Conserved Protein Domain Family
RIX1

?
pfam08167: RIX1 
rRNA processing/ribosome biogenesis
Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion. This family is usually associated with NUC202, pfam08166.
Statistics
?
PSSM-Id: 311889
View PSSM: pfam08167
Aligned: 93 rows
Threshold Bit Score: 93.8084
Threshold Setting Gi: 301121945
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam08167 is a member of the superfamily cl20353.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74613479      7 DLRV-LCRRLAST---------PVD-DLPHICPLLVSHVLRCGEVLSav-----peTkakdkssetaTLVHRLRTHITTL 70
gi 260796465     1 manV-LLTSLSEK---------DGKtSLPWAIEVANEHQLLQSEQNAq-----------------------dWVSHINTS 47
gi 301121945    17 lsSV-LALAFPSE---------LEN-DHAALESFLTQQAALREALERhnvfglvtdG----------KALTKWQTRLLQL 75
gi 1032299402   16 KPKI-LRNLLSEYvpnekqpltNFL-SLSKVVSTISTHKLLSESPPAsidqkl---------hakskSAVDDWVARLSAL 84
gi 685347417    16 KPKI-LRNLLSEYvpnekqplvDFQ-SLSKVVSTISTHKLLSESPSSsadqkki-------qakpskSAVDEWVERLLAL 86
gi 1002856794   17 KLRLxGGGGGGRRpkpg--galPPA-ELATVLDAVRTHGLLTERLPGthdpkl---------aeawrAAVDAWVERIGEL 84
gi 721655314    17 KPRL-LRAVVSERlpka-gstvPPA-ELFSILEAVRTHGLLTESHLDaldhkl---------aeawrAAVDSWVDRVVEL 84
gi 514711569    18 KPRL-LRAVVAERlpqpggaelPPV-ELASVLDAVRTHGLLTEALPDrapadpk-------laeawrAAVDSWVERVVAL 88
gi 573878688    19 LLSA-LQEEQPGH--------------LPGLLASYREHGGV-SAQSAgv-----vgN---------------LIGFSNAR 62
gi 512889457    15 ITGL-LERDLSEG-------------ELAETIRGLREHGALRGEGLPaa-----msG---------------LLSSCNSR 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74613479     71 LAGKSASGRFAAVFLVKAVVDVGG-WESLRASDVWIRGLIGILGKP--DPLVS--------KELCVITLTKIYSLL-QSY 138
gi 260796465    48 L--GTAKTRLEGLCLLGTVVQQCSaGTFIQHGTTWIRMLTQVLQAY--DSPLT--------LQMASHVLGSVVQQA-AQY 114
gi 301121945    76 VEGSSAARR-VGWELLQTTVRQSPlERLEALAVKLLERIVKVLKQQ--QSSKTqdddaeyaTAAACGVAQALLLHVdKFN 152
gi 1032299402   85 ISSDMPDKSWVGICLIGVTCQECSsDRFFKSYSVWFNSLLSHLKNPa-SSRIV--------RVASCTSISDLLTRL-SRF 154
gi 685347417    87 VSSDMPDKCWGGVVLIGVTCRECCsDRFFSSYSVWFNSLLSHIKNPe-SSRIV--------LVASCTSVSDLLTRL-SRF 156
gi 1002856794   85 VQSDMPCSRWLGICFLGLTFQECSnERFAESYSNWFEKILSNLQGPs-SEQLV--------IIVSCTSMSDLFVRM-ARC 154
gi 721655314    85 MASDSPYSCWLGTCFLGVTFQECSnMRFLQSYSDWFEKILRNLQEQs-SLELV--------TAVSCTSMSDLFVRL-ANF 154
gi 514711569    89 VVSDSAYSCWLGTCFLGVTFQECSnERFAESYSNWYEKILPNLQQEpsTLQLV--------TVISCTSMSDLFVRL-AKF 159
gi 573878688    63 LSST--KTRFQGLCLLSVLVRDSSsDVFQQHCLSWLRAVQQVIQSQ--APLPS--------VQLAVTILQDLLQYS-SQL 129
gi 512889457    61 LISA--GTRVEGLSLLALAVEESPtGVFEQHCVSWLRSILQIIQSQ--DPPRV--------VSLAVFVLRSLLAHS-SAL 127
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74613479    139 QTLVREMATPtLPSFVTAMLNLVK-----PpasskapkvptsFV-DTVAGSLSKIVSLYPTTTRPFNAQIRAAFKAYIAP 212
gi 260796465   115 PEVAREVATThIPTLVQCLLGAQD-----H------------QWfPSALEALQSCMKNFPGPCGSSKGKVESLICGLMDT 177
gi 301121945   153 PDTRREVLEL-LGKLLQPLVALLRqtsnsP------------LV-IAQLDLVATLLRSSPNSLRSYAIKIESACVDLLFT 218
gi 1032299402  155 SNTKKDAVSH-ASKLILPIIKLLDed-ssEa-----------LL-EGIVHLLSTIVLLFPAAFHSNYDKIEAAIASKIFS 220
gi 685347417   157 TNTKKEAVSH-ASKVVLPIIKLLEee-ssEa-----------LW-ESIVHLLSTIVILFPAAFHSSYDKVESVIASKIFS 222
gi 1002856794  155 LNLKKEASSF-AGRVVEPVLLLLNgn--------------gpVA-NEAVDLLRTVIKLYPSSVNRHYNKVESSIATNVMS 218
gi 721655314   155 LNLKKEASSF-AGRVVELLLLLLNen--------------gpVV-DEAVDLLTTVIKLYPSSVNRHYNRVESAIAAKIMS 218
gi 514711569   160 SNLKKEASSF-AGRIIESVLRLLNen--------------glVA-DEAIDLLCTVIKLYPSSVNRHYNKVESTIAAKVMS 223
gi 573878688   130 PELSREIGLNsIPGILTSLLGLKQe-----------------cH-LGAMEGMTACMTYYPRACGSLREKLGAYFLSKMDS 191
gi 512889457   128 PELSREISTNhIPGLLTSLLGLRRq-----------------cL-VPALEGIRSCFISYPRACGSLRGKLTAFLLSLIDA 189

                   ....*
gi 74613479    213 TMSDA 217
gi 260796465   178 SQPRL 182
gi 301121945   219 CERDN 223
gi 1032299402  221 AKTSS 225
gi 685347417   223 TKTSS 227
gi 1002856794  219 SEVNV 223
gi 721655314   219 TEVNV 223
gi 514711569   224 TEVNV 228
gi 573878688   192 DNPKI 196
gi 512889457   190 ENQQI 194
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap