1C1Y,1WFY


Conserved Protein Domain Family
RBD
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cd01760: RBD 
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Ras-binding domain (RBD), structurally similar to a beta-grasp ubiquitin-like fold
The RBD of the serine/threonine kinase Raf is structurally similar to the beta-grasp fold of ubiquitin, a common structure involved in protein-protein interactions. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. A Raf-like RBD is also present in Regulator of G protein Signaling (RGS12 and RGS14) members of GTPase activating proteins.
Links
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Statistics
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PSSM-Id: 340461
Aligned: 5 rows
Threshold Bit Score: 92.466
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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key conserved
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:key conserved lysines
Evidence:
  • Comment:some members of this family have 1 or 2 of 3 (K29/R, K33/R, K48/R Ub numbering) of the 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have roles other than chain linkage
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #   #                     #                    
1C1Y_B       2 NTIRVFLPn----kQRTVVNVRngmSLHDCLMKALKVRGlQPECCAVFRLlhehkgKKARLDWNTDAAslIGEELQVDF 76   human
1WFY_A      17 ITFQLELVgl---eRVVRISAKptkRLQEALQPILAKHGlSLDQVVLHRPg-----EKQPMDLENPVSsvASQTLVLDT 87   house mouse
O14924     962 KHCCIHLPd----gTSCVVAVKagfSIKDILSGLCERHGiNGAAADLFLVg-----GDKPLVLHQDSSilESRDLRLEK 1031 human
O14924    1033 TLFRLDLVpi---nRSVGLKAKptkPVTEVLRPVVARYGlDLSGLLVRLSg-----EKEPLDLGAPISslDGQRVVLEE 1103 human
O94827     131 ECFTLKFDlnvdieTEIVPAMKk-kSLGEVLLPVFERKGiALGKVDIYLDq-----SNTPLSLTFEAYrfGGHYLRVKA 203  human

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