Conserved Protein Domain Family
HVSL

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pfam09749: HVSL 
Uncharacterized conserved protein
This entry is of proteins of approximately 300 residues conserved from plants to humans. It contains two conserved motifs, HxSL and FHVSL. The function is unknown.
Statistics
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PSSM-Id: 313045
View PSSM: pfam09749
Aligned: 110 rows
Threshold Bit Score: 307.605
Threshold Setting Gi: 388853555
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
pfam09749 is the only member of the superfamily cl28765
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121920743   48 PPLP-AAFHDLYTTNA---R---ISTSDNPELHGGRKR---AMPHVEGNWPSHVYLEWNPSQAESD-------------- 103
28_pfamImport   1 DALSnERLSRSSS----------------PARAIGNS----TGKVVKGDWLCYCFVEVLVDPSLGR-------------- 46
gi 74608369    61 PPIP-SSVYDKYQIPPntdK---YIERTDNGMSLGAIKgsdVFKRNIGKWSCFLYIEYRPSSTERE-------------- 122
88_pfamImport   1 LPLP-NSFKLVSQEEV----------KDDPKKHEGRIR---SYPHQRGNWNSLIYVPCMRNLVNKSyfapylfkhknrkn 66
gi 24638477    29 PKLQ-ESFHELYKKKP--------KTFDSPEFHEGRIR---GQKHIEGLWFVQTYLEVDLSKKVKK-------------- 82
gi 552928442   82 PPLP-SDFLQLYPDKK---RkdyTKHIDDPSKHQGRIR---SKPHVEGDWATHVYVDVTLTEEADH-------------- 140
gi 568259888    3 kkLP-APALKLHSTTT---P---SEEERKPEDHEGRQR---SFPHERGIWASYVYIDYEGQEGLER-------------- 58
gi 891587305   25 PKLP-DFIKDLYRK-----K---RKTFDSPNFHEGRKR---TKAHVEGLWAVQIYLDVDFDNSSKQ-------------- 78
gi 156848603   43 PTVP-STVLDKYYVSPnilK---YTEEMSNLV--GIKT---GFR--TGQFRSFIFLEWRPTSLQRQ-------------- 97
gi 388853555   55 panlplkrvtkrklppleadslqrqdddspsdltpapasnsSKKVARGDWLCYCFVDVPLDPSSSA-------------- 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121920743  104 -----NLHGLIQHVKD-----AIdaqnkerpkktpV--P-KIIPSLQ-----SELGA-PL----------------P--- 145
28_pfamImport  47 -----CIQDSHAHLQE-----QLg-----------T--KhTLLDLRH-----S--DH-PTtdegasaanpspssqgQ--- 92
gi 74608369   123 -----MISKTLSQFNQ-----SWqkk-------fpG--TdIFEPLHY-----TTLGV-PV----------------P--- 158
88_pfamImport  67 gpfdlLRDQIIDLCQP-----KI------------------------------EMKK-IE----------------E--- 91
gi 24638477    83 -----GIREFLN-----------------------S--QsRFQSLLC-----SEHNV-PR----------------R--- 107
gi 552928442  141 -----IINKIEELAKE-----VV------------SkdGiKIISCIEdhqdnNSLNE-LD----------------Pngh 181
gi 568259888   59 -----MQQE----WNQ-----EL------------R--AaGIK----------DFQP-VG----------------H--- 80
gi 891587305   79 -----KIQEIIA-----------------------S--QsEFRSLFT-----SEFGV-VR----------------S--- 103
gi 156848603   98 -----QLVKSINQFNEnltktKG------------S--NfRFDPLFI-----SSLGS-PE----------------P--- 133
gi 388853555  121 -----LIRDCHKHLQE-----QL------------Gt-ShTLLDLIH-----SDASPgAD----------------Paee 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121920743  146 -----LHVSLSRTLQIKTE-DRDVFLDALRSRLR---RA----SVAPFQFQF-R-GLKWVPNFQRNRWFLVLSIEKPAN- 209
28_pfamImport  93 -----LHISLTRPFTVRSY-ERDEYVKVAAAEVQrlkAT----VG-SFPFTF-S-RIAYLANDDASRHFMVLEVGAGr-- 157
gi 74608369   159 -----LHISLTKNIPFDSEtQRDRFYNILVPKVAqlrQH---------LVQF-EdTLRFYGSPQTTSVFLGYNVAQSvk- 222
88_pfamImport  92 -----PHISLTRTFILLYH-WIDDFVAAVKKSLGi---------mLRYDVQF-D-GLKIYCNEERNRTFLAMSV---GFg 151
gi 24638477   108 -----LHLSISENYRINYS-TKNQLVHKWEQYTNnlnYR----TL---KFRL-G-KMCLLFNDEKTRMFLAFECKFSd-- 170
gi 552928442  182 ceetkLHISLSKPLFLKYH-QIEHFWNKLRNGFL---NW------KRFSLSF-A-NITSFSNDDKNRSFLALEVGKGSN- 248
gi 568259888   81 -----LHLSLTKTFTIRHH-NIVPFVGSLQELL-----G----VHRRFRLEL-D-GVGVYVNEERTRTFIGVRIAEVSY- 142
gi 891587305  104 -----LHLSLSELFRIASD-ERKAVLTIWRRECQ---HL----QHRAIRYKL-Q-DPCLLFNDDRTRMFFVLKATFESA- 167
gi 156848603  134 -----LHVSLSKSIVCESItQRNLFYRELKKELQ---SV----QIQPFTLTFtN-KPLVLTAKQDSSMFLCLEVNRSHR- 199
gi 388853555  157 --agyLHVSLTRPFTVRSS-ERDEYAKIAKAELQ---RLketiGRNSFPFSF-S-RIAYLNNDDASRHFMVLEVG-SGR- 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121920743  210 -NE-LNRLLDACNKAT--------R-H-CGHPGLYvgghgdgpmessnentgnkrrkgqdteeesvdRSDRFHVSIAW-- 275
28_pfamImport 158 -DK-FHRLSTALSTEL--------R-RaFRAKAYY--------------------------------DEARFHASTAC-- 192
gi 74608369   223 dNI-IKDITDNIESALidsglsesD-KmVTVPSFS-------------------------------------HMSIAkls 263
88_pfamImport 152 kME-ITKSVQLLDKCL--------S-E-YKLHPFY--------------------------------NEASFHMSFLW-- 186
gi 24638477   171 -EN-YKDLISHASDCM--------K-E-FTNRNLR--------------------------------EDFLLHISFAS-- 204
gi 552928442  249 --E-LKSMVDHVNKVA--------E-D-FRQKPFY--------------------------------ENPRFHASILW-- 281
gi 568259888  143 -PP-LDRLVTELDECL--------L-E-YKLPRYY--------------------------------EDRSFHISLLW-- 176
gi 891587305  168 -DL-LKKLLEISNNLM--------E-K-YEGKELR--------------------------------KDFLPHVSFAW-- 201
gi 156848603  200 -TKiLKPIQDAISSAL--------EtT-FSNQSDIimn--------------------------fqvSNEYLHMSIAQ-- 241
gi 388853555  227 -DQ-FHKLSTALSKVL--------H-RaFRAKAYY--------------------------------EEARFHASTSCle 263
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121920743  276 ---NLE--Epdp-----ewTALIKNI----Dvser--------------------ikqpQ---AsiDVVKVRIGNVVHNI 318
28_pfamImport 193 ---VLDstPdqs----dhaTQALASR----Fstivadieae---------hgprlrqcrP---VwaTRIGIQVANRVSYV 249
gi 74608369   264 -----------------naPKDILDK----Vgyadsnqmakqi----qdyveispnqqpV---FyvSSIKMNKNRELLTI 315
88_pfamImport 187 ---CLGdkk--------keLEELLPE----Mnkvfeanl------------ndsfdvtiP---V--TRYICKIGNKMYNI 234
gi 24638477   205 ---SLT-------------NEDEYQN----WvsqdreshffktmneiintkiqkdqfseS---FivDSLKLSIGHLIFTF 261
gi 552928442  282 ---ALG--Ets-------iDRSLCDaiketeyf------------------esitqhvfN---I--ENMVCKIGNKTFTL 326
gi 568259888  177 ---TLG--Dqse-----ivTSRLPKL----Teqfeeiye------------deytdltqT---I--RKLWFKCGNKLYPF 225
gi 891587305  202 ---AHA--Kqgd----feaWESCDREnlrfIeletllkqfe---------samlksvslE---N--NSMKMVMGHKIHSV 258
gi 156848603  242 ---MTN--Cpps-----saN----------Lksssidwep----------fhgldeikvP---C--KEVKCLINRQLYSI 286
gi 388853555  264 itkTLD--DdaeppelreaGEALGPR----Fsdivndvek----------kwgpqlrkhPptwA--ARVGIQVANRITYV 325

                  .
gi 121920743  319 D 319
28_pfamImport 250 D 250
gi 74608369   316 p 316
88_pfamImport 235 N 235
gi 24638477   262 P 262
gi 552928442  327 D 327
gi 568259888  226 q 226
gi 891587305  259 t 259
gi 156848603  287 P 287
gi 388853555  326 D 326
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