Conserved Protein Domain Family
efThoc1
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pfam11957: efThoc1 (this model, PSSM-Id:314781 is obsolete and has been replaced by 463412)
THO complex subunit 1 transcription elongation factor
The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm.
Links
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Statistics
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PSSM-Id: 314781
Aligned: 48 rows
Threshold Bit Score: 243.807
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6CB86        73 LAALLDCITYEsq------ttS---Sd-eK---PLLESTLTLALVEDIFDIHT-VDWCRHFWThYLVSREEQLMNv---- 134 Yarrowia lipoly...
Q6CKD4        84 LSVLLDFCYHLky-------vG---Ee-dE---SKVWAALFFDLTATCILTLTfPHELGQFYT-YLRSRLSWYLE----- 143 Kluyveromyces l...
Q750X0        88 LAAVLD-CVHWmqa-----geG---Aa-gD---AAAWANLYFDLTKSAMQFLAvPDGFLAFWP-YFESRLAWYLQ----- 148 Eremothecium go...
XP_001647171  97 CIVVLDFVYHS----------R---K---NrkiPGNWGSTFFEIFSHCLNLLSwPSEMLDFWP-YTESRIEWFKMg---- 155 Vanderwaltozyma...
XP_003684683 100 LMVLLDYRFLA----------K---EswsD---PKTWATSYFNLFSKILDLLNwPYQVSEFWP-YVESRITWFKIg---- 158 Tetrapisispora ...
CCK71888      96 tATILDFCLHS----------RafrK---N---PDSWINAYFTLFGFPIELLDwSSELLHFWP-YAESRLKWFQMg---- 154 Kazachstania na...
XP_003646123  95 LAVILD-CVHAiqcsskhrgdA---S---W---AGTWANLYFDLTKIVMQFLQfPSSFLSFFP-YFESRLQWYLQgqeme 163 Eremothecium cy...
XP_004177699 164 sALLLDLCFLS----------R---SkrqN---PSLWYRSFFQLFSTVVDLLIwPNELLQFWE-YPQSRIEWFKLl---- 222 Tetrapisispora ...
XP_011276267  92 IGTLLDFSFYI----------R---K---I---GESLYDMPYELIKGVLKEGL-VDWLLKFWS-YFDLRIEEIKRt---- 146 Wickerhamomyces...
XP_002555582  81 fAVIMDLCHHLgr------lrG---Ed-sA---RKLWITTYFELFKQALSFLClPRGHLKFWP-YVETRMHWFQS----- 141 Lachancea therm...

Q6CB86       135 --------SR-------------NQassnsv--trlsgR----KAPGTTLIRLANALLR-------RVS---K------S 171 Yarrowia lipoly...
Q6CKD4       144 --------GL-------------SKepvsnggtnlkmgI----RPPAAKLFFSIDTFFK-------NID---ShslfitP 188 Kluyveromyces l...
Q750X0       149 --------GQ-------------DVvpvrsgenrlvsgI----RLPLSRLLYHCNELVR-------QLE---AqsklntP 193 Eremothecium go...
XP_001647171 156 --------NSlnpvey--gstelIS-------------Y----NAPLSQKLRQWNSTLK-------TIA---NnnklntE 198 Vanderwaltozyma...
XP_003684683 159 --------NNlinenefgsntnlIS-------------Y----RLPLSTSLRKWNTKLNsilndnnKIY---N------A 204 Tetrapisispora ...
CCK71888     155 --------GN-------------RVneefdg-lsrlisY----KPPVAEKLRRWNEMLS-------IIR---YnislntP 198 Kazachstania na...
XP_003646123 164 qfsygdnkLT-------------SG-------------I----KLPLSRLLYYCNELIR-------HLE---AqsklntP 203 Eremothecium cy...
XP_004177699 223 --------GDpssqlp-lgtsnlSS-------------Y----KSPLFNKLRHWNELLE-------KIL---LntefntP 266 Tetrapisispora ...
XP_011276267 147 --------KD-------------NE-------------TlvclRHPGSSLLITINLRIN-------QLYgnhE------P 179 Wickerhamomyces...
XP_002555582 142 --------GY-------------APevkygq--tnlsaI----KAPFSKITFHINKLLS-------TMR---EqsklstP 184 Lachancea therm...

Q6CB86       172 RDAVFAGEILIFLSRAFPLSERSGLNQKGEFNVENI-------T--Vfegyegakehkevdedededddeddnddddede 242 Yarrowia lipoly...
Q6CKD4       189 NHFELVHKLLWWISQLIPINDHCNINRRAKIT-DEY-------P--E--------------------------------- 225 Kluyveromyces l...
Q750X0       194 RHYMVAHKLQWFMSQLLPASENCNYNKSGELM-AQL-------P--E--------------------------------- 230 Eremothecium go...
XP_001647171 199 DHYIMKYKFEKFISEILPISDESNFNRSGTLSTNFD-------T--Gdiwhsskpsndnt-------------------- 249 Vanderwaltozyma...
XP_003684683 205 QSYIMKFKFDKFLSELLPINEESNFNRSGSLYYENV-------N--Srrdvafnnngs---------------------- 253 Tetrapisispora ...
CCK71888     199 AHYKMKYNLEKFISELLPFAEESNFNRSSSVSRNQHsgnpwnkP--Vsstkpatak------------------------ 252 Kazachstania na...
XP_003646123 204 LHYVIINKIQWFISQLLPISENCNYNKKGQI-LSQF-------P--Etlwsnkhsrg----------------------- 250 Eremothecium cy...
XP_004177699 267 NDYILLFKFKHFLSEILPLNEESNINKFSLISKSQD-------SgnVwnehsidkskr---------------------- 317 Tetrapisispora ...
XP_011276267 180 SRDILKAKLLGFTSKIFPAFDKSLINKNFEFNQAHL-------N--Tvqyqkvy-------------------------- 224 Wickerhamomyces...
XP_002555582 185 LHYKLGMKIHWFLSQCLSPMEQANTNRRGNFA-KSL-------P--E--------------------------------- 221 Lachancea therm...

Q6CB86       243 nenedkdvdmgvdemkekvkektatpatskehtqepsdspyaLFWG---------------------LQKYFADPTILLN 301 Yarrowia lipoly...
Q6CKD4       226 ------------------------------------------TFWAphlpalpssp--tilsdwtkiCDDFFLHPLHWLF 261 Kluyveromyces l...
Q750X0       231 ------------------------------------------TLWAqrggklrdarspslfrdwtyfVEEFVLDPVGVMV 268 Eremothecium go...
XP_001647171 250 -----------------------------irrqtssekflydHSKT---------------------RSRLFRDPVYFFF 279 Vanderwaltozyma...
XP_003684683 254 -------------------------------klapkdkfaqdYHLV---------------------KNKIFDNPINLYF 281 Tetrapisispora ...
CCK71888     253 ------------------------------------ekmasdykfV---------------------FDKLLTCPLEFAF 275 Kazachstania na...
XP_003646123 251 --------------------------------lssrspslfaD-WNy-------------------fLEEFIFDPMNIML 278 Eremothecium cy...
XP_004177699 318 -------------------------------tlsardkflddYLFI---------------------LDSCLTNPLGVVE 345 Tetrapisispora ...
XP_011276267 225 ------------------------------------knhafnAFWE---------------------LQRAFANPSGILV 247 Wickerhamomyces...
XP_002555582 222 ------------------------------------------QLWDtkasefedap--affndlrkvEHQFVSDPLGWAF 257 Lachancea therm...

