Conserved Protein Domain Family
WTX

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pfam09422: WTX 
WTX protein
The WTX protein is found to be inactivated in one third of Wilms tumors. The WTX protein is functionally uncharacterized.
Statistics
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PSSM-Id: 312801
View PSSM: pfam09422
Aligned: 15 rows
Threshold Bit Score: 435.441
Threshold Setting Gi: 380876857
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam09422 is the only member of the superfamily cl26639
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856   57 GMVRSRTHDGL-ADA-VLESGKKEDagggea-----qgkdapS------------------------RAAGGLGGSASSS 105
gi 142984753   89 GLSKSKTHDGL-SEAaHGPEDVVSE-----------------G------------------------TGFSLPLPELPCQ 126
gi 380876857   60 ELVRSKTHDGLiTDTpSELDSHRKEesass-------dqlhaG------------------------TPDGVSTAPLRSS 108
gi 142984668   94 GMVRSRTHDGL-AEVlVLEGSKKEEppggsdhsgarpipgppK------------------------PSGPGLGSLASSS 148
gi 597777416   59 ELARSKTHDGLvTDVpSDLEGSKKEdscssdll-------------------------------hsapvegvSLAPVRSA 107
gi 984125062  101 GMVRSRTHDGL-AEVvVLEGSk--------------------KeepraggdsgrgrgggrpnpgpprAAGTGVGSLANSS 159
gi 47210741    74 EIIRSKTCDGL-MSSnSDADGQR-E-------------------------------------------GLASLEAGPVRS 108
gi 551503686   77 ELVRSKTHDGL-TGSnNEAVGQRGE-------------------------------------------GLTSLEAGPVRS 112
gi 542193429   77 ELVRSRTHDGL-TSSnNDADGQRGE-------------------------------------------GLAGLEVGPVRS 112
gi 513022112   89 SLRKSKTHDGL-SEVaHGPKD-VSE-----------------G------------------------TGFSLPFPESPCR 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  106 VAKSHSFFSLLR-----KNGRPENGKAAENAEQRAGGRQKKGLKGIFSSMRWHRKDKIGKEERGE----ASEipsg---- 172
gi 142984753  127 FPSSQSAHGALEtgsrcKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEpgakGPE-------- 198
gi 380876857  109 ITKSFSFFSLLR-----RSSSRAGDGT------TTVGRRGRGLKGLFSSMRWRRKPQIQEDTle---vaKEVkegdlils 174
gi 142984668  149 VAKSHSFFSLLK-----KNGRSETGKGDHAEASKAGGKQKRGLKGIFSSMRWHRRDKRGKEEEEKa--vRAAgpgn---- 217
gi 597777416  108 ITKSFSFFSLLR-----RNSTRVGDGAA------TLGHRGRGLKGLFSSMRWRRKPPPREDSSEIqevaKEVkegdvilp 176
gi 984125062  160 VAKSHSFFSLLK-----KNGRSENGKGDPADASKAGGKQKRGLKGIFSSMRWHKKDKRGKEEEKEa---HAAgqgs---- 227
gi 47210741   109 LSKSLSFFSLLR-----RGSFKSSEGGG-----SGLVRRGRGLKGFFSSMRWRRKDKSNEKEIEElvgkRKEdgki---- 174
gi 551503686  113 LSKSLSFFSFLR-----RGSFRTSENGG-----TGIVRRGRGLKGFFSSMRWRRKEKTSEAEGEEvegkKARdtdat--- 179
gi 542193429  113 LSKSLSFFSLLR-----RGSFRSSENGG-----AGLVRRGRGLKGFFSSMRWRRKDKTNEGDGEEaeakKDKdgdaa--- 179
gi 513022112  126 FPSSQSAHGALEidyrhKKSVAGSTKKAGVDKLPPVPKPKKGLKGFFNSIRRHRKSRIAGAEQSEpnakASE-------- 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  173 ------limpG--SLTASLECIKEETPKPLSEtpngagDTGVESQQEKRGGDAC--VSAEEPqa------gGGESRDSKT 236
gi 142984753  199 ----------R--VRARPHEHVSSAPQVPCFE------ETFQAPRKENANPQDApgPKVSPTpe-----psPPATEKMAC 255
gi 380876857  175 s-ssgsvkteK--DMTLTLEPLPQVFEESPLPgdsdkwKVASMQGIQGTNEVECgnCGPSVSqq---------------- 235
gi 142984668  218 ------lvlpG--SLTASLECVKEEPPRAARRpdspgqDASRHAAGEPAGGEQAp-ASAESApericleagSPTGSGDQS 288
gi 597777416  177 stsnkvetleD--SVTLTLEPTVRVFEECPTEdnsgtwDKNSLEEVKSSNEE----------------------SRKSSC 232
gi 984125062  228 ------lilpG--SLTASLECVKEETPRAACEpetpsqDAPRDPAGELGGGEEVpaSA-DRApartcreaeSPGCPNDKS 298
gi 47210741   175 ------ddseKlkDVTLTLEP----------PphhhheDCGDAGTEPN---TETpsTSVTLTpsqc-vagsEPSAELDS- 233
gi 551503686  180 -----esetlK--DITLTLEP----------PphhhqeDCASAETGSNLQASDTptTSVTMTpthc-vampGPSGEPDS- 240
gi 542193429  180 -----daekvK--DITLTLEP----------PphnhqaDCGDAEAGPNLQALETptTSVTMTpphc-vampGPSGEPDS- 240
gi 513022112  198 ----------G--ARARSHEHVSSSP-LPCSE------ETCQATTKENAKPQAVlgPKISPApe-----psSPATEKIAC 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  237 PPGEDpaAAARRLEELCGERPDPGAGEVGTAKDAAITGDIpittippvephc--dsgqetaaapdpSS--VDPPSEQSID 312
gi 142984753  256 KDPEKpmEACASAHVQPKPAPEASSLEEPHSPETGEKVVA--------------------------GE--VNPPNGPVGD 307
gi 380876857  236 -----htVTEESPAPSPLRVQTGGLQNHKHSSSTHLSSIPtcalt----------------ppmehST--ADPQSEQSVD 292
gi 142984668  289 SRGED--AEGHRREEKPGAALESGAGEVQAAEDASKTGDVpiktvplvdseg---gsgrasavpdpSS--VDPPSDPSAD 361
gi 597777416  233 SLVQE--ITEESPAPSPLRVPTEGPLRANTSGSACLTSIPasamt----------------pplehSS--VDPPSEPSVD 292
gi 984125062  299 ARGED--AAGHRRAEKPRAPPESGAGEVHTAEDASRTGDVpiktvplvdsec--gsgrasavpdpsS---VDPPSDPSAD 371
gi 47210741   234 -------PFPYTPTDSPLRPPI-------QKTKASISSLTpslatp---------------pldrcST--GDPPSEPSVD 282
gi 551503686  241 -------PFPYTPTDSPLRPSI-------QKAKASISSLTpslttppldrcsigdqpsepsvdrlcSIlfTDVTSLKSFD 306
gi 542193429  241 -------PFPYTPTDSPLRPPI-------QKAKASISSLTpslatp---------------pldrcST--GDPPSEPSVD 289
gi 513022112  254 KNLEKsiGISASPLVLPKLAPESSILEESHR-QTGEKIIA--------------------------GE--LNPPNGPMGD 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  313 RI--C-LMFADV-----------------TSLKSFDSLTGCGDIIA------------------------DQEEDVGggs 348
gi 142984753  308 PL--S-LLFGDV-----------------TSLKSFDSLTGCGDIIA------------------------EQDMDSM--- 340
gi 380876857  293 RL--C-SMFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DPEEDSGngg 328
gi 142984668  362 RI--C-LMFSDV-----------------TSLKSFDSLTGCGDIIA------------------------DPEEEAG--- 394
gi 597777416  293 RL--C-SMFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DQEEDSG--- 325
gi 984125062  372 RI--C-LMFSDV-----------------TSLKSFDSLTGCGDIIA------------------------DQEEEAG--- 404
gi 47210741   283 RL--CsLLFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DADDEg---- 315
gi 551503686  307 SLtgCgDIIADAdeegpggnggsgtssssSGGGGGSLSTNVGRAVGltsatthasptkppipsqitqpmfSVPQ------ 380
gi 542193429  290 RL--CsLLFTDV-----------------TSLKSFDSLTGCGDIIA------------------------DADEEg---- 322
gi 513022112  305 QL--S-LLFGDV-----------------TSLKSFDSLTGCGDIIA------------------------EQDMDSM--- 337
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  349 GGCEKST----------------PGAGKLGA----PKK------------------------------------------ 366
gi 142984753  341 TDSMASG----------------GQRANRDG----TKR------------------------------------------ 358
gi 380876857  329 SATSSGT----------------GSSSGGCM----GRRlsgagtnsercspakpplppqvss-----------lasihas 377
gi 142984668  395 PSCDKHV----------------PGPGKPVL----SKK------------------------------------------ 412
gi 597777416  326 NGGSATSsgtgsssggcggrrviGAATERCS----PVKpplppqvtsrvsispy-------------------------- 375
gi 984125062  405 PSCDKHA----------------PGPGKPVL----SKK------------------------------------------ 422
gi 47210741   316 PS----------------------------VpsslPARarapps------------------------------------ 331
gi 551503686  381 ------------------------SSAPVCL----PARtrvppp------------------------------------ 396
gi 542193429  323 PVGNGGS----------------GTSSSSSG----GGGgsvgvgigrvvgitssispskpplssqmsqpmfsvsqnsapa 382
gi 513022112  338 TDSMASG----------------GQRANRDG----TKR------------------------------------------ 355
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  367 -----------------HPTMVAYQGGGEEMASPD-----------------------QVDDTYLQEFW---DMLSQTEE 403
gi 142984753  359 -----------------SSCLVTYQGGGEEMALPDdddeeeeeeeeveleeeeeevkeEEEDDDLEYLWetaQMYPRPNM 421
gi 380876857  378 cympahqrpraapkkpqGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPQKDE 431
gi 142984668  413 -----------------NASVVAYQGGGEEMASPD-----------------------QVDDTYLPEFW---DMLSQTED 449
gi 597777416  376 --lsshqrmssspkkpqGSGIVAYMGGGEEMASPE-----------------------GVNDADMQGLW---HMLPQKGE 427
gi 984125062  423 -----------------NPSVVAYQGGGEEMASPD-----------------------EVDDTYLQEFW---DMLSQTED 459
gi 47210741   332 -----------pqhhppGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPSTGD 374
gi 551503686  397 -----------pqqhsaGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPSAGE 439
gi 542193429  383 slpartraqpqpqqhppGSGVVAYMGGGEEMASPE-----------------------GVDDADMQGLW---HMLPSTGD 436
gi 513022112  356 -----------------SSCLVTYQGGGEEMALPDddeeeedev-----eleeeeevkEEDDDDLEYLWanaQMYPRPDF 413
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  404 TetgGGGGGGGGTKT------------PEGLKENRGTegaqnrvavkrggln----------------------qipihl 449
gi 142984753  422 N---LGYHPTTSPGHhgymlldpvrsyPGLAPGELLT------------------------------------------- 455
gi 380876857  432 D-------SPAPRRAepv------lhhAPArlekrppqvkalglskip----------------------vsgssktgkq 476
gi 142984668  450 Q---GQGTQEGAAKAatasd---iklaPETSSDTRCGeaakdmssvkrrrlh----------------------ripies 501
gi 597777416  428 D-------SPALPRSdpi------vhhPPGrqekkhpqvkslglskip----------------------vcgisktgkq 472
gi 984125062  460 Q---GQGPQEGAAKAaaale---tkvvPETSKDARSVeaskdvslvkrrrlnr--------------------ipieshp 513
gi 47210741   375 N-------SPALPRShqlpsstptstyPPRATSGLPSsylpsgprsvdrkqsqvktlglskipvvggattkagktplsha 447
gi 551503686  440 S-------SPALPRQyqpssstltstyPPR--SNSPSalrpsaqrsaerkapqvkslglskipvvggagsragkpplpha 510
gi 542193429  437 N-------SPALPRShqpssstptstyPPR--TNPASsylpsasrssdrkvpqvkalglskipvvggagsraakpplpha 507
gi 513022112  414 N---LGYHSTTSPAHhgymlldpvqsyPGLAPGELLT------------------------------------------- 447
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380876856  450 nnkeeqkgREKEQHEGVPNSDEGYWDSTTPGPE---EDS---TTSIQKETLPRDSYSGDALYDLYaEPDENPPGGPP--- 520
gi 142984753  456 --------PQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVRRDCLPRDSYSGDALYEFY-EPDDSLENSPP--- 520
gi 380876857  477 qpsrpsppPVDKELQDAPPSDEGYWDSPTPGPE---DED---STFLRRDGLLRDSCSGDALYDLY-DPDSPSAAGSD--- 546
gi 142984668  502 qqkeepkhPEKEHQEGVPNSDEGYWDSTTPGPE---EESisnSSSSKKVVIPRDSDSGDALCDLYvEPEASPATLPA--- 575
gi 597777416  473 qsahpsppPTDKELHDAPPSDEGYWDSPTPGPE---DED---NGFTRRDGLLRDSCSGDALYDLY-DLDSPGAGGSD--- 542
gi 984125062  514 keqpkhpeKEKEQQEGVPNSDEGYWDSTTPGPE---EES---ASSGKKAGIPRDSYSGDALYDLYaDPDGSPAVPPA--- 584
gi 47210741   448 hghnvtspGEKE-----PLRDEGYWDTPSATPTatpDDSg--LQQNQRIGLSRDSCSGDHLYDLYnDPEEEGEGCEQe-- 518
gi 551503686  511 hgrhpvspGEKE-----LLSDEGYWDTPSATPTatpDESg--LQRNQKIALSRDSCSGDHLYDLYnDPEEEGED--Qrgd 581
gi 542193429  508 hgrhptspSEKE-----PLSDEGYWDTPSATPTatpDESg--LQHNQNMALSRDSCSGDHLYDLYnDPEEEAED--Qggd 578
gi 513022112  448 --------PQSDQQESAPNSDEGYYDSTTPGFE---DDSgeaLGLVHRDCLPRDSYSGDALYEFY-EPDDTLENSPP--- 512
                         730
                  ....*....|....*.
gi 380876856  521 EEE-VTCMPRSK-PVS 534
gi 142984753  521 GDD-CLYDLHGR-SSE 534
gi 380876857  547 -DD-ASSPTKSAgDLK 560
gi 142984668  576 TED-PPCLSRLK-PVS 589
gi 597777416  543 DDDnMSSPTPSTgdlk 558
gi 984125062  585 NEE-TSCLSRLK-PVS 598
gi 47210741   519 GQS-QSSLSPAS-ECK 532
gi 551503686  582 NDV-NSTPSPSA-EFK 595
gi 542193429  579 EDP-NSSPSPST-EYK 592
gi 513022112  513 EDD-CLYDLHGH-SSE 526
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