGFVVSHAA-----EKFDKHKQTELDIIlk------------- 57   Bacteroides theta...
BAE04001    3 SFTFFMHNIya---lGGTVKAVSELANTLad--kGHHIEIISVFRAqd--ePYFKINDNIKIKTLvdyrlkpqntkaimm 75   Staphylococcus ha...
CAP54438   21 RCCFLIEHIga---lGGTERAACQVMTGLaerggFEAIHLLEVFPVg---pAPFPFDPSIRRAALsarkis--------- 85   Gluconacetobacter...
CAA19236    2 KISFLINNIyg---iGGTNRTVINLAEALs---vQHDVEIVSVFRRan--aTKFEISPRITVRALvdlrpgssdrgaags 73   Streptomyces coel...
NP_765499   7 SFTFFMHNIya---mGGTVKSVTQLANTLae--kGHPVTIISVFRGad--sPYFELHSAIKVKVLvdyrlklkntraita 79   Staphylococcus ep...
CAB75373    2 KITFLLTWGde---mGGTEQAVYTQATHLa---pRHDIEVLSVFKTre--qPFFSVDERVSVRYLvdrtgkterpvresd 73   Streptomyces coel...
YP_808012   2 KVMIVLENIv----mDGVKRASTVLGNDLv---kHYDVSFYSLADAp----AYFELDAPLLIAPRptdpkllnf------ 64   Lactobacillus cas...
YP_099284   2 KIVFLCDSIfs---yGGVQKVLAVIATELs---kYNDVIILTHDKAeesdaTMYGLDRSAVKIIFmhrdrpaawe----- 70   Bacteroides fragi...
EDP69715    2 KVDFIISSIg----gGGAERVLALMVNSLak-npKNEISVIYFFEGk----GGYELDPNVKTTKLkqtky---------- 62   Flavobacteriales ...

Feature 1                                                                                     
Q46634     62 ----------------------mrLFKLFEFIRYAKn---------------------TRPDGVMIIsmg---klsVQAL 95   Erwinia amylovora
NP_810265  58 ----------------------ddQSYIPILRQFLIn---------------------KDIDIIVNMrptycvgiiNKAK 94   Bacteroides theta...
BAE04001   76 nrlnkytsllkpkeinqfepglnqFSKYVEHKMIKAik-------------------kVDTDVLVGTras---fniLISK 133  Staphylococcus ha...
CAP54438   86 -------------------vlgawPRLVHRLRAYVRm---------------------HAIDVLIVVesth-alyaIPAL 124  Gluconacetobacter...
CAA19236   74 de-----psavvprqeeffaqysrFTDERIIRDLRR----------------------TDADVVVGTrps---lnlFVAA 123  Streptomyces coel...
NP_765499  80 nrikkytpflntkvisqfepgksqFSSYVEKKMIKAir-------------------hTKTDVLVGTras----fnILIS 136  Staphylococcus ep...
CAB75373   74 ltaedcrhlaglpsdlispkweatFDALSDVEMQRAlr-------------------tIDTDVLITTsp-----alMSAV 129  Streptomyces coel...
YP_808012  65 ---------------fgsdpythyRDQINDLIMTIRd---------------------QHFQAVILPagl---ttsFAPL 105  Lactobacillus cas...
YP_099284  71 --------------ylpcktysflYKKVLPHKKIFSiiynhssfsytqqkrleehlnrTQADIIIGVh--------AFIS 128  Bacteroides fragi...
EDP69715   63 -------------------ipshtIRSIINLSRHYKnk-------------------nNRPDVIVSFvtl----tnLIAI 100  Flavobacteriales ...

Feature 1                                                                                     
Q46634     96 LLSKl--------FRVKSRLICCDHvsietlsaavr--------------------------------klkvfcyglaEK 135  Erwinia amylovora
NP_810265  95 ADLKc--------KYIIEYHSTPFYarkdkkfafkrllrydikqepfrysiklllfplwyhlsylrvsklwkrnyinaDK 166  Bacteroides theta...
BAE04001  134 YHSNd-------vITVGMEHMNLHAhpenyqqd-------------------------------------iltayrniDL 169  Staphylococcus ha...
CAP54438  125 AGTGv--------RCVVWEHFNFGVdlgrrprrw-----------------------------------grrvagrwaDD 161  Gluconacetobacter...
CAA19236  124 HTREg-------aLRVAQEHMTHLAippavrae-------------------------------------marvyprlDA 159  Streptomyces coel...
NP_765499 137 KYAKae------iVTIAMEHMNFDAhpdqyqke-------------------------------------iiaayrniNK 173  Staphylococcus ep...
CAB75373  130 ADLAps-----rvITIQQEHRPSQLrggtgepl--------------------------------------llrapaiDA 166  Streptomyces coel...
YP_808012 106 IKQAlp-----dvNLIGWMHNNYATymedyyvqmq---------------------------------aefegglqavDT 147  Lactobacillus cas...
YP_099284 129 IKLAiirkrleakKVIGWIHTSYEAlfdpqgaylprq------------------------------keqfryiipnlNS 178  Bacteroides fragi...
EDP69715  101 IVAKlf-----siKIIAQEHNSHLRfmqgrkritn---------------------------------ftkkyiykkaDI 142  Flavobacteriales ...

Feature 1                                                            ###                      
Q46634    136 VVVLTqhdk---nyltSAFSLKNVYVVGNISPFHHEnslnrfddvfarKQNRVLAVGRLTY--QKNFGRLLDIWKNVh-- 208  Erwinia amylovora
NP_810265 167 YILLSnnyiddfvnefNIIDASKLLAINNPLSYKEFlpis----rlqnKQKRVLIVSRLWN--YKRIDMSLEIWKLIee- 239  Bacteroides theta...
BAE04001  170 VTTLTqqdq----lnyEQQIDTPVYTIPNIINPVKHat---------kKENIIISAGRLEF--EKGFDILIESVRRIqnd 234  Staphylococcus ha...
CAP54438  162 VVTLTqrditmwrmgiGTGMRAHLTAISNAAPPVWRtay-------pvESRVVLAVGRLVP--QKGYDRLIEAWRLLard 232  Gluconacetobacter...
CAA19236  160 ITTVTeadag-sfmenTPIPGITVVGIPNSVPRPSVqps-------dcTRKIVVSAGRMHH--VKRYDLLIRAFGSLad- 228  Streptomyces coel...
NP_765499 174 ITTLTaadq----qkyQSQLKTPVYVIPNMVTEKRIaa---------pKKNRIISAGRLEY--EKGYDLLLESIRLIqed 238  Staphylococcus ep...
CAB75373  167 LVVLTertkq-wleesLGKAAPRLAAIPNAIPEGFRprs-------slTGKTIVMPRRLVP--DKQVDHAIQAFAKAlp- 235  Streptomyces coel...
YP_808012 148 LVTLTesd-----lnsYKRFNPNTVKIYNPLTLNPTgea-------nlDAHRIAFTGRIAIa-HKGIDFLLEAAASL--- 211  Lactobacillus cas...
YP_099284 179 VIVLTrhdr----ilyKSQLNIETITIHNPVTLEEThilp-----kerIQKRFLAIGRLSHq-TKGFDLLIEAFAQFrl- 247  Bacteroides fragi...
EDP69715  143 ITVLTsfd-----ieyYENYGSKVYVMPNPCSFKAIetn------sheREKIILAAGHLNRynHKGFDNLIELITPIvk- 210  Flavobacteriales ...

Feature 1                                                  #                      #           
Q46634    209 --KQGWKLLIVGDGEEKAELle--kiKKYHLEESAEIVSp--sKKISEYYRSSGVIAMTSRY-EGLPMVLIEAKNYALPA 281  Erwinia amylovora
NP_810265 240 -qVGDWELRIIGDGPEEEYLrr--lvCRYNLKRVVFVGN----TEPKEEYEKASLFISNSAI-DGWMITLTEAQQMGTVP 311  Bacteroides theta...
BAE04001  235 lkQLNFKVEIYGDGQERGHLqq--liDQHQLNDLITIYPa--tQQLNTKLSNSKITVVPSRN-EGFGMVLLEAMAQDNIV 309  Staphylococcus ha...
CAP54438  233 paLAAWRLAIVGDGPLRGVLer--qiADAELGERIELAPa--tVAIETYYARAALYCCASRF-EGFPMVLLEAAAAGVPA 307  Gluconacetobacter...
CAA19236  229 -eFPDWQLRIYGDGGEAGKLrt--lvTELGLSGRALLMGg--fSPIDSEWAKGSIAAVTSSA-ESFGMTLVEAMRCGLPV 302  Streptomyces coel...
NP_765499 239 lrQLNYDVHIYGSGSKKTSLvd--fiNQYHLNDLIKIYEp--tQELNNKLAQSKIVVVPSRN-EGFGMIILEAMVQDNIV 313  Staphylococcus ep...
CAB75373  236 -dHPGWRLRIFGDGPQMSRLrn--liQGLGLHDSVELLGp--sQHMTEEWARASLTILPSQDgEAFPLVLLEAFAAGVPA 310  Streptomyces coel...
YP_808012 212 --PDDWQIAIAGSGTDEDMKnfydliDYFHVADKLIYQGplkdQALRDHYRNASIFVSTSRW-EGMPLVIGEAMASGLPI 288  Lactobacillus cas...
YP_099284 248 -kHDGWILDIIGEGPEEPLLrn--liRKHRMENSIKIHPf--tQNIASYYSASDVFILSSRW-EGFPLVLCEAMSMGLPV 321  Bacteroides fragi...
EDP69715  211 -aYPDWKLKIAGAGDEGLKYlkk-laVDNEIEDKVIFTGf--iNNIAEVMNESSIFILSSRF-EGLPMVLLEAMSQGMAC 285  Flavobacteriales ...

Feature 1                                                                          
Q46634    282 IAFDCKTGPAEIIKD--DGYVVDYQsnELFTAQLNQliASEQLRKNFAqaawqNSADYGPELILKKWND 348  Erwinia amylovora
NP_810265 312 LVMDSYKAVYQIITNheDGIIIQNNnvDEFAIQLLTlmKNDVKREEMAkaaikNSKRFAVENIVAQWVE 380  Bacteroides thetaiotaomicron...
BAE04001  310 ISFKDTLGPASIINHnsNGYLANYGdaGSLAKYIDIamNHVDEASQMIneghvTLKQYTPNTVYEKFMT 378  Staphylococcus haemolyticus ...
CAP54438  308 VAFNCETGPSEIIIDgeSGVLVPQGdvAGLAGALRAlmTDPVRRARLSvgarkRAEVFALPIVLARWYA 376  Gluconacetobacter diazotroph...
CAA19236  303 VSTDCPVGPREILSDgeDGFLVPNGqvSGIAWGLRRlmADEVLRRDMGeaalrNAARYDPAAVADRYVR 371  Streptomyces coelicolor A3(2)
NP_765499 314 ISFEGNVGPDSIINNgdNGYLVNYEnvSELAKRIDLttQHYNELDHIIenskdTLKQFSPDHIYQLFMS 382  Staphylococcus epidermidis A...
CAB75373  311 VAYDIVTGPAEIIRHgeDGLLVPPNdvESLAEAISRlmGDEALLRSYGekaheGSTRFAADVIVKQWEE 379  Streptomyces coelicolor A3(2)
YP_808012 289 VAMENTGSREYLGNNd-YGLLTKAQdvPDFVDNLQKmmSQPALRHHYAhqsleRASHFSPETIVSQWMP 356  Lactobacillus casei ATCC 334
YP_099284 322 IASDLPVVKEILSDEq-DCLIFQNGcvASLAEKMDRm-VTLKDIHTMGkaafaKSRHFLVSDIIEQWKK 388  Bacteroides fragilis YCH46
EDP69715  286 ISYNCKTGPSDIIEDnvNGLLIEDQnmPQMQNGLRRliESEDLRNRLSnegikSLDKYHISEITKRYEA 354  Flavobacteriales bacterium A...

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