Conserved Protein Domain Family
Inhibitor_Mig-6

?
pfam11555: Inhibitor_Mig-6 
EGFR receptor inhibitor Mig-6
When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.
Statistics
?
PSSM-Id: 314449
View PSSM: pfam11555
Aligned: 10 rows
Threshold Bit Score: 102.957
Threshold Setting Gi: 928179968
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam11555 is a member of the superfamily cl13070.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499033113   883 RPPQIPPRDPL------SQPGSRTPSPMGLVVGSPqqrlysvspntmqaaittcppthtYS-----SYLSTSP------- 944
gi 697826955   654 RPPQIPPRDPL------SQPTSRTPSPMALQVGSP------------------------QQratlcSCLSTSP------- 696
gi 768952124   847 QPPQVPPRDPL------SQPGSRTPSPRGpvvgsphqrvys------vsptamqapattYG-----SYLSTSP------- 902
gi 47227996    813 HPPQVPPREPL------SQPGSRTPSPRGLVVGSPhqrvysvsp------taaqaplssYS-----CYLSTSP------- 868
gi 1042313833  798 rpPQIPPRDPLsqpgsrT------PSPM-------------------------------------------NRtthylst 828
gi 928179968   776 SPPRVPPREPL------SPQGSRTPSPLVPPGGSPl-----------------------------pPRLSSSP------- 813
gi 657523001   863 QPPQIPPRDPL------SQPGSRTPSPMglvvgspqqrlysvspaalqaslsscpaahtYS-----SYLSTSP------- 924
gi 551506037   822 RPPQIPPRDPL------SQPNSRTPSPncavvgslqqric-------svspsthqashsYS-----SHLSTSP------- 876
gi 847126454   832 RPPLLPPRDPL------SQPTSRTPSPMAFQVGSPqqrsnlc------------------splsigTYLSTSP------- 880
gi 597741418   601 RPPQIPPRDPL------SQPGSRTPSPMGLHVGShcsp------------------asiYGs----SYLSSSP------- 645
                           90       100
                   ....*....|....*....|....*....
gi 499033113   945 --GKLMPTTHSFASDPKYAAPKVIQAQVQ 971
gi 697826955   697 --GKPMPTTQSFALDPKYATPKVIQAQGK 723
gi 768952124   903 --GKLMPTTHSFASDPKYAAPKVIQAQGK 929
gi 47227996    869 --GKLMATTHSFASDPNYAAAKVSQAQGK 895
gi 1042313833  829 spGKLMPTTQSFASDPKYAAPKVIQAQGK 857
gi 928179968   814 --GKTMPTTQSFASDPKYATPQVIQAPGP 840
gi 657523001   925 --GKLMPTTHSFASDPKYAAPKVIQAQGk 951
gi 551506037   877 --GKPMPTTHSFASDPKYAAPKVIQAQGR 903
gi 847126454   881 --GKLMPTTQSFASDPKYATPKVIQAQGK 907
gi 597741418   646 --GKLMPTTQSFASDPKYAAPKVILAQGK 672
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap