4JVH


Conserved Protein Domain Family
STAR_dimer

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pfam16544: STAR_dimer (this model, PSSM-Id:318695 is obsolete and has been replaced by 406848)
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Homodimerisation region of STAR domain protein
This family is the homodimerisation domain of quaking proteins. Quaking-dimer is a helix-turn-helix dimer with an additional helix in the turn region. Dimerisation is required for adequate RNA-binding. Quaking is a prototypical member of the STAR (signal transducer and activator of RNA) protein family, which plays key roles in post-transcriptional gene regulation by controlling mRNA translation, stability and splicing. STAR_dimer is the homodimerisation domain, Qua1 of the STAR domain of a series of proteins referred to as STAR/GSG, or Signal Transduction and Activation of RNA/GRP33, Sam68, GLD-1 family. These are conserved in higher eukaryotes and are RNA-binding transcriptional regulators. The STAR domain is a KH domain flanked by two homologous regions, Qua1 and Qua2. Qua1, this family, is the homodimerisation domain, and the KH plus Qua2 is the RNA-binding region.
Statistics
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PSSM-Id: 318695
View PSSM: pfam16544
Aligned: 19 rows
Threshold Bit Score: 47.2458
Threshold Setting Gi: 961759756
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JVH_A         5 KPKPTPDYLXQLXNDKKLXSSLPNfcgIFNHLERLLDEEISRVRKDXYN---DtlnGSTEKR 63  human
XP_011534562  10 KPKPTPDYLMQLMNDKKLMSSLPNfcgIFNHLERLLDEEISRVRKDMYNdtlN---GSTEKR 68  human
XP_011435248   8 DERSTPEYLAQLLKDKKQIQAFPN---VFVHLEKLLDEEINRVRLQLFH---H---KGNGRi 60  Pacific oyster
XP_002127447  93 KTKERVNYLQQLLKDKKQCQLYPT---IFVHVERLLDEEIVKVRSVLFQ---N---Gdkqpl 145 vase tunicate
CBY30806      53 QDKDRATYLQQLIKDQKTCLNYPN---VFHHVERLLADEIVKVRSVLFQ---N---Ntkple 105 Oikopleura dioica
XP_005462304   6 KPRPGPDYLMQLMNDKKLMSGLPNfcgIFQHLERLLDEEIGRVRKDMYT---DmlnGSEKsg 64  Nile tilapia
XP_014938729   1 ------------------mtHFSRilfCLTHLKFLLLTEISRVRKDMYN---DtlnGSTEKR 41  cheetah
XP_002411792   8 sTQSIADYLAQLLKDKKQLAAFPN---VFIHLERLLDEEISKVRSSLFQi------NGMKKE 60  black-legged tick
CCD81674      25 MHKATPDYLQELLKDKRQLQNFPN---IFLHLEFILEKEITRVRQKLFHl-----nESVKKT 78  Schistosoma mansoni
XP_009009335  33 tDRKSSEYLTQLLNDKKALLGLPV---VFQHLDKILDEEINKVRSHLFN-------VCSNKE 84  Helobdella robusta
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