Conserved Protein Domain Family
Ax_dynein_light
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pfam10211: Ax_dynein_light (this model, PSSM-Id:313442 is obsolete and has been replaced by 463000)
Axonemal dynein light chain
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Links
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Statistics
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PSSM-Id: 313442
Aligned: 90 rows
Threshold Bit Score: 83.7506
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A0C8X4         59 DEILNKFFPPRRf--eHEGHFFKQVVSVNDVKRDELNQLEAELDQRLI---ERQARKSGI-CPVRE------------DL 120 Paramecium tet...
19_pfamImport   1 ---LSLLFPIKVf--kKTDKTLI-QLISEDTNLSDL----ELIQAVLK--------------NIENnnmdklnffyveNI 56 
Q8ILP2         68 NDPIYYIFPSKCi--kVKKAEHI-SYVSRVTNDEDIVLCLKRIYEVLSnmySKNM-------IIKE------------EY 125 Plasmodium fal...
Q389G1        155 ETLLYTLLPPQRivceETGETIVKSVSLEQPSRVEVAKLHERTLQQLQ---QRRAREWGI-CPLRR------------EI 218 Trypanosoma br...
Q4DPW6        146 ERVLYTLLPPRRtvckETGNTILQCVSTEPSSRVEVADLHERLTERLR---QRRARDSGI-CPIRR------------EV 209 Trypanosoma cruzi
Q4DXE3        141 RNTFCS---TREf----gESKWMKVAAIDHTSRLDCVHLQDHLNRRCK---EENARPSGVlCTIRE------------GI 198 Trypanosoma cruzi
XP_008186366   14 NKVFEYIYPPEEw--mEDGVKWRRVASTEPADRNHVLALAEDLKSNLS---YWHARMHGV-CLVRR------------EL 75  pea aphid
XP_001582280   42 RDVLNSLFPPIEf--eQDEIKYTRSISTAPISKTDVTKLRTELDTLLH---KNKTKPKGI-DIIRS------------EL 103 Trichomonas va...
GAA47226       20 lqaLSKFFPPVRy--kEMGTKWVKHVSAKQATPIEMTHVKQEVDRVLK---VRCSRKAPL-CVIRE------------DV 81  Clonorchis sin...
KMZ78213       68 NEPLYNMFPLKCv--rDKKVDQISYV-CRVTSEEDATACLKKIQDIVS---KMYAQNM----LIEK------------DF 125 Plasmodium viv...

A0C8X4        121 HSQL---FE---EIIRQSAINCPERGLLLMRVYDNLKLTFAAYQTLYAGSVVFGNRKAA--ESE----IGKSEQDSK--- 185 Paramecium tet...
19_pfamImport  57 IFEL---LD---EIIRQVICEYPKRGFAVLLITNELQKNINYYKNLID----------IieHNNemntQGFKEMNEKnnl 120
Q8ILP2        126 LNEL---LNiltELCRQISVTCFQRGLLLKQLFNYNIMLLFEYHKLVKSSLAFNLKKQM--KQNdilnNFHKEIEKKnn- 199 Plasmodium fal...
Q389G1        219 YTEL---FD---ELIREITLEEPARGVLLLRIRDEMNQTLAAHRALAERTLLFASKQRM--EPP----EDISALRQR--- 283 Trypanosoma br...
Q4DPW6        210 YAEV---FD---ELIRQITLEEPTRGILLLRIRDELYQTLAAHSSLAERAMYFASKQRE--EAG----EGMDELKRR--- 274 Trypanosoma cruzi
Q4DXE3        199 YTDG---LR---ELIRQTTVLCPERGLLLAELATEMQQTTNKYDILFDSASQYAVRKAI--ERD----MRSYLFDDK--- 263 Trypanosoma cruzi
XP_008186366   76 YTQC---FN---ELIRQVCVNSIDRGQLLIKIRNEYNASIKAHKLLFESGLIFRIKHTT--LDD----HKDDVTEKD--- 140 pea aphid
XP_001582280  104 YSQC---FE---EVIRQVTIDSNARGRLLFRIRNHYKTLIQSYKDLNELALNFGANKNI--QVT----LGMDQLLDY--- 168 Trichomonas va...
GAA47226       82 LSDL---IR---EILRQVTIDCPEQGLLLRRILDHNEMEFNAYETLLRFTDAFVGRKWA--EWQ----HWKADRTRQ--- 146 Clonorchis sin...
KMZ78213      126 LEDLlsvFM---ELCRQVSVTCFQRGSLLRQLFNYNSMLLFHYHKLVRSSLTFNLKKEI--KRS----HTMSELRQE--- 193 Plasmodium viv...

A0C8X4        186 -IADYDKKKIYLENQKILLENELDAIQRSFKEIRELEEKRMESEMQFLKQQTKHLEHF 242 Paramecium tetraurelia
19_pfamImport 121 iLQDLLVEENKLKEKLIDVQTRLELLKEENKKKLQENKNKKEIQYDLLKHNESLLD-- 176
Q8ILP2        200 -------siNSLTKEIINTEEMMEQEKINSEKEIAEVNIIYQNKIDKLKKNNQRKKDE 250 Plasmodium falciparum 3D7
Q389G1        284 -IKELEEEREELLVKRRMATVREEQIQSALLDENTARVKLWQDETCYYRRANRQVSQR 340 Trypanosoma brucei
Q4DPW6        275 -IHELEEKRLELIVRKKAVQVREEQILRAIEQENNTRSKLRQDELGYYRRANRQLTQR 331 Trypanosoma cruzi
Q4DXE3        264 --KSMESEVRRLENRVNELRAKRDGMIKRFEEQKQSEQNRHEEEVKYLKKANQQIISE 319 Trypanosoma cruzi
XP_008186366  141 -IQDIEDAHVKLKKKLVDANNKYNKLKTDLKNELNNLKDANQHELSFFNRNHEALKDQ 197 pea aphid
XP_001582280  169 -NKKLREKRRELELEANNLQIQLDGLEKRIQENKQIREKEFADEIAFLKKQGQSIKMI 225 Trichomonas vaginalis G3
GAA47226      147 -IYELEDTKRILEFQATELKHKVDQLEKKNQEMKIKWDAARMEEVKYYKKTGEHLRAQ 203 Clonorchis sinensis
KMZ78213      194 -MERKKEAINSLRSEILDTDRLIEEERANAEREMSEVNIIYQNKIDKLKKNNQRKRDE 250 Plasmodium vivax India VII
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