Conserved Protein Domain Family
PRMT5

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pfam05185: PRMT5 
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PRMT5 arginine-N-methyltransferase
The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
Statistics
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PSSM-Id: 310055
View PSSM: pfam05185
Aligned: 30 rows
Threshold Bit Score: 528.745
Threshold Setting Gi: 75002871
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam05185 is the only member of the superfamily cl27061
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       189 GEEKTWMWWHNFRTLC-DYSk-rIAVALEIG--ADL-PSN----HVIDRWLGEPIKAAILPTSIFLTN---KK-GFPVLS 255
gi 124473364 151 EITKDWIKYNQIRQEL-QFN---IPILLRLK--KEM-TTK----NEQRKWLSENIRFVHLNQDLFSMN---DQ-GAPKLD 215
gi 122068191 167 GADDTWNWWNNFRSYA-DFDt-hVKVALEFT--ADI-PEK----REIYRWLGEPVDAVVLSSNIFLTN---AN-NYAVLS 233
gi 74800839  104 TVESPWCWWNTFRCHA-DYNp-tVKVALELT--ADV-PKQ----EEIFRWLGEPVDAIVLPANIFLTN---AK-NYPVLS 170
3UA4_B       215 EHVDLWTIWADFRKNCgNFSgvyFQVALTIS--SEL-PDEltelKLVDRWKAEPLAAFVIESGLFISG---RN-GEASIP 287
gi 75002871  191 EQLSEWQITNTIINASp-----nTKIGLSLKidSNLsRISi---EDYSRFFGEPIKCMFINYDFFESK---RS------G 253
gi 74953024  200 DSLNT---WNMIYELC-GFSd-kLKVCLKLQ------PVE----TDLELWLSEPVKCVVLSEETILTD---KR---VVLN 258
gi 74842609  185 DIINGWNLWAKFISYC-NFNyshLGLALELSniNNIdLSN----IQLDVWKSEPVKLIIIPLDAFLLD---TKtGYPYLP 256
gi 74878077  192 HIINGWNIWAKFISYC-NFDfsnMNVAIEFVniKDInINN----INLDIWKSEPVKLIIIPLDVFFID---SKtGYPYLP 263
gi 156083515 150 aSNTAWEYWRAIHQMT-NYSs-qLKVAIIID--EG---NT----EYLERWIAEPLAAVIIRESLFKKHgdvVS-LDPSII 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       256 KMHQRLIFRLL-KLEVQFIIT------------------------------------------------G-TNHHSEKEf 285
gi 124473364 216 DIQNQFLTSYFqFENYISISA------------------------------------------------K-SPQIDLAD- 245
gi 122068191 234 KAHQELLVLFYrTFGCHFIVKa-----------------------------------------------N-PDDKRLVH- 264
gi 74800839  171 KAHQSMLNLFYrTFSCHFILKa-----------------------------------------------N-PSDGHLGH- 201
3UA4_B       288 SAHINLLKHLWtTDALRIVLRat---------------------------------------------tD-TFKYNTSIk 321
gi 75002871  254 SSISEVLKHSMrAKVPISIYFnd---------------------------------------------nI-SSNVKSIIk 287
gi 74953024  259 KAVSSQLSILM-KNNVKILLDsnlnykslisssvsv------------------qnsdsdnfveevvmrDlESEIDVKD- 318
gi 74842609  257 KKLKDFLIYFFrKNIEVLLITnedinkmnnhfihlkneycneyqhnicnnemdsydindnnnnnnnnynIsNSIHTKTNn 336
gi 74878077  264 KKLKDLLIFFFrKNIDVVLTArkkggdnyiyntesggiylegkki-eidemnmiektnnryklgkdakeNpEAKNEFVDn 342
gi 156083515 218 KSLKFLL-----MYDVKIMLSgsfdfhllrease-----------------------lrsndslellslK-DLDVPPMPn 268
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       286 csYLQ----YLEYLSQNRP------PPNAYELFA-KGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLL 354
gi 124473364 246 --HRQ----YLIHLFKNQQ------PLSEQAHLA-SEFFDELQIPLQPYKDNLNSGTYEVFEQDKIKYDLYEDACRKYLK 312
gi 122068191 265 --YAD----YIKYILRS----------NYKKDPM-QGYDDLLEIPLQPLYDNLDSFTYEVFEKDPVKYILYQNAIEEALR 327
gi 74800839  202 --YVD----YIKYTIQH----------NYVKNPL-HGYEDLLQIPLQPLYDNLDSFTYEVFEKDPVKYIYYQNAIEQALL 264
3UA4_B       322 seYSQalrhAVRNVNYRSRpdvgegSNDSTHYLNvIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALK 401
gi 75002871  288 nsYNN----IVKFIKS-FP------PLSSKQKYE-YNYIDVLQMPLQPLSNNLKSIEYEVFERDHIKYEKYFHAVKLFLS 355
gi 74953024  319 --VLK----AVKRCYSRIG------PLTIRELYG-RGYEDLFQVPLQPLRDNLDSSTYNEFEKCSFKYNCYDQAIHSFIS 385
gi 74842609  337 nyYLKcciyYIKRLFMSIE------NFDNDSLFD-SFYWDYLQIPLQPLKDNLSSQTYEVFEKDRKKYEQYELATSKYLS 409
gi 74878077  343 iyYLKcciyYLKRLFMSIE------NFDTHTLFD-SSYWDYLQIPLQPLKDNLSSQVYEIFERDKTKYEKYELAISKYLC 415
gi 156083515 269 giTVKeaigTIKAIYAAMP------PLTEAEKFK-QGFYDVLQEPLQPVRDNLETATYENFERCTRKYAQYEAAISAWLK 341
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       355 DRVPEEekd-----------------------tnvQVLMVLGAGRGPLVNASLRAAKQAD--R--------RIKLYAVEK 401
gi 124473364 313 NVKKAE-----------------------------INILMAGAGRGGILERVIFAAQGAK--C--------KTKIVALEK 353
gi 122068191 328 DRVPSSeiq-----------------------trtSIIMVVGGGRGPLVRAALNAASKSK--R--------MVKIYVVEK 374
gi 74800839  265 DRVPEAdra-----------------------tatTIIMVVGGGRGPLVRAALNASQTTN--C--------KVKVYVIEK 311
3UA4_B       402 DLGADGrk--------------------------tvVIYLLGGGRGPIGTKILKSEREYNn-TfrqgqeslKVKLYIVEK 454
gi 75002871  356 ENNIKSee---------------------------ikVLIVGSGRGGLIKSAFNAFSYIGi-N--------SFKIMCVEK 399
gi 74953024  386 TKLISLnqlsklnsn------------isysspvnYIVYVLGAGRGPLVEVVMEVFKRNNipTn-------DFVVFALEK 446
gi 74842609  410 NWKKGKkinnknkqsnknknnnnnnnmeeqqndhkITIFVVGAGRGPLVDTTLSALQKNEm-T--------DYEIYAIEK 480
gi 74878077  416 DELNKKkynndnlnlsneennnsdkskisksderhFIIFVVGAGRGPLVDCTLKALETNKi-N--------NYSIYAIEK 486
gi 156083515 342 DYLNGKigsqdenvr------------qdcgkskaPVIYIVGAGRGPLVDCSLRALAYHN--Ve-------EYSIFALEK 400
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       402 NPNAVVTLE-NW-QFE---E---WgsQ-VTVVSSDMREWVAPE----------KADIIVSELLGSFADNELSPECLDGAQ 462
gi 124473364 354 NPYAYMTLVfQKkRQK---Q---W--KdVEIVLDDLKSWQTEL----------KFDLIVSELLGSFGDNELSPECLMWAQ 415
gi 122068191 375 NPNAIVTLS-ALiN-E---L---WkdKnIELISTDMREFEPPE----------KADILVSELLGSFGDNELSPECLDGAQ 436
gi 74800839  312 NPNAIVTLT-AHiN-E---L---WrdRnVELISTDMREFNPPE----------KADILVSELLGSFGDNELSPECLDGAQ 373
3UA4_B       455 NPNAIVTL--KYmNVR---T---WkrR-VTIIESDMRSLPGIAkdr----gfeQPDIIVSELLGSFGDNELSPECLDGVT 521
gi 75002871  400 NRNAVLTLK-AKmNYK---DnanWe-K-VDIINSDIRTVQLDE----------KYDLIISELIGSFGDNELSPECLIFAQ 463
gi 74953024  447 NPYTMLTLD-HKiQNN---R---Wt-N-VRLIYSDMRDLNRGMvqsnlnnaskTVHLVLSELLGSFGDNELSPECLYGFE 517
gi 74842609  481 NDSAIIILN-NRvQTE---E---W--KnVKVIHSDIRYLDIPK----------KADIIISELLGSFGDNELFPECMDGIK 541
gi 74878077  487 NDSAILVLK-NRlLNE---K---W--KnVKVINSDMRHLKIDI----------KADLIVSELLGSFGDNELFPECLDSME 547
gi 156083515 401 NPAAVFALK-HKiATNaikG---Wd-K-VQIIFHDMRTLKPTI----------PADLVLSELLGSFGDNELAPECLDGVQ 464
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       463 H-----FLKDD-GVSIPGEYTSFLAPISSSKLYNEVRAcrek---------------------------drdpEAQFEMP 509
