Conserved Protein Domain Family
KBP_C

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pfam12309: KBP_C 
KIF-1 binding protein C terminal
This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 365 and 621 amino acids in length. There is a conserved LLP sequence motif. KBP is a binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a type of kinesin interacting protein.
Statistics
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PSSM-Id: 315070
View PSSM: pfam12309
Aligned: 31 rows
Threshold Bit Score: 257.566
Threshold Setting Gi: 159115181
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam12309 is a member of the superfamily cl18610.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   223 VDWALNAATLSQFYFPKNHLSQARHLLAASTFMLNR--YETEV------------------------------------- 263
gi 159115181  431 QDFIINCLTLQKYYTTNNIFRPSFTLIDVAEEVLFE--YGPKE------------------------------------- 471
gi 1005949437 234 LEWCINTATLSQYFAGIDKFGISSHLLRVAKAMMDS-------------------------------------------- 269
gi 348509470  257 MEWALNAATLSQYYITKGRYMEGRHCLSAATVISDL--AGEVP------------------------------------- 297
gi 47218717   263 LEWALNAATLSQYYVSKA-------------------------------------------------------------- 280
gi 573885293  252 LEWAINAATLSQYYITKSRYMEGRHCLAAAVVVAGL--AGEVP------------------------------------- 292
gi 255072579  232 EEWAQNAAQLAGFYAARACWATARHCAAAAEKVFADanPGWKS------------------------------------- 274
gi 298705397  358 GEWSRNACFLADYYSGLGRFTGAGRCLLAAQAVLQPegSAAAVptggkdnaslpppppargkdegeekgedggnaksggd 437
gi 674577423  272 KDWANNTAALSEYYVETEEFGKALECLMTARTVVC--------------------------------------------- 306
gi 340384150  227 IEWSLNAATISQYYINVANYPQARHCLAAASVVLRS--YSDEL------------------------------------- 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   264 ---------VEKITNPAER------------AEKE--------------------ETLRYRM--------------ADVG 288
gi 159115181  472 ---------RAQYVKDLPAnenmpeddvaylQFRArqkvesvavirsilsldtarEVLAQIR--------------TERA 528
gi 1005949437 270 ---------KLPPKNDDD-------------------------------------EDLKKGR--------------ADFQ 289
gi 348509470  298 ---------SEAAAQENETe-----------SERR--------------------EHLRQKR--------------AEIA 323
gi 47218717   281 ----------------GEAa-----------SEQR--------------------EKHRMQS--------------AHIS 299
gi 573885293  293 ---------SEAAAQENEAe-----------GEKR--------------------EQLRQKR--------------AEIA 318
gi 255072579  275 ---------SEVDTSSSEVegsiptgsghgvGALD--------------------DDALNVG--------------ANVH 311
gi 298705397  438 sggatraggGGRETEKVSTanerkreeeegtEEER--------------------ERRREQR--------------ADVD 483
gi 674577423  307 -------------------------------------------------------ESFQNGDssglghnlngtklwADIS 331
gi 340384150  268 ---------GGKGEEMK--------------------------------------EKLEQSE--------------ADVS 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   289 RCWAkyglHILCASKERl---SADDEPNEHGEIAAPltp-----------------------vkKMDRFVGLD------- 335
gi 159115181  529 RLYS----QILSNSYQRrellLEARREQMKIQYTSSedlsnddkelahkqikavcqisqdecvsSVRELYDLLlapdlea 604
gi 1005949437 290 RIMVkyylMLLDCSSRQ------HTSEESEKTNGQKplqeqek------------------------------------- 326
gi 348509470  324 RCWIkyclNLLQDAKKQ----LEDNIGELDTDRQEElkrarrreeeeeekgrksallfgsedtfDS-------------- 385
gi 47218717   300 RCWIkyclNLLEDAKKL----LEDNAGELDTDHQDElkrarrlgeeeeeksrksallfgsedtfDS-------------- 361
gi 573885293  319 RCWIkyclNLLQDAKKL----LEDNIGELDVERQAElkarrrqedeeeekglksailfgsrdifDS-------------- 380
gi 255072579  312 LAWAklhlRRLTAATEL----FATRGATETGAGGEAkraastgddnali------------------------------- 356
gi 298705397  484 RHMAklyiTVLQAKHLE-----LGRGGGAGGEFCKVrtreeeeeeegl-------------------------------- 526
gi 674577423  332 WLTSeyslGLLEGGSKVvlgsRFTIDPELVDTSPSYgslfnqdttka--------------------------------- 378
gi 340384150  287 RCWIkyaiSLLTHS-------CTESGERGGGGGTREkvaivh-------------------------------------- 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   336 ---------------------LAAYE-GQVTDEFCLT----------FDD--AKLVMLNSLSWLNKAKEYYTKETEASQY 381
gi 159115181  605 tleaaakrqlrklglqtkgdvDPESEtDEKSGEKVTTpklq---nlfLAEplVRTLFYDSYRQFIAASRYFILDGFVTDH 681
gi 1005949437 327 ---------------veeyrlLEEDElNRMSCSPIIDklve---fgnFDQ--AKAIFVEAQKLLNLAKEYYTLNEHASDY 386
gi 348509470  386 ---------------------IASIE-EKVMCLFPLD----------FTE--ARSVFLVGQNHVTQAKDYFQMDGYVTDH 431
gi 47218717   362 ---------------------IASLE-EKVPCLFPLD----------FSE--ARAVFLVGQSHVKKAKEYFQMEGHVTDH 407
gi 573885293  381 ---------------------ILALE-EKVSCAYPLD----------FEE--ARAIFLVGQNYVTEAKEYFQMDGHVTDH 426
gi 255072579  357 ---------vsfptlrlgdggATSATeAAKTVGIVSQgpgegwvprdLAT--ARAVFNQAARRFRAALARYKLDGFVTEH 425
gi 298705397  527 ----------vagfaslgigeLPMCDpAGVPGD--------------FES--VRDVFKRAKSHTERALRHYVLDGFVTAH 580
gi 674577423  379 -----------lqeaygepiqDTGLT-TMISELSIMPk--------aYPA--AARLFRWTCRSLSEALLYYRLDERCTEA 436
gi 340384150  322 ---------------rfepleLADVE-GQVSCDVVEN----------YQD--ASKVFLFAEAQIKSAQKFYNLEDHATDF 373
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   382 AKILQDIASLYKHLAFFEE------------------DDGNQCKLFKRGADQLEEIVEILNATYYQTICREAWYELGLTY 443
gi 159115181  682 CQILLDISTLHQIYAYYEEarldfltnsatseeaekvSYTPLIKLHTRRCTTLEKVIPELSLDHYSKLIASLQVEVAEAR 761
gi 1005949437 387 VDCIQDHSKLYRHLSSFDF------------------DVDRKCKMYKRRVDMLEEILKEINPKHFMAQCRQIWFELGEAY 448
gi 348509470  432 IEILQDHSALFRSLAFFEE------------------DLERRCKMHKRRVDMLEPICNDLNAQYYLMIRRQLMFELAETY 493
gi 47218717   408 VEILQDHSALFRTLAFFEE------------------DLEARCKMHKRRIDMLEPVCNELNAQYYLMIRRQMMFELAETY 469
gi 573885293  427 IEVVQDHSALFKALSFFEE------------------DYERRCKMHKRRIDMLEPICKDLNAQYYLLICRQLQFELAETY 488
gi 255072579  426 CDVVLDVARLHKHLAFFEEs-----------------NPRRYNSLQRRRAERCERVAAELSRDKYPGLYKTLWFEYAEAH 488
gi 298705397  581 VALHQGLSRAYLYLSGFER------------------DAKRRQAMCTRRAQALEPLLDALARKAYARLHKELSFELGEIY 642
gi 674577423  437 IKLIRAHASAYGYLATFEA------------------DLPRKCCMQKRRVDLLEDLLAQLNPRFYMLSCRTIMSECAEAL 498
gi 340384150  374 VSISQDHSSLYKVLSFFES------------------DLSLKCRMHKRRVDILSSLLSCLNPQYYLVLNRQLMFELGDTL 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   444 SNMLNVK---------LSQLDEMQakDRPTPHAL------------NKINHLSEKSIRNFKKFIESYk---iELDTLELP 499
gi 159115181  762 TAIYHIVsrdiacnpyLKRLTEDMeyAAQLQLKQidplpdkdsvliSTVAAHCSRAIEAWRAVCKTYe---aDSRARLLQ 838
gi 1005949437 449 NEMYEMK---------VSKEKDQVttSA------------------KKLNSLLKKSTEHFVAFIDSFr----ENKNEPIP 497
gi 348509470  494 NEMMDLK---------LALANRQAdtQSLDNHTI------------KKFNHLCSASAKYFQMFLDSLc-----SPEGKFP 547
gi 47218717   470 DEMMNLK---------MIRANTQAdtQSLDKHSI------------KKINHLCSSAVKYFQMFLDSLr-----SLDGKFP 523
gi 573885293  489 YEMMDLK---------LALADKQ---DELDAHTV------------KKFNHLCAASIKYYKMFLDSIr-----TADGKFP 539
gi 255072579  489 RAILEGK---------IRRGRPP-----------------------LSLGDAARCATRGYTAYVDTFed--qVGSDRLNP 534
gi 298705397  643 QDLADIK---------TLRAEEKLksGGTRAPTAlas-------dlRGANKLLKSAIGFFSHFVAMYhegdpSGGSAESP 706
gi 674577423  499 TALRDLN---------EEKMKRTTirASPTSSLSstnivaelsklaKKVNGLGLRALEMYKRLLDSFl----TPANQREP 565
gi 340384150  436 NDMANNK---------IILASEEG--SSPSQHQI------------QKINRLLNDAIKHYGEFFSSF---------ETQP 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74781347   500 ET------IDADEMQPIL---------YAFFHIGRLYYR-IITPDKRLKLQNTENSLFYYSRFVECCQ--DERM------ 555
gi 159115181  839 EYhfkrkeFSKDEIMKFLtfddrdsmqTCIFETAKLLSQ-LPTCDPVIKHGLLADSLRCFEQVQKLWLd-NENL------ 910
gi 1005949437 498 PK------VPDEMVKPLI---------IAYFGAGRNYTK-ILTADKKDVISNWNKCEEFYSQAVKYIDn-NPDQ------ 554
gi 348509470  548 ER------LEEEVLRPAL---------VARFRVARLHSR-LISTSPTVQLDNLNKSLENYKYVVQYCEa-NPEA------ 604
gi 47218717   524 EK------LEEDVLRPAL---------VARFRMARLYSK-LICSLPSAQLENLNESLDNYMWVTRYCEd-HPEA------ 580
gi 573885293  540 EK------LEDDVLRPAL---------VAKFRVARLYGR-IICPDGATQLENLDKSLECYRFVVDYCEq-DTEA------ 596
gi 255072579  535 RRi-----IDSDEEKTYV---------TARFIRARTASK--QHGQFGSEADALGVALIDYEFVPAYVKa----------- 587
gi 298705397  707 SQpa--kgMEPDEAVGYL---------QARFMRARLNGK-LRPLTSEKELHALRVSCGEFAWLSEHARghLKSVretagd 774
gi 674577423  566 DL------YEEEWLPHVL---------MAHFYSARLHSKtIIAGAPRNRVGELHLAMKAYEKMVEIADkhARSG------ 624
gi 340384150  484 EA---------EYLHSFL---------TSKLNVARLHSK-LLAGNPGEQIKNLETSIQSYKWLIEYCEshTEEI------ 538
                         570       580
                  ....*....|....*....|....
gi 74781347   556 RPLFAQe--LGVCKEMISLLPLKV 577
gi 159115181  911 HKKETS---LKLIGTTIDLLREKI 931
gi 1005949437 555 KSQAQIe--LDLIQEMRELIPKRI 576
gi 348509470  605 GAAVETe--LELSKEMVGLLPLKI 626
gi 47218717   581 AAAAETe--LELSQEMVELLPFKI 602
gi 573885293  597 KKAVETe--LELSEEMAGLLPIKI 618
gi 255072579  588 HGLVGMeqeSDLCEQMCALLPTKI 611
gi 298705397  775 PGIFEQe--LELAEEMAQLQRRNI 796
gi 674577423  625 YKVDMPe--VEIAREMTQLLAGQI 646
gi 340384150  539 KEVFTEe--LGLCKEMVALLPQKV 560
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