Conserved Protein Domain Family
KRTAP

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pfam11759: KRTAP 
Keratin-associated matrix
The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.
Statistics
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PSSM-Id: 314599
View PSSM: pfam11759
Aligned: 16 rows
Threshold Bit Score: 29.7977
Threshold Setting Gi: 296434555
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam11759 is a member of the superfamily cl15662.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81867751    1 MS--YYSGYSGGLGYGY----Gs--SFG-GLG----CGCNsirrlgcgsgyggFgygsgyggfggfgygsgyggygygsg 67
gi 123781217   1 MC--YYGGYYGGLGYGY----------G-GLGcgygC------------------------------------------- 24
gi 88909175    1 MC--YYSNYYGGLRYGY----------G-VLGggygCGCgyg-------------------------------------- 29
gi 296434554   1 MCcnYYRNCCGGCGYGS----Gw--SSGcGYGcgygCGYGsg---------crYgsg----------------------- 42
gi 88909169    1 MC----------YGYGC--------GCGsFCRlgygCGYE---------------------------------------- 22
gi 88909174    1 MI--YYSNYYGGYGYG-------------GLGcgygCGYR---------------------------------------- 25
gi 296434555   1 MS--FDNNYHGGQGYAK----------G-GLGcsygCGLS---------------------------------------- 27
gi 88909181    1 MCgsYYGNYYGDHGYGCcgyeGlgyGYG-SLRcgysSC---------------Cgy------------------------ 40
gi 81879972    1 MCg-YYGNYYGGRGYGCcgcgGlgyGYG-GLGcgygSYYGcgyr------glgCgyg----------------------- 49
gi 218526494   2 CCn-YYGNSCGGCGYGS----Ry--GYGcGYGsgygCGYG-------------Sgygc---------------------- 39
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 81867751   68 yggfGGFGY----GSGYG-GF--GYGSgyggfggfGYGSGYGGY 104
gi 123781217  25 ---------------DYG-SY--GYGC--------CRPLCCRRY 42
gi 88909175   30 -hgyGGLGCg--yGRGYG-GY--GYGC--------CRPSCYGRY 59
gi 296434554  43 --ygTGCGY----GCGYGsGC--GYGCgysssccgYRPLCYRRC 78
gi 88909169   23 -------GCr--yGCGHR-GC--GDGC--------CCPSCYRRY 46
gi 88909174   26 -----GYGCg--yG-GYG-GY--GNGY--------YCPSCYGRY 50
gi 296434555  28 -------------------GY--GYAC--------YCPWCYERS 42
gi 88909181   41 ---gHGYGSrffcGCGYGcGS--GY------------------Y 61
gi 81879972   50 --ygCGYGSrslyGCGYGcGS--GYGS------------GFGYY 77
gi 218526494  40 -gygSGYGCg--yGSGYGcGYgsGYGC--------GYGSGYGCG 72
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