Conserved Protein Domain Family
Sarcoglycan_1

?
pfam04790: Sarcoglycan_1 
Sarcoglycan complex subunit protein
The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.
Statistics
?
PSSM-Id: 309778
View PSSM: pfam04790
Aligned: 59 rows
Threshold Bit Score: 155.03
Threshold Setting Gi: 1005938858
Created: 17-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam04790 is the only member of the superfamily cl20274
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41018012   43 GWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTvDGMGNLRVT---------K--K----------GIRLeGISEFLL 101
gi 308486998  27 AKRLIATLICLFVLFLVTLITLALNIWIITTLRMTsNGIPFLRFY---------H--SfnektkemekTIEMsGNRIEFE 95
gi 541046211  37 EKRLWILLGFMVVLTALTVAVLIMNIFMIRVLSMStRGMKNLQFHsrydtksgeE--Es---------VLQFtAERVHLG 105
gi 762142178  51 GRRAYLLYCLVVILIVLALLNILMTAGILYMLKVTtAGLEMLEFI---------PadSn---------LLRFlAGTT-LP 111
gi 156386262  98 GRKIWCFLAVLYLLALMCIINLIILSIMYSVLQIKtDGMKSLSFF---------E--Ng---------MLRWtKKS-DLE 156
gi 390370932  54 GRKRFLAYFLLFLIYAVAIANLVLTVLIVLALRIDqNGSDVMEFR---------G--Eg---------GVK--YKTDVMA 111
gi 954376026  45 GRKLIALLVCVGLMWLIAIVNLVCNILLVMFLKIGnQGMDGVQFG---------R--Tvdg-----kpVVQFaASETYFQ 108
gi 514680604 132 RRRLWCVVGLVVLCGLLSITALIGSIWIINQLNIDsRGMHAM-VI---------D--Gd---------TVGF-------- 182
gi 312066980  49 KKRLWILLLCLVVLTIITLILLILNIFIIHVLGMStRGMKHLQFH---------S--RyhpdtgkedvVLQFsANEIHLG 117
gi 71991474   26 AKRLIATLICLFVLFIISLITLALNIWIISTLRMNsNGVPFLRFY---------Y--SfnektkemekTVEMtGNQLKFE 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41018012  102 PL--YVK--E--I---HSRKDSPLVLQSDRNVTVN---ARNHMGqlTGQL-------------TVGAE-A-VEAQCKR-- 152
gi 308486998  96 KV--VSN--K--I---VGFPEKDITITAPRMLMTS---RQN-----DSLL-------------VMSEKlC-KLERVNSfq 144
gi 541046211 106 KV--VAK--SgtV---RGSPGKDLTIHGSRVIING---AKD-----RSRL-------------LLQEGlC-RFENIDQ-- 154
gi 762142178 112 SV--KVF--QggV---GSRHSSSIQLDSDKQIVFN---T-SSIKkkDVEG-------------LIGPNkI-QFQSLDE-- 164
gi 156386262 157 IVtaYKH--E--I---GGFRDQSLDIESQGKKIIL---HGGPTTn-SPQV-------------HVNSDgSgVFKAKKG-- 210
gi 390370932 112 ER--VLS--D--IgefGGYKGQDLEVHGDGQPVIL---Q--HMIghGSSV-------------EFSGAnT-TLRSQEG-- 164
gi 954376026 109 HM--VSKtgT--V---GGYRDTDLNADAAR--IVI---RTNNSTtlPVGL-------------IIDENrI-RMQNVNT-- 160
gi 514680604 183 ------------L---HEFGADEVFVRGEAEVYIVrgaPENPTIfrSDQVrfralsqsqssqsTLDVGgAdVHLSSPR-- 245
gi 312066980 118 KV--IAK--SgvV---YGGAGKDLAILGSRVIISSts--------aQSRL-------------VLQDGiC-RFENSNQ-- 166
gi 71991474   95 KV--VSN--K--I---VGFPDKDITITAPRMLVTSrq--------nDSLL-------------VMSEKlC-KLERVNNfq 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41018012  153 --------------FEVRAS-EDgRVLFSADEDeiTIGAE------KLKVTgtegavfghSVETPHIRA-EPSQDLRLES 210
gi 308486998 145 vsplkhdplnmlsfFQVISP-KDgRTLFSARHP--TVTIDkr--ikKLAAE---------RIITNKIRS-AVDETLKING 209