Q6CB86       302 SK---Ep--EVEMNKLQTCLkATVKTLRSHDGSTeiaqGGGTRWAKRDSREGGNrggntsa------agggsgG------ 364 Yarrowia lipoly...
Q6CKD4       262 SHprdK---LTLEPVVHRFV-DEIFVYETELYNL----IKGKNEKHAKQEAAVNgkdfyplnfidnvydepddS------ 327 Kluyveromyces l...
Q750X0       269 SPlreR---QGFEEYTNDII-EFLLEKEQDYYRK----VASAVQGPNLIRQDLHrgliptqas-tnnfrepqdS------ 333 Eremothecium go...
XP_001647171 280 KC---TetkSTIEQYLTPLL-NVMLEAENEFYNQ----IRVTSTRISAANNALNkgypfnydslkikessfvkS------ 345 Vanderwaltozyma...
XP_003684683 282 NLl-eTk--GSLNNYLMPLL-NDLLRVEDLFYNYk----qKETKKLFLMNFQSNk------------------Nypsnfd 335 Tetrapisispora ...
CCK71888     276 KP---FdfkREVERTVSPFL-DALFDYESEFYKt----AKNIHKKNLASLEKLNe------------------Nffsdft 329 Kazachstania na...
XP_003646123 279 SPv-rDr--QGFEEYTNDIV-EFLLEKESEYYKRl----sEVIQQPNLIRQDIHk------------------Nfiasqf 332 Eremothecium cy...
XP_004177699 346 DFldgRh--SDFENTLSSLI-NKTLSYEDEFYSG----IKKHNTKILNANTTLNe------------------Nypiene 400 Tetrapisispora ...
XP_011276267 248 SD---Rt-mSEFMSNASLVY-KKIYDAEERANDGplfvVGKKNYPTNTDKNDYNnsie------------nytK------ 304 Wickerhamomyces...
XP_002555582 258 TDpsqR---LSLERYLLPVI-DEILLHESYFYAQ----IKRKNLRLDRLKHKLHlrasis--------sgsiaV------ 315 Lachancea therm...

Q6CB86       365 --------------------SRDFGNSRGHSANNHSSRTLNAKWLTNPDLFTLQL-SDTN-------------F------ 404 Yarrowia lipoly...
Q6CKD4       328 --------------------RNSIFPSKVEFWKEFNLESTKSENIIQLLPLELDL-FDLRsfqdrieayeydyF------ 380 Kluyveromyces l...
Q750X0       334 --------------------RHSICASKAAFWKHYSEVYATLEDVMHPLPLELCM-EDEHtlnhqletvevdtF------ 386 Eremothecium go...
XP_001647171 346 --------------------SVAIQEKLAKHWDGFYKCYNDRKQLPSITFLDLSS-KNADglfqqysrtdndyH------ 398 Vanderwaltozyma...
XP_003684683 336 iknsn-----gmktpsylklQTHGTKIRLKEWKNFMNQFSSSKLMISPSFLELSK-LDTN-------------Flyyqmi 396 Tetrapisispora ...
CCK71888     330 vin--------sktpnylktSDAVKNKQQELWDNVISVLGNDK-IMRPTVFDLNM-SNPStfynqitktendyY------ 393 Kazachstania na...
XP_003646123 333 vrn---------nyiepqdtRNMISETKVEFWKVFVHNDESMNGIMHPLPLELSI-FDEQnflnqletveldfF------ 396 Eremothecium cy...
XP_004177699 401 qntnsdnnanitkipnymkqNATMTQNRNDFWKNLDDSLSFYANTFQPTWLDLSI-NNVEnfylqftdynndfF------ 473 Tetrapisispora ...
XP_011276267 305 --------------------AHLTEAKRQELQDFYSNRDYNMSFLVNEKKFNEQIrNDQT-------------F------ 345 Wickerhamomyces...
XP_002555582 316 --------------------SRDMTKANKNSTGMSPGNSQNEPFTVRPLMLDQPS-WDPElvlsrlqdpfndfF------ 368 Lachancea therm...

