Conserved Protein Domain Family
Gasdermin

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pfam04598: Gasdermin (this model, PSSM-Id:309647 is obsolete and has been replaced by 398339)
Gasdermin family
The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein
Statistics
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PSSM-Id: 309647
Aligned: 14 rows
Threshold Bit Score: 456.854
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9D8T2   4 AFEKVVKNVIKEVSgsRGDLIPVDSLRNSTSFRPYCLLNRKFSSsRFWK-PRYSCVNLSIKDILEPSA-PEPEPECFGSF 81  house mouse
Q29S10   4 AFEKVVRSVVRELD--HKDLTPVDSLWSSTSFQPYTLLSRKPLSsRFWR-PRYKCVNLSIRDILEPDA-PEPALECGRTF 79  cattle
P57764   4 AFERVVRRVVQELDh-GGEFIPVTSLQSSTGFQPYCLVVRKPSSsWFWK-PRYKCVNLSIKDILEPDA-AEPDVQRGRSF 80  human
Q3TR54   4 SFDRASKDVVKKLQ--GRDLRPVECLSDATKFRLFHILQETPRS--GWE-TEDIPVGFTLLDLLEPNF-PVPEPEVSAPK 77  house mouse
Q99NB5   4 TFDWLSKDVVKKLQ--GRDLRPVKCLSDATKFCLFNILQETSSR-LALK-TEYIPVGFTLLHLLEPNI-PVPEPEVSAPI 78  house mouse
Q6J2R6   1 MFAKATKNLLSEIDs-EGFLIPVLCLNDSDGLSPQALVIKRNRY-WFWQqPKYKPTDFKLSDVLVGDP-INPVVVETEFL 77  zebrafish
Q9Z2D3   1 MFAKATRNFLKEVDa-GGDLISVSHLNDSDKLQLLSLVTKKKRY-WCWQrPKYQILSATLEDVLTEGHcLSPVVVESDFV 78  house mouse
O60443   1 MFAKATRNFLREVDa-DGDLIAVSNLNDSDKLQLLSLVTKKKRF-WCWQrPKYQFLSLTLGDVLIEDQfPSPVVVESDFV 78  human
Q96QA5   3 MFENVTRALARQLNp-RGDLTPLDSLIDFKRFHPFCLVLRKRKStLFWG-ARYVRTDYTLLDVLEPGS-SPSDPTDTGNF 79  human
Q32M21   3 MFEDVTRALARQLNp-RGDLTPLDSLