Conserved Protein Domain Family
HUN

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pfam08729: HUN 
HPC2 and ubinuclein domain
HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci. HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails. This domain is also referred to as the HRD or Hpc2-related domain.
Statistics
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PSSM-Id: 312308
View PSSM: pfam08729
Aligned: 46 rows
Threshold Bit Score: 25.2704
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam08729 is the only member of the superfamily cl16007
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 74621330     37 KRRQRTDE-------YDYNDPFIEPFEGETEMV------MIECNLEDFFVYKGEL 78
gi 124443189    59 GAMQKDFDyekgqnvYDQDDSFIDDEE-------------IDKENHAMVIPETEL 100
gi 74777926    223 GANRSREDy------YDVFDDFIDDSELVDDLGlsldelYSRNADRGNHTADQGD 271
gi 74976363    147 GDPTSYFKlgggdmyYDINDPFLDDEEMYKELNktkneiILTRQIEDEYSVWSAD 201
gi 74952090    221 GDPTSYLKkggddmhYDMDDPFFDDSAMLSELKmsksdiLLKRAMEKEFSDWSED 275
34_pfamImport    1 KKRRKKKNras--eyYDTADPFIDDSELAQDERt----fFAQTKQKGFYVSSGQV 49
gi 74682264    340 KKKKRPTD-------YDLEDPFIDDSEIMIDAPt----hYARPAREGFFVHSGPL 383
32_pfamImport    1 -RKRGPNAvlgrfggYDTNDPFVDDSEVALYEPr----fYARPKREGYFVCAGPV 50
33_pfamImport    1 KRRKVNDDkyd-igqYDVRDPFVDDSELNIDEPt----hFAKPKADGFYVTQGTV 50
gi 1028573094  171 KPVKKTTNvadaecnYDLEDDFIDDSEMFTDAMeg--veEVPEWDFGYFVWHGSV 223
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