1MG4,2XRP


Conserved Protein Domain Family
DCX1
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cd16109: DCX1 
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Dublecortin-like domain 1
Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).
Links
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Statistics
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PSSM-Id: 340526
Aligned: 15 rows
Threshold Bit Score: 138.971
Created: 29-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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tubulin bindingkey conserved
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:tubulin binding site [polypeptide binding site]
Evidence:
  • Comment: DCX binds the corner of four tubulin dimers and stabilizes both lateral and longitudinal lattice contacts.
  • Comment:Mutations in N- and C- terminal of DCX domain cause severe neuronal migration disorders in humans.
  • Structure:2XRP; Homo sapiens doublecortin repeat in complex with mammalian tubulin, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ###     #       #       #                #                          #
1MG4_A        14 KAKKVRFYRNGDRYFKGIVYAISPDRfRSFEALLADLTRTLsdn-vnLPQGVRTIYTIDGlKKISSLDQLVEGESYVCGS 92  human
2XRP_I         6 KAKKVRFYRNGDRYFKGIVYAVSSDRfRSFDALLADLTRSLsdn-inLPQGVRYIYTIDGsRKIGSMDELEEGESYVCSS 84  human
CAC67459     209 KAKRLRFYRNGDQYFKGIQYALQSDRvKSMQPLMEDLMKTVicdstaLPHGIRHIFTIDGaQRITSVDQFEDGGGYVCSS 288 nematode
NP_001161528  55 KAKKVRFYRNGDRFYKGIVLAVSLERfRSFEALLADLTRTLndk-vsLPQGVRTIFTIDGgGKINSLDDLEEGQSYVCAS 133 Saccoglossus ko...
EFX77430      33 KARKVKFYRNGDRFFKGVTLAVSTEKyRTFDSLLSELNRLVgdr-vnLHQGVRIIFTTDG-SKINTIEELQDGESYVCAS 110 common water flea
EKC37923      64 RAMKVRFYRNGDRFFKGIVYAVSAERfRTFESLMAELTSSPvcdkniLPNGVRYIFTAENgHKIRTLDELEEGESYVCAS 143 Pacific oyster
ELT89101      55 KAKKVRFYRNGDRFFRGMIYAVSPERfRTFDALMAELTSSPlgdktvLPQGVRHIFSLDGsRKIVDIDHIRDGESYVCAS 134 Capitella teleta
XP_002125182  54 RAKKVRFYRNGDNFHTGLVYAVSTTRfRTFEAMLIDLTNRLadk-vhLPHGVRVVFSLDGaRKIETIQELEHGESYVCAS 132 vase tunicate
KFM59515      66 KAKKVRFFRNGDKFFKGLLYVLSVERiRSFDSLLEDLTRVLvdk-vnLPKGVRFIFTIDGkEKILSLEHLIEGSSYVCSS 144 Stegodyphus mim...
XP_013416369  60 RAKKVRFYRNGDRFFKGMIYAVSPERfRTFESLLAELTSSPlcdknvLPSGVRHVFSIDGsKKITHLDQLEEGENYVCAS 139 Lingula anatina

Feature 1              
1MG4_A        93 IEPFKK 98  human
2XRP_I        85 DNFFKK 90  human
CAC67459     289 TDAFKP 294 nematode
NP_001161528 134 TDVFKR 139 Saccoglossus kowalevskii
EFX77430     111 TDQFKK 116 common water flea
EKC37923     144 TDVFKH 149 Pacific oyster
ELT89101     135 TQAFKR 140 Capitella teleta
XP_002125182 133 SDMFKR 138 vase tunicate
KFM59515     145 TDHFIK 150 Stegodyphus mimosarum
XP_013416369 140 TDAFRR 145 Lingula anatina

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