1KKH


Conserved Protein Domain Family
ERG12

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COG1577: ERG12 (this model, PSSM-Id:31765 is obsolete and has been replaced by 224493)
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Mevalonate kinase [Lipid metabolism]
Statistics
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PSSM-Id: 31765
View PSSM: COG1577
Aligned: 25 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 7-Oct-2002
Updated: 7-Oct-2002
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KKH_A     6 MIIETPSKVILFGEHAVVY-GYRAISMAIDLTSTIEIKETQEDEIILNLNDLNKSlg-------lnLNEIKNINpnnf-- 75  Methanocaldococcus ...
15595033   2 LRIRKPAKILFLGEHSAVY-GFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNS------------------------- 55  Lyme disease spiroc...
15672388   8 MSIKVPGKLFFAGEYSVTKeGNLALITTIETNFEVRISATTGKSIFKTNVGLSDFef-------slSKIEFTKEnpwn-- 78  Lactococcus lactis ...
18313828   2 VKIFVPAAVKLFGEHAVVY-GKPAISAAINKGVYVECEKSDK--LSIETAGYPSAl---------rFYPGEGRVeavga- 68  Pyrobaculum aerophilum
15926268   1 --------------MAVPF-NAGKIKVLIEALESGNYSSIKS--DVYDGMLYDAP------------------------- 38  Staphylococcus aure...
15926270   2 IQVKAPGKLYIAGEYAVTEpGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNp---------vTFSRDEDSivisdp 72  Staphylococcus aure...
15900306   2 IAVKTCGKLYWAGEYAILEpGQLALIKDIPIYMRAEIAFSDSYRIYSDMFDFAVD------------LRPNPDY------ 63  Streptococcus pneum...
15674903   4 YCVQTGGKLYLTGEYAILTpGQKALIHFIPLMMTAEISPAAHIQLASDMFSHKAG------------MTPDASY------ 65  Streptococcus pyoge...
125407     5 FLTSAPGKVIIFGEHSAVY-NKPAVAASVSALRTYLLISESSAPDTIELDFPDISfnhkwsindfnAITEDQVNsqklak 83  baker's yeast
16799089   2 ATGIGTAKMILCGEHAVVY-GEPAISVPFTQAIVTTNVETST-KTKFSSAFFTGD------------LENMPDFl----- 62  Listeria innocua
1KKH_A    76 ---gdfKYCLCAIKNTLDYLNi---------------------EPKTGFKINISSKIPI----SCGLGSSASITIGTIKA 127 Methanocaldococcus ...
15595033  56 -------LISFIVSNYSKVNP---------------------------IEFDIISEIPI----GVGLGSSASLSLCFAEY 97  Lyme disease spiroc...
15672388  79 ---falTALKNTLSAADSFEKksvs---------------kilSSSPEISLEIVSDLGFge-nKKGYGSSASVVCGLVNA 139 Lactococcus lactis ...
18313828  69 --erffAYINAALRLAEEKWG------------------------GLAARFYIKSELPP----GAGAATSAAVSIGLLKA 118 Pyrobaculum aerophilum
15926268  39 ------DHLKSLVNRFVELNN-----------------------ITEPLAVTIQTNLPP----SRGLGSSAAVAVAFVRA 85  Staphylococcus aure...
15926270  73 haakqlNYVVTAIEIFEQYAKsc-------------------dIAMKHFHLTIDSNLDDsnghKYGLGSSAAVLVSVIKV 133 Staphylococcus aure...
15900306  64 ------SLIQETIALMGDFLAvr-------------------gQNLRPFSLEICGKMEReg-kKFGLGSSGSVVVLVVKA 117 Streptococcus pneum...
15674903  66 ------ALIQATVKTFADYLGqs-------------------iDQLEPFSLIITGKMERdg-kKFGIGSSGSVTLLTLKA 119 Streptococcus pyoge...
125407    84 aqqatdGLSQELVSLLDPLLAqlsesfhyhaafcflymfvclcPHAKNIKFSLKSTLPI----GAGLGSSASISVSLALA 159 baker's yeast
16799089  63 -----aGIKALVVDVLNEIGN------------------------GENVSIHVTSGVPI----GRGLGSSAAVATSIARG 109 Listeria innocua
1KKH_A   128 VSGFYNKELKDDEIAKLGYMVEKEIQ----------GKASITDTSTITYKGILEIKNNk------------------FRK 179 Methanocaldococcus ...
15595033  98 ITSHF--EYKDCNKILLANQIENIFH----------GKSSGMDIRLIDLNGTFYLEKKe------------------NVL 147 Lyme disease spiroc...
15672388 140 VNQFFDFQLSLEKRFEIAAKTHFEVQ----------GSGSMGDIAAIMYGGSVFYQNH-------------------KRV 190 Lactococcus lactis ...
18313828 119 YALCAGGDVEGIELAKMGHRVELEVQ----------GIASPMDSTTVTLGGVLKIKTNp------------------FSV 170 Pyrobaculum aerophilum
15926268  86 SYDFLGKSLTKEELIEKANWAEQIAH----------GKPSGIDTQTIVSGKPVWFQKG-------------------HAE 136 Staphylococcus aure...
15926270 134 LNEFYDMKLSNLYIYKLAVIANMKLQ----------SLSSCGDIAVSVYSGWLAYSTFdhewvkhqiedttveevliKNW 203 Staphylococcus aure...
15900306 118 LLALYDVSVDQELLFKLTSAVLLKRG----------DNGSMGDLACIVAEDLVLYQS--------------------FDR 167 Streptococcus pneum...
15674903 120 LSAYYQITLTPELLFKLAAYTLLKQG----------DNGSMGDIACIAYQTLVAYTS--------------------FDR 169 Streptococcus pyoge...
125407   160 MAYLGGLIGSNDLEKLSENDKHIVNQwafigekcihGTPSGIDNAVATYGNALLFEKDsh----------------nGTI 223 baker's yeast
16799089 110 LYKYFNQELDSKKLLAIINAAEKIAH----------GNASGVDAITVVSEKPVWYERD-------------------RKL 160 Listeria innocua
1KKH_A   180 IKGEFEEFLkn-ckFLIVYAEKRKKKTA-------------ELVNEVAK-----IENKDEIFKEID-KVIDEALKIKNKE 239 Methanocaldococcus ...
15595033 148 HSKKIKDSGf----YFLIGAIKRDLTTK-------------EIVVNLKKdl-lsNAYLFVFIEKLG-LAVSNSYASFQNK 208 Lyme disease spiroc...
15672388 191 IPLEIPWAT-------YVVQTGKAAKTS---------------EKIKIKl-------sDEFYQASN-ELVIELATAIDIQ 240 Lactococcus lactis ...
18313828 171 DKLNANLPP------FYIAFLPRFETTG-------------EIVRGVKAll-erRRSAAFVIEAIG-RVVEEAEQCLLNR 229 Pyrobaculum aerophilum
15926268 137 TLKTLSLDG-----YMVVIDTGVKGSTR-------------QAVEDVHKlc--eDPQYMSHVKHIG-KLVLRASDVIEHH 195 Staphylococcus aure...
15926270 204 PGLHIEPLQapenmEVLIGWTGSPASSP-------------HFVSEVKRlk-sdPSFYGDFLEDSH-RCVEKLIHAFKTN 268 Staphylococcus aure...
15900306 168 QKVAAWLEEen-laTVLERDWGFSISQVkptlecdflvgwtKEVAVSSHmvqqiKQNINQNFLTSSkETVTSLVEALEQG 246 Streptococcus pneum...
15674903 170 EQVSNWLQTmp-lkKLLVKDWGYHIQVIqpalpcdflvgwtKIPAISRQmiqqvTASITPAFLRTSyQLTQSAMVALQEG 248 Streptococcus pyoge...
125407   224 NTNNFKFLDdfpaiPMILTYTRIPRSTKd------------LVARVRVLvtekfPEVMKPILDAMGeCALQGLEIMTKLS 291 baker's yeast
16799089 161 EIMHFPKKIt-----FVVADTGVPSETR-------------DAVKDVQIlykenQAEIGKIIHQLG-DISREIKLHLEGD 221 Listeria innocua
1KKH_A   240 D------------------FGKLMTKNHELLKKLN---ISTPKLDRIVDIGNRFGFG-AKLTGAGGGGCVIILVN----E 293 Methanocaldococcus ...
15595033 209 Dvy---------------sLANEMNIAQCCLKRLG---LSNDTLDWLISEGIKLGALsGKLSGAGKGGAFIFLFEslikA 270 Lyme disease spiroc...
15672388 241 Dfa---------------lFKEKLSENQLLLLENIpegYMTKELAIALNLLNSYPEFaAKISGAGFGENIILFAQn---T 302 Lactococcus lactis ...
18313828 230 Dle---------------cVGELMGINNWLLGALG---VVDERAINLLNAAR-PFIYgGKISGAGRGGAVILLPRs---E 287 Pyrobaculum aerophilum
15926268 196 Nfe---------------aLADIFNECHADLKALT---VSHDKIEQLMKIGKENGAIaGKLTGAGRGGSMLLLAKd---L 254 Staphylococcus aure...
15926270 269 Nikgv-----------qkmVRQNRTIIQRMDKEATv-dIETEKLKYLCDIAEKYHGA-SKTSGAGGGDCGITIIN----K 331 Staphylococcus aure...
15900306 247 Kse---------------kIIDQVEVASKLLEGLSt-dIYTPLLRQLKEASQDLQTV-AKSSGAGGGDCGIALSFd---A 306 Streptococcus pneum...
15674903 249 Hke---------------eLKKSLAGASHLLKELHp-aIYHPKLVTLVAACQKQDAV-AKSSGSGGGDCGIALAFn---Q 308 Streptococcus pyoge...
125407   292 KckgtddeavetnnelyeqLLELIRINHGLLVSIG---VSHPGLELIKNLSDDLRIGsTKLTGAGGGGCSLTLLRrditQ 368 baker's yeast
16799089 222 Adt--------------vkIGAAMNKAQSYLETLT---VSDSSLEKLIKVARSNGADgAKLTGGGRGGCIIAVAKn---Q 281 Listeria innocua
1KKH_A   294 E--K------------EKELLKELNKEDVRIFN----CRMMN 317 Methanocaldococcus jannaschii
15595033 271 NivQ------------KELNNMLKDSKIDLLLK----LKVIE 296 Lyme disease spirochete
15672388 303 QaiA-------------EVQNKLSEYGINLEKF----KVAQK 327 Lactococcus lactis subsp. lactis
18313828 288 DalE------------RVLSASGYVYHKVTIYE----GGVTV 313 Pyrobaculum aerophilum
15926268 255 Pt-A------------KNIVKAVEKAGAAHTWI----ENLGG 279 Staphylococcus aureus subsp. aureus N315
15926270 332 DvdK------------EKIYDEWTKHGIKPLKF-----NIYH 356 Staphylococcus aureus subsp. aureus N315
15900306 307 Qs-T------------KTLKNRWADLGIELLYQ----ERIGH 331 Streptococcus pneumoniae TIGR4
15674903 309 Da-R------------DTLISKWQEADIALLYQ----ERWGE 333 Streptococcus pyogenes M1 GAS
125407   369 EqiDsfkkklqddfsyETFETDLGGTGCCLLSAknlnKDLKI 410 baker's yeast
16799089 282 Ei-A------------KQITKALHNAGAAQEWIftigEGSYE 310 Listeria innocua
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