Conserved Protein Domain Family
CTNNBL

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pfam08216: CTNNBL 
Click on image for an interactive view with Cn3D
Catenin-beta-like, Arm-motif containing nuclear
CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localization signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.
Statistics
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PSSM-Id: 311918
View PSSM: pfam08216
Aligned: 103 rows
Threshold Bit Score: 91.4325
Threshold Setting Gi: 927381079
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam08216 is a member of the superfamily cl07010.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MFV_A         28 KRLLQIIDR-Dge----eeEEee--ePL---DESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMH- 96
gi 955494560   94 tQILDIMDGgDas----sgAP-----PA---DVPALRKQLLRFERAITKNAEMRTKYAADPARFIESEADVDAEIKSLL- 160
gi 465795009   93 ERILEIMNR-Hat----dgAEsgaraAD---DVAETRQLLVRLERAIEKNQAMRLKFPDDPRRFIDSEADLDSALRALV- 163
gi 1022869871 109 KEVLSIMEG-Sgnde-qlpGE-----DL---TPQSVRKQLLNLEKAVNKNRDLRTRFPSDPEKFVDSEFNLLEAIRAVF- 177
gi 294867331   20 dDIQELIKK-Neq----teVK-----SL---DVEGCAALVRKVASLVKENQRLRIKHSDDPTKFLESEVSLAEEIRRLT- 85
gi 953453889  113 KQILEIMDD-Drd----psEA-----AM---TLQGLRKMVSVLEKAVAKNVEMRAKFAGNPHKFVESEIALDTALHALL- 178
gi 927381079   29 ERVLEFLKR-Dtv----vePQ-----KIveyNVQWVKNSLTKLGELVTSNLQMREKHSSDPTKVMDSEFELFQGLKVWSe 98
gi 343427148   94 QQILDIMDS-GdptpanqtTS-----VT---DLPALRKQLLRFERAITKNAEMRVKHAHDPARFIDSEADLDAELKSLL- 163
gi 1023184150  92 STILDIMDR-Aps----ptSS-----QN---DLPGLRKQLLRFERAINRNAEMRVKHATDPARFIDSEADLDAELKGLL- 157
gi 475521099   12 KRAEQEEEQ-Aat----dgLD-----VL---DLRAAKRLLLGFERRLRDNLEARMKHPDDPARFADSELALHAETDRLR- 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
4MFV_A         97 ---VVATMP-D-L---YHLLVELNAVQSLLGLL-GHDNTDVSIAVV 133
gi 955494560  161 ---VLTTQP-ErF---YAEFVQLGGAASLVGLL-SHENADIAAAAI 198
gi 465795009  164 ---LLTTNAgA-L---YPVLVHQGSAASVVGLL-AHENADMAAAAI 201
gi 1022869871 178 ---LFSTAP-A-La--YPLMLENSTPNTFADLL-SHENMDVPIAVV 215
gi 294867331   86 ---ELAVNPaE-L---YPAFVAGHGGRVLVGLL-QHANVDICAEAL 123
gi 953453889  179 ---LLTQSPgS-F---YPELIKLGIISTLVDLL-SHENVDISIAVI 216
gi 927381079   99 isiALAEAP-D-YqqcYTVLVASPVFAEVVGLLaSHPNIDVREQVL 142
gi 343427148  164 ---VLTTQP-V-Af--YGEFVKLGGAGSLVGLL-SHENADIAAAAI 201
gi 1023184150 158 ---VLTTQP-A-Vf--YGEFVRLGGPASLVGLL-SHENADIAAAAI 195
gi 475521099   78 ---LLAGAP-A-L---FPDLVPLGLASSLSSLL-THDNADLAAAAA 114
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