Q6CB86       405 -------RRAIWTQILIFSEFMLSLTEKNKAKIPATATNRSVQYQ--------------Ytls-----aaDEIYFESVVA 458 Yarrowia lipoly...
Q6CKD4       381 -------RKLVISQVYLTFYLLKEIISNDTLVHYYGKIFNQSSLShsskwrveygdnvlN----------KNDSAINFLT 443 Kluyveromyces l...
Q750X0       387 -------RKLVLLQITITCNIVDQILRDKAIYRTYVTRYKNVHSGrai--------------------pnDPPTLFKFFS 439 Eremothecium go...
XP_001647171 399 -------RKQFILQFSSFVSLLNILASSEEASNFYKTCHAKDNPT--------------RkdyddsltptQKSLIAYFQQ 457 Vanderwaltozyma...
XP_003684683 397 kknndffRKQFILQLCFVIGIFLQISESPEVRSFYVNSLQKDNPS--------------KrisnmneesnIQKSLVAFFK 462 Tetrapisispora ...
CCK71888     394 -------RKQFVLQLVFSLNMVERLLTNPNVKELYKNVCQKEDTL--------------KfihfdklspnEIEKSILFCK 452 Kazachstania na...
XP_003646123 397 -------RKNMLMQIAISFNMVDTILRDKATLKAYTARYKNAHYD--------------Rif------ppDPPTLFKFFY 449 Eremothecium cy...
XP_004177699 474 -------RKQFILQVTFALTFIKEFLNSNDIQTFYKNIFKKEDLTere--------silSeln-----ekNKDQIISFCN 533 Tetrapisispora ...
XP_011276267 346 -------RKTFLIQLIIVLGFFSNL-----------------DDA--------------Rvld-----daRASFNLRKAA 382 Wickerhamomyces...
XP_002555582 369 -------RKQVVIQLVIASNLVERVLEDDSIKAFYSSqhyq--------------nldpSvg-------gdSEKTLKDLG 420 Lachancea therm...

Q6CB86       459 HFES-S-GKNKPPYKpghspdfNAVLSRIIPHV-----------FKFDEKWVEWKLE-NCPAYE---KPVMNNIDeVEGV 521 Yarrowia lipoly...
Q6CKD4       444 KKLN-R-ISSFYEIR-------DRQFYELLNHL-----------AQNELDALNQKVG-DFSNLK---DIHWSSDL-ITVP 498 Kluyveromyces l...
Q750X0       440 TAVG-R-IRDFYRVK-------DPQFFDMLNEL-----------LHADESFLFAKAA-NMAPFK---EIAWNTESlGHAP 495 Eremothecium go...
XP_001647171 458 LFET-R-IVSFYKNR-------DPTFLKIILAL-----------IKSDEKLLSSKID-GFKEFS---NLKTSGEEi-KVP 512 Vanderwaltozyma...
XP_003684683 463 NLYEtR-IKAFYEEK-------DPKFMNILNLL-----------INSDSQYLKAKID-GFKEFQ---LDETNAFQf-HSI 518 Tetrapisispora ...
CCK71888     453 HICE-RrVTTFYSFR-------DPTFNNIIVDL-----------IRQNDHSLTQKIE-NFKAFQ---GFALPTVS-KESV 508 Kazachstania na...
XP_003646123 450 STAN-K-IKEFYKQK-------DYEFYEILIEL-----------LHSDESFLAAKSK-NMAPFK---EIKWNCKPiDGKP 505 Eremothecium cy...
XP_004177699 534 KIIElR-VPQFYCSR-------DRKFYDILNSL-----------LYSDNELLIQKMD-GFKKFQ---KFKISEIE-NVPP 589 Tetrapisispora ...
XP_011276267 383 RVATpY-LYDIRNLR-------REA-NNIFNALdkreffgnqmlISSEFTFFQAKLK-QFRNVEtiyNEVQLDDElYDKL 452 Wickerhamomyces...
XP_002555582 421 YFIKdR-VRRFYEQR-------DTVFQGLLDHM-----------LINEDALLELKTKrGFKIFS---SFTFPEKGlSEAP 478 Lachancea therm...

