Conserved Protein Domain Family
ToxN_toxin

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pfam13958: ToxN_toxin 
Toxin ToxN, type III toxin-antitoxin system
ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex.
Statistics
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PSSM-Id: 316475
View PSSM: pfam13958
Aligned: 35 rows
Threshold Bit Score: 106.895
Threshold Setting Gi: 524299393
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam13958 is the only member of the superfamily cl16499
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490742328  10 FVNVDMDYLKHLHN-ACSEVFYK----PN-D-Y-DNKPYLGVLMTNNATKYVLPLTSAKE-------K--------HKTW 66
gi 524309989   3 WYVVDKKYINYLTQ-FDSRVGYV----EY-G-E-RLKLHVGILLTIGDFHYYVPISSAKP-------K--------HQKM 59
gi 524707957   6 WYIVNKKYVKYLKS-FDNKIENI----DY-Q-N-NLKPFIGIVLMINNFNYYVPVSSPKE-------K--------HYKM 62
gi 524005267   3 WINVNEKYLDYLRA-FEGRIPRT----DY-GsD-KYKPFFGILFETEDFYYITQVSHAQP-------R--------HQKM 60
gi 524299948   7 WYVVDKEYVSYLKE-FDNKVENI----DY-S-N-RFKPYLGIIITINEINYYVPISSVKE-------K--------HYKM 63
gi 524380856   6 LYKIDINYIKYLYS-FDNRVQYNpnreDE-Y-S-AKRPYLGIVLKIDKYDYFVPLEHPRH-------S--------HQTM 66
gi 524531996   6 WKIINKDYLDYLREnYESRIPRT----DY-G-NdKLKPFFGELMRVGDLAYVTQVSSAKP-------R--------HNKI 64
gi 524150188   3 LYEIDSQYMEYLYK-ADSKVLIH----NS-G-N-HQRKFIAIKVLINGYKYFVPLSSPDK-------RdyfndqdgHKKV 67
gi 503056968  37 IYTVNTDYIEFLRS-VDSRVLENe---KN-F-G-NLRKYVGVLFKINNYDYFVPLSSPKPsdyvymdG--------FKTI 101
gi 524480746   3 WLVVTEDYLKHLRK-KDKRIPFS----EYgE-K-KYKPFFGILFETEDFYYITQISHAQK-------R--------HKNM 60
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490742328  67 KDAy-PDRFLVfaiedkdsvsqnaicvatdddtkV--K----HILSAVDIKKMIPVTDDVISFVDFNI----------A- 128
gi 524309989  60 SNS--LDFHKLq---------------------dEstG----YLYAVLNINNMIPVPDNCLTQLKYNQ----------Ve 102
gi 524707957  63 KDG--IDFIKIk---------------------kE--D----RILGVLNLNNMIPILNQYVNVLKYNE----------Ie 103
gi 524005267  61 KKQ--PDFFKIydp------------------qvL--S----RLIAVVNLNYMFPIPKNEVTPFVKKDigtyrtfkseE- 113
gi 524299948  64 NED--IDFIKIs---------------------eN--D----RILGVLNLNNMIPIDNDSVKNLKYSE----------Ie 104
gi 524380856  67 KNN--IFIFKIh-----------------------------nGKYGILGFNNMIPVKKEQLIKFDIDK----------E- 104
gi 524531996  65 KAN--IDFQKIi---------------------hN--D----VLIAVVNLNYMFPVPVSEMTDLEYGK----------I- 104
gi 524150188  68 QFTrvPTIKRIf---------------------nG--NptveSYLGKLLFNNMIPVPEGCYHEFNIFL----------E- 113
gi 503056968 102 RHSv-VPIYRIiet-----------------sedK--I----NFLGKLKFSSMIPAPPSQLTLLDITS----------L- 146
gi 524480746  61 KNG--KDFKKIyn-------------------pkD--N----RLLAVINLNYMFPIPKSLKNVLKYKN----------Id 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490742328 129 ---------E----------GDpdevtKYKDLLNKEYVFCV--KKVDDILLK-ASRIYDKQI--S---Sg-KVQMFACDF 180
gi 524309989 103 sfrsfsnekE----------KT-----DYVYLLQKEKALID--NVQDTLQNK-ALKLYQKCI--Ak-pDs-SLAARCCNF 160
gi 524707957 104 kyrlfktdrE----------KN-----MYIALLNLELKIIN--SKYEEINRN-AIKLYKEKI--Kn-pNs-KVSRRCCNF 161
gi 524005267 114 ---------E----------KS-----KYIDLLDSEMKMIN----TMNLSDA-AKDLYEKKY--Af-pDs-RVSQRCLDY 160
gi 524299948 105 kyrnfktnkE----------KS-----LYISLLNMELELIN--SRIEKIKAN-AFKLYNEKT--Nr-pNs-KISKRCCDF 162
gi 524380856 105 --------------------NA-----GYKQILISQYHFCN--KHNKEIEEK-ANETYNRSVk-----Nh-FMKKICCDF 150
gi 524531996 105 ---------EeyvdfkndtaKS-----KYIDLLKREMKYIK----ELPLENN-ARSLYALKY--Dk-pEh-VISKRCFDF 161
gi 524150188 114 ---------K----------DL-----KYKGLLIDQVQVLRsfKNQEDILRR-AQIVYKLKK--Rk-sSynYIKLATVDF 165
gi 503056968 147 --------------------TE-----DYKTLIFNQIRHIR--KKLTVLQNRhAKVIYNQKK--AnyaNi-NYLNDTVDF 196
gi 524480746 104 tyrkfdtdkE----------KS-----KYINLLKTEKKVLN----QMNLEKS-AKLVYENKYltEk-qDi-ALADRCIDF 161

                 ....*..
gi 490742328 181 AKLESAL 187
gi 524309989 161 KMLEEKC 167
gi 524707957 162 KFLETKL 168
gi 524005267 161 KVLEEYA 167
gi 524299948 163 KVLEEKC 169
gi 524380856 151 RLLEEKS 157
gi 524531996 162 KTLEnga 168
gi 524150188 166 ELLERNC 172
gi 503056968 197 KKLEQAM 203
gi 524480746 162 KFMEKla 168
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