2YMB


Conserved Protein Domain Family
MIT_C
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pfam16565: MIT_C (this model, PSSM-Id:318714 is obsolete and has been replaced by 465180)
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Phospholipase D-like domain at C-terminus of MIT
MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.
Links
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Statistics
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PSSM-Id: 318714
Aligned: 64 rows
Threshold Bit Score: 161.898
Created: 1-Aug-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YMB_A        108 GFSYESLFREYLNEtVTEVWIEDPYIRHTHQLYNFLRFCEMLIKR---PCKVKTIHLLTSLDE----GiEqVQQSRGLQE 180 human
39_pfamImport   1 GISYENLFGDYLAG-ANSITLIDPYIRLPYQLRNFMEFAKLLSEKk-nKENELRLHLITNNNE----D-FiEGAREAFSQ 73 
12_pfamImport   1 GVSFDTLLVPYLRG-AGKITITDPYIRQFHQARNLMELIEGIANVk-dPADEVHIKLVTAENRdgdgD-KlRKQLEYLVK 77 
29_pfamImport   1 GISYETLLMPYLLG-ASEISIVDPYIRLAHQGRNLVDLLALLAASk-dPADEIAVTLVTKEVRg---E-YeQQHLLMLKD 74 
49_pfamImport   1 GVSYESLLLPYLRG-ATDIRIVDPYIRLPHQGRNLVDLLALVASVk-dPADEIVVKLVTKEDKg---D-FqQQHLLMLKD 74 
42_pfamImport   1 GVTYDKLFDQYLQG-ARKITVTDSYIRIFYQIRNFMEFLETIAKIk-pKDDEVKVHLITAEDE----F-KgPQQVENFMK 73 
Q72AH6        535 GLSFDTLLGPYLKG-ATTITVTDPYIRLFYQVRNFMEFLETVVKHk-aPDEEVSVHLVTTEDE----F-KgEQQKDNFEK 607 Desulfovibrio ...
2_pfamImport    1 GISFDGLFGAYLKG-ASKITVTDPYIRLFYQIRNFMEFLEAIVKNk-aEEDEVAVHLVTVRDE----F-KgDLQDESFEK 73 
Q2N5J8        543 GISYNKLFAPYLEG-ASRIVVTDPYIRYFYQIKNMMEFVEMVIQRk-aLEDQVAVHLVTGPDD----G-NvQKQRELLDS 615 Erythrobacter ...
14_pfamImport   1 GVSYEKLFGPYLEG-ARSIEIIDPYIRTFHQCRNLMEVLEVIITHfdyCVPEIHVHLLTCPDQ----Y-DpVKQDDYLCQ 74 

2YMB_A        181 IEESLRSHGVLLEVQY--SSSIHDREIRFNNGWMIKIGRGLDYFKK--PQSRFSLGYCDFDLRPCHETTVDIFH 250 human
39_pfamImport  74 ITYSLETIGIIFTYEF--DENIHDRSIKIDNGWKIVLGRGLDIWQK--TGGWYDINEYIQEKRLCKACEVTFIY 143
12_pfamImport  78 IKQGALAGGIHFDVAF--DGAIHDRSIVTDTGWKILLGRGLDIFQYv-TGDVFDLATKLQEYRQVKAFGVTYIR 148
29_pfamImport  75 IQDSAATVGIQFTVAW--DQTIHDRSIRTDHGWKLLLGRGLDIFQKg-SGNQFDLGSRRQEFRQVFAFGITYIN 145
49_pfamImport  75 IQDGGASVGIKFNVEW--DETIHDRSITTDNGWKILLGRGLDIFQKg-SGSQFDMGARRQEFRQVVAFGVTYIN 145
42_pfamImport  74 IQENCAIAGVRFSWEFdeNQILHARHIVTDHGWKILLDRGLDIFQHyeMNDSFSLSNRLQQYRSCKAFEITYLR 147
Q72AH6        608 MKEAACSVGVNFTWEFdgTGTIHARHIVTDHGWKISLDRGLDIFQHyeMNDAFTFANRLQQCRPCKAFEVTFIK 681 Desulfovibrio vulgar...
2_pfamImport   74 IQESARTVGIDFTWEFddSGTIHARHIVTDHGWKISLDRGLDIFQHyeMNEAFAFANRLQQFRSSKAFEVTFIR 147
Q2N5J8        616 ITEACTGTGVDFTWAFdsSGTGHSRDIITDTGWKIVLDRGLDIFQApmRRDGFTLGDRLQEHRMLKNFYVTYVR 689 Erythrobacter litora...
14_pfamImport  75 IADALHPFGLTLEWDFddTNTIHARHFVIDDKWDILLDRGLDIWQKfdSGNAFAIESRVQEMRMVKQFEITYMK 148
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