gi 541046211 155 --------------FIVKGAs---RPFFSAQHP--LFTVDsr--vrKISTE---------QIITNKIRS-PINENLHAVV 203
gi 762142178 165 --------------FILEDL-ESkSTLFSTKSQtwTNVQNpg---iNLHVP---------SLTTAHIQSkTGVERLVMEA 217
gi 156386262 211 --------------FRFEDP-YAeKEVITFDGNkvLF-LPeyikgeEIGMN---------RIISHRIVS-DDNNNLTLSA 264
gi 390370932 165 --------------LHIIDPlTGnTILHTANDSg--IPSPtg--mkQLKTT---------QVITTKVTP-SIVDDLRVMS 216
gi 954376026 161 --------------FIVRER-NTlNKTFDASQP--ILHLQkn--ikKISTK---------LIKTKKIRA-PLDNALTLDV 211
gi 514680604 246 --------------LRVTPE-DSsTAHFVGDAEqtQFSSEalvienNITARp--------QVEATRIEA-NAGEPLVVTS 301
gi 312066980 167 --------------FTIKDA-F--RPYFSVQHP--LFRVDkr--ikKISTA---------QIVTDKIRS-PINDNLYVDV 215
gi 71991474  144 ----------------vLSP-KDgRTLFSARHP--TVTIDkr--ikKLAAE---------RIITNKIRS-AVDETLKING 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41018012  211 PTRsLKMEAPRGVQVSAAAGDFKATcrKELHLQ-STE-GEIFLNA---D-S----------------------------- 255
gi 308486998 210 EN--VVLRGNEQVRIDARNVNFEGMkrM-VFNI-SRD-GILHMRG---R------------------------------- 250
gi 541046211 204 EN--LSVRGNEGIKMEAKRFNVTAk--TSIGLRtSKD-GKLTFSA---K-K----------------------------- 245
gi 762142178 218 D-K-MYLTGFEGVVMTSEREYFHADlgRRLYIQ-SKD-GDINIEAt--N-H----------------------------- 261
gi 156386262 265 STS-MDISGHEGVNMDGKTLTFEANtdVNI-IS-SVS-NRMELSA---Q-K----------------------------- 307
gi 390370932 217 DQV-LTIQGNEGLTIGAKDIDMSGS---NIILN-ALD--TLSLEGgpdG-G----------------------------- 259
gi 954376026 212 EN--LSFRGNEGTLLSSRAMNIRs--tQSITLK-TGDrGVMNLTA---GqG----------------------------- 254
gi 514680604 302 DRS-L-----------------TATsfLDTTLS-STH-GHVHVRA---R-Gpgnnltfvntndivtaipflessfnaggd 357
gi 312066980 216 VN--LGLRGNEGIHLEAKRINLTAG--TGISLG-TTAdGLIMFST---K-K----------------------------- 257
gi 71991474  193 EN--VVLRGNEQVRIDARNVNFEGL--KRMVFN-ISRdGILHMRG-----R----------------------------- 233
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 41018012  256 -IRLG---NL----PIGSfssstssSNSRQTV---YELCVC--P--NGKLYLSPAGV 297
gi 308486998 251 -IRLGdgaSSl---PMST-------SPSLSASldgMRLCAC--AqfNHKLFIVPANK 294
gi 541046211 246 -IFIG---SNwlplPIST-------SPALTASidaMRVCICiaA--RPKLFVVAGNK 289
gi 762142178 262 -TFIN---KNi---PNSSq-------FSPVTNitvYKVCLCi-P--SGRLFIVepls 301
gi 156386262 308 -VALK---Pa---------------SNSIPSNtnnYKLCVCr-T--SSKLYAVDSPq 342
gi 390370932 260 -VYINt--TLl---PRKSt------T-RTGGAgmgLTLCVCg-G--TGRIFQVTAPp 300
gi 954376026 255 -LFLT---SAqr-lPLSD-------SPSFRANvlgRRLCSC--Ag-TGRLFTVAGNM 296
gi 514680604 358 gMFLN---LRqlrrPDAVs------S----GNltsFTLCNC--A--DNSIYLVQGNA 397
gi 312066980 258 -LYFG---NSlktlPLSS-------SPSLTASidaLRVCVCm-Ss-KPRLFVVAGNk 301
gi 71991474  234 -VRLG---DGaaslPMST-------SPSLSASldgMRLCACa-Qf-NHKLFIVPANK 277
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap