Conserved Protein Domain Family
MAP2_projctn

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pfam08377: MAP2_projctn (this model, PSSM-Id:312025 is obsolete and has been replaced by 429957)
MAP2/Tau projection domain
This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.
Statistics
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PSSM-Id: 312025
Aligned: 4 rows
Threshold Bit Score: 1636.26
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P11137        377 DKMAEAPPSEAMTLPKDAHIPVVEEHVMGK--VLEEEKEAINQEtvqQRDTFTPSGQEPILTEKETELKLEEKTTISDKE 454  human
XP_008765419  460 DKVADVPVSEATTVLGDVHSPAVEGFVGEN--ISGEEKGTTDQE---KKETSTPSVQEPTLTETEPQTKLEETSKVSIEE 534  Norway rat
XP_013012917  457 DKVAEAAASEAITLPTDAHVPVVEESVTEK--GLGEETGVTPQE---KTEISTLSGQEPALAGRELQPKLEEKTSISDKE 531  domestic guin...
XP_007666799  306 DKMGDMPMSTVITQSMEVHKLTIRESHGQRgcGVGEDKDIPRWEndlRKEHFLPNGQKFALFESEPYRKPEEKSSVLV-- 383  platypus
P11137        455 AVPKESKPPKPADEEIGIIQTSTEHTFS--EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSS 532  human
XP_008765419  535 TVAKEEESLKLKDDKAGVIQTSTEHSFSkeDQKGEEQTIEALKQDSFPISLEQAVTDAAMATKTLEKVTSEPEAVSEKRE 614  Norway rat
XP_013012917  532 AVPKEHEPSKLRDEETGIIQTATEHTFLqeEPKSQEHATDMLKQDSFPASLEQAMTDPTMISNTLEKVSIEPAALHEKST 611  domestic guin...
XP_007666799  384 SLPQDSKLLKGLDEEKSTTRSLGGQTIKkeEPPSKGAQVDQFRRDSFPGAQGRDLMLAAALSETLDKMPVAPSPRSDPA- 462  platypus
P11137        533 IQELFEMRVDDKD-KIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSP 611  human
XP_008765419  615 IQGLFEEDIADKS-KLEGAGSATVAEVEMPFYEDKSGMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSP 693  Norway rat
XP_013012917  612 LQELFQEKVADKDsKVEGVGAAQSTEIDMPFYEDKSGMSKYFETSALKEEVTKSIQLASDYYELSDTRESAPESVESIST 691  domestic guin...
XP_007666799  463 -RSLSQEREIGKDiRADKAGAPPPTE-ERPLDEDKSGMSKYFETSTLKEEATKSLQQDSDYYELSDSKESAYESYDTVAP 540  platypus
P11137        612 MHKNGDKEFQTgKESQPSPPAQEAGYSTLAQSY----PSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 687  human
XP_008765419  694 KNQQDEKELLA-KASQPSPPAHEAGYSTLAQSYtsdhPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 772  Norway rat
XP_013012917  692 MREDGDKGSQAeKEPQPSAPAQEAGYSTLAQSY----PAEVPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 767  domestic guin...
XP_007666799  541 MFKDGDQES--------SAPACEVGYSTLAQGY----PSDIAEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 608  platypus
P11137        688 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPV------ 761  human
XP_008765419  773 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKIPCFPI------ 846  Norway rat
XP_013012917  768 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPAVEKAPCFPI------ 841  domestic guin...
XP_007666799  609 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPGLEKAPGFPTegreek 688  platypus
P11137        762 ----------------------ESKEEE-QIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSR 818  human
XP_008765419  847 ----------------------ESKEEEdKTEQAKVTGGQTTQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSR 904  Norway rat
XP_013012917  842 ----------------------ESKEEEeKLEEEKTTGGENTQVEAPCESPFVAKDYYKNGTVMAPDLPEMLDLAGTRSR 899  domestic guin...
XP_007666799  689 eeegeeeeeeeeeeeveeaeqaEGQKKAgKAVEV-----ESSQVESPSESPFLAKEYYKNGAVMAPDLPEMLDLAGTRSR 763  platypus
P11137        819 LASVSADAEVARRKSVPSETVVEDSRTG-LPPVTDENHvIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFY 897  human
XP_008765419  905 LASVSADAEVARRKSVPSEAVVAESSTG-LPPVADDSQ-PVKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFY 982  Norway rat
XP_013012917  900 LASVSADAEAARRKSVPSETVIEESSTG-LPPVTDENHvIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGDSGSFY 978  domestic guin...
XP_007666799  764 LASVSADTESARRKSVPADVGGHDSGAGvLSPIGNKNHvAVKDDSQMEDLGYCVFNKYTVPLPSPVQDSENLQGDSGLFY 843  platypus
P11137        898 EGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK--- 974  human
XP_008765419  983 EGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDSK--- 1059 Norway rat
XP_013012917  979 EGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFGAEKETSP-----TSGLLREFDQERKGNDKLDTVLEKSEEHADAK--- 1050 domestic guin...
XP_007666799  844 EGADDKLRRDLATDLSLIEVKLAATGRVKQDVGGEKEPSPPVSGDKAGLSRELDQDRKATDKLDTVLEKGEEPMDSKetl 923  platypus
P11137        975 ---EHAKKTE-EAGDEIETFGLGVTYEQALAKDLSIPTDASS---EKAEKGLSSVPEIAEVEPSKKVEQGLDFAV----Q 1043 human
XP_008765419 1060 ---EHAKESE-EVGDKVELFGLGVTYEQTSAKELITTKETAP---ERAEKGLSSVPEVAEVETTTKADQGLDVAAkkddQ 1132 Norway rat
XP_013012917 1051 ---EHAKEAQ-EAGATVDMFGLGVTHTEPSAKELTASKDAAS---EKAEKGLSSVPEVAEVEPSKKTEHELDFAAtkadE 1123 domestic guin...
XP_007666799  924 lpeEHGKLGPgEVVTKVEMVSSEPAVDLASIQVMTQSQDTSPfmtEKVEPLLGSVPEVAETEPLPKAEPRTDPSAkadpS 1003 platypus
P11137       1044 GQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQE 1123 human
XP_008765419 1133 SPLDIKVSDFGQMASGMSVDAGKTIELKFEVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQE 1212 Norway rat
XP_013012917 1124 APLDVKISDLGPIMARLDVDAREIAELTLEVQQEQVPPSEAPREADVFLGVEAGHLKDGARVSETEVKEKVAKPDLVHQE 1203 domestic guin...
XP_007666799 1004 QPV-VQVSDFGSTAAEQDGASQGPA-----AQQEGAGLARGGQDVELLVGAEAGDGKEGTRGSEAEIKEKVAKPDLVHQE 1077 platypus
P11137       1124 AVDKEESYESSGEH----ESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFI-Q 1198 human
XP_008765419 1213 AVDKEESYESSGEH----ESLTMESLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADSSIDEKAEVQMEFI-Q 1287 Norway rat
XP_013012917 1204 AVDKEESYESSGEH----ESLTMESLKPDEGKKETSPESSLIQDEIALKVSVEVPCPPAVSEADLAAQEPADVQMESIpT 1279 domestic guin...
XP_007666799 1078 AVDKEESYESSGEHdvtpEGGAGEPSKPDEGKKEPAKEPPTLPDEVTVR-ALEAELPP--SSVDAVLVEGADIQMEPI-Q 1153 platypus
P11137       1199 GPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEE-----EEIEAQGEYDKLLFRSDTLQITDLGVSGAREEF---- 1269 human
XP_008765419 1288 LPKEESTETPDIPAIPSDVTQPQPEAVVSEPAEVRGEE-----EEIEAEGEYDKLLFRSDTLQITDLLVPGSREEF---- 1358 Norway rat
XP_013012917 1280 LPKEDSRETPDIAVTASDVPEPQPEAAMAQPAEVQSEE-----EEIEARGEYDKLLFRSDTLQITDLGAPSSRENV---- 1350 domestic guin...
XP_007666799 1154 QPKRDSQEAPGISITPSEALEP---TLLKPGSEASADEnkegqEEVEARGESDRLLFRSETLQLADLSIPTDREESekrg 1230 platypus
P11137       1270 VETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPH----------------------- 1326 human
XP_008765419 1359 VETCPGEHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQPEEERRPYPH----------------------- 1415 Norway rat
XP_013012917 1351 LETCPGERKGGIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEMERRPSPQ----------------------- 1407 domestic guin...
XP_007666799 1231 VEDVP-EHKGGIESVVTIEDDFITVVQTTTDDGESGSHSVRFAALDQAEVESRPSPPggeeeeeeeeeeeeeggggggge 1309 platypus
P11137       1327 -----DeEEFEVEEAAEAQAEPKDGSPEAPASPER-EEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIM 1400 human
XP_008765419 1416 -----D-EELEVLMAAEAQAEPKDGSPDAPATPEK-EEVPFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIL 1488 Norway rat
XP_013012917 1408 -----EeEELEEEVAAEAQAEPKDGSPEAPASPER--EAALSEYKTETYDDYKDETTIDDSVMDADSLWVDTQDDDRSIM 1480 domestic guin...
XP_007666799 1310 eeeeeA-SEPEAEELMDDRPEPKEGSPEAPASPDKeEEVGLSEYKTETLDDYRDETTIDDSIMDADSLWVDTQDDDRSIM 1388 platypus
P11137       1401 TEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHS 1480 human
XP_008765419 1489 TEQLETIPKEERAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHS 1568 Norway rat
XP_013012917 1481 TEQLETIPKEEKADKEARRPSLEKHRKEKPFKTGRGRISTPERKIAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHS 1560 domestic guin...
XP_007666799 1389 TEQLETVPKEEKSEKEARRPSLDKHRKEKPFKAGRGRISTPERKIAKKEPSTVSRDEVRKKK-VYKKAELAKKTEVQAHS 1467 platypus
P11137       1481 PSRKFILKPAIKYTRPTHLSCVKRK 1505 human
XP_008765419 1569 PSRKLILKPAIKYTRPTHLSCVKRK 1593 Norway rat
XP_013012917 1561 PSRKFILKPAIKYTRPTHLSCVKRK 1585 domestic guinea pig
XP_007666799 1468 PSRKFILKPAIKYTRPTHLSCVKRK 1492 platypus
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