Q6CB86       522 EELITKLGhvrpRWRYEMGTEALTKIMAVECGLS---LL----EkKPdLP-SIGTPQvyidklseldKVKKLDWDFLDEA 593 Yarrowia lipoly...
Q6CKD4       499 TANNAFKK----FGWIKLGNKKLDGLWKVQSGLDlarKY----SeNNrQD-PSELYD----------TIISEYKDKTEKT 559 Kluyveromyces l...
Q750X0       496 EPACSFKK----FGFITMGNKRINDVWKIESGLKrtkDL----AkAReID-PTGVYS----------ALQAVAATAGAAT 556 Eremothecium go...
XP_001647171 513 SIDENFKK----FGFVKLGNKNINNVWKIDSGLD---LI----KtKS-VD-ARENYG----------ILKRKWEEDPNNE 569 Vanderwaltozyma...
XP_003684683 519 VVDRSFKK----FGFIKLGNKDINTVWKIETGID---VI----KeNY-VD-PTKIYN----------ELENKYESGGFEE 575 Tetrapisispora ...
CCK71888     509 PVDYSFKK----FGFIKMGNKQVNNIWKIPSGLD---AV----KsDV-LK-PQELYE----------NLKQKCEGSLEED 565 Kazachstania na...
XP_003646123 506 SFDYEFKK----FGFIKLGNKKVNDIWKIESGLD---RArilsKaNE-IN-PSAVYN----------KLQEEFQNSNVKN 566 Eremothecium cy...
XP_004177699 590 TFNNNFAK----FGFILLGNKNINNVWKLNFNIH---DI----KmDE-QNnPSIVFN----------NLQTVWEQNKKST 647 Tetrapisispora ...
XP_011276267 453 KQEGAFKK----RFWALYGNAQISSHWKIPTGLS---LL----EkDTsk-----------------nTREEKDKNLEILR 504 Wickerhamomyces...
XP_002555582 479 SPKYSFKG----FGWSKFGNKKLDAAWKTETGLQ---NI----K-MDaES-PQAVFE----------ELRTEYKTEDTSV 535 Lachancea therm...

Q6CB86       594 -EqakcledisaADWLGWRAARVGGLWS-----KLGEATVLNEVVNGAKDQKDTRESVDIEEGGAVEVEE 657 Yarrowia lipolytica
Q6CKD4       560 -Dgdet--ttdnVIVKQWQNLRSLRPKYlfefnKVSEKTTLAGFANEELIRNDIESKKRRLAERIESKKK 626 Kluyveromyces lactis
Q750X0       557 -Dad-------sRIVKQWQDLRALRFEYlfelaKVDETTGINGLFDPTLIAASREDKDKRISALHEAYIK 618 Eremothecium gossypii
XP_001647171 570 -Egn-------dKIVTQWKNLRILRSQYlfdfnKVDEDTGISGLFDDSRVAASTERKDEERQNLVKKLKs 631 Vanderwaltozyma polyspora...
XP_003684683 576 -Etkt----endTIVKEWQTLRLLRSKYvfkfdSFDEDKGIKSLFDKSKKVESNKKIEDIIDEMNTEIKE 640 Tetrapisispora phaffii CB...
CCK71888     566 -Ets-------geIVKQWQILRSLRPRYlfefsKMDETVGLRGLFDSSFAQKSEQEKKKLRDELLANIKK 627 Kazachstania naganishii C...
XP_003646123 567 sQnsg----tdgSILKQWQLLRSLRSQYlfefnTIDETTGIAGLFDPNLAKNSKENKAKNTNSYFEKEln 632 Eremothecium cymbalariae ...
XP_004177699 648 -Epqnss-yddnNIVKQWQSLRSLRSEYlfnfkGLDEETGINGLFDSELVQASQNKKDDLIEKLKNKANE 715 Tetrapisispora blattae CB...
XP_011276267 505 -EtikstedqdlKDVVSWKALRLSRQNHlfdfkHVNGSIGLEGLYDHSLKEADDIKRkeeteklekeeee 573 Wickerhamomyces ciferrii
XP_002555582 536 -Sdta-----hhDTVKQWRQMRVLRPQYvfqlgNVDERTGMEGLFNENVVTESQNHKKELRMEREEESRK 599 Lachancea thermotolerans ...
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