cd04986: IgC_CH2_IgA (this model, PSSM-Id:319289 is obsolete and has been replaced by 409375)
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin
IgC_CH2: The second immunoglobulin constant domain (IgC) of alpha heavy chains. This domain is found on the Fc fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns.
Jiyao W et al.(2023). "The conserved domain database in 2023.",