gi 124473364 416 R-----FLQPD-AVSIPCDSVSYCVPVSCPQLHAKVKK-----------------------------------SYGYDSS 454
gi 122068191 437 K-----HLKPD-GVSIPCKSTSYLNPCMAPKIYSQIRSmekslha----------------------kdrivtSRYMEGT 488
gi 74800839  374 K-----HLKDS-GISIPCKSTSYINPCFGSKVYNQVRLlersphw----------------------kdrvisSRHMEQA 425
3UA4_B       522 G-----FLKPT-TISIPQKYTSYVKPIMSTHIHQTIKAqsipylsraipshgrgepeldedemwiqkypqghvRNNMDQI 595
gi 75002871  464 R-----FLKPS-GIMIPQRYTSYLEPISCRKVWNNAVSyl--------------------------------kSKTLEIP 505
gi 74953024  518 RsfnslFSQGVrLEFIPGSYTSYVMPLHCPQIWAKIKSfe--------------------------------nTKNFHMP 565
gi 74842609  542 K-----FLKDD-GISIPMNCVSYLEPISCSALYHKVMEnn--------------------------------iSGGNESF 583
gi 74878077  548 K-----YLKED-GISIPQNCLSYVEPISCAKVYYKLCNnn--------------------------------fPGNNENF 589
gi 156083515 465 HafykaFPNHH-VTFMPYSFISYAEPIYAPKVWSTIKQmq--------------------------------vEKHFQQP 511
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4X61_A       510 YVVRLHNFHQLSAP--QPCFTFSHPNRD-P----------------M--IDNNRYCTLEFPVEVNTVLHGFAGYFETVLY 568
gi 124473364 455 YVVHYQKYYTIHDI--QKCMQFKHPDFN-N----------------E--NQLAQEQNLVFECKQDLLIHGMAGYFTSKLY 513
gi 122068191 489 YVAYLKNAYHIDNP--QAVFEFVHPNLD-P----------------I--IDNSRYKTLRFKAQLDCVMHGFCGYFDSVLY 547
gi 74800839  426 YVAYQKNAYHIDNP--QPLFEFVHPNRE-Sd---------------Dp-IDNNRYKTVRFRAALDCVMNGFTGYFDTVLY 486
3UA4_B       596 YVVYLSKYIPLAETt-KPVFTFEHPNF--M----------------N--SSNERSDSIEFVMDRNADLMGFAGYFDLQLY 654
gi 75002871  506 FVSRLKSHYKISLEgpKEVFSFHHPTE--In---------------EeiMENEIFTTVEFTSRAESTLHGFLGYFKCDLY 568
gi 74953024  566 YTVYLKTYYNVGTMy-MDCFSFEHPKTQdSkt------------sqI--SILERYKVIKFVARSDCYVHGFGAYFKCTLF 630
gi 74842609  584 YVVNMYSYTKISQEssKECFFFQVPPIHtKq--------------dN--SHNYRYKNINFKIKMDTYIHGFLCYFKSQLY 647
gi 74878077  590 YVINLYSYYKISEGp-KECFYFDIPSKNiKn--------------dN--SNNNRYKNINFKVINDSYLHGFLCYFNSKLY 652
gi 156083515 512 YIVALNKICKITDGp-KPCFKFAHPNEYvTkwkqeddtfpgmpqgnN--DHNNRYMCMTYKANLNCFIHGFAGYFECMLY 588
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*....
4X61_A       569 QDITLSIRPETHSPGMFSWFPILFPIKQPitvreGQTICVRFWRCSNSKKVWYEWAVTA 627
gi 124473364 514 EDIELSTHPNNSTPDMYSWFPIYFPFEKPvniakKQKLKFTIKRVNNEEGVWYEWFNSV 572
gi 122068191 548 KDITISIHPFTHTKGLASWFSMFFPLTEPvqvraGEEIVVNFWRCVASHKVWYEWNITA 606
gi 74800839  487 KDITLSIHPFTHTKGLASWFSMFIPLTDPvqlrkGDEITVHFWRCVASHKVWYEWSLSA 545
3UA4_B       655 KTVMLSIEPSTHTPGMVSWFPAVIPLRDQlrvgeGDRISLKIDRKVDNTGVWYEWHVEK 713
gi 75002871  569 NEVGFSTLPSdLTNNPISWFEFFIPISNPillkkFDKLTFNIWRKSNKDRVWYEWLVTK 627
gi 74953024  631 DKIEISTLPQ-DSENLKSWFPMFFPLEIPfpvkkSQVITLHIWRKVNDLKVWYEWAFTT 688
gi 74842609  648 DDVYISIEPKTHTPNLHSWFPLYIPINKIqflkkGQNLSFSIWRLTDHQKIWYEWCINE 706
gi 74878077  653 NDVYLSIEPNTHTNNLHSWYPLFIPINKIiflknKQNLSFSIWRLTDNHKIWYEWCVNE 711
gi 156083515 589 NDIKISILPg-VMDDQISWFPMFFPLISPvyvkeSQSIMVHFWRKHDERRVWYEWTLTl 646
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