Conserved Protein Domain Family
CSTF1_dimer

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pfam16699: CSTF1_dimer (this model, PSSM-Id:318830 is obsolete and has been replaced by 339801)
Cleavage stimulation factor subunit 1, dimerisation domain
This family is the dimerisation domain, at the N-terminal, of a family of cleavage stimulation factor subunit 1 proteins from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The cleavage stimulation factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognizes U and G/U-rich cis-acting RNA sequence elements and helps to stabilize the cleavage and polyadenylation specificity factor (CPSF) at the polyadenylation site as required for productive RNA cleavage.
Statistics
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PSSM-Id: 318830
View PSSM: pfam16699
Aligned: 27 rows
Threshold Bit Score: 75.2949
Threshold Setting Gi: 167535784
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 75010860    11 NLLKCREQLYRMMISQLFYDGYHSVAVELTNLVR---ADPPCPPSDRLMNIFKQANQIEQ 67
gi 390365594    6 MTIREKDQMYRLIISQLLHDGYHEVAQQLSKIVC---PVPDCPPSDRLQKVVQLGLRAEP 62
gi 260782963    8 DGIKDREQLYKLVIGQLYYDGYESVAASLAKVVR---LQGALTPSDRLLRLTKLALVTEE 64
gi 802663280    9 PDIKDRDSMYRLIIGQLYYDGHKQLALDLSNSIG---TKPPPPPSDKLFRLMSLVKQFAD 65
gi 1005943781  10 tTIKERDTLYKLMISQLFYDGYQSIAHQLSGAIQlnlNHLASPPSDRLAHLVGLGLKTEG 69
gi 198419251    2 DAIKKRERMYRSIIGQLQNDGYMAIAKSLTSQVK---PFNPCTSSDFLFKAYSIGLEQVE 58
gi 313227798    3 DPVKDKDKLYRLIIGQLQFDGYIQVSKNLAQQAR---PSQGATPSDQLMKIFQAGLQTIE 59
gi 17533535     3 PDIKDREYMYRLIIGQLFYDGHQQIAVNLANTLGc--SAPAPPPSDKLFRLVTIAKQFVE 60
gi 768956019    6 PTLKDRQHLYKLIISQLLYDGYISIANNLINEVK---PETVVSPSEQLMQLAKIGLENDD 62
gi 147223362    6 VGLKDRQQLYKLIISQLLYDGYISIANGLINEIK---PQSVCAPSEQLLHLIKLGMENDD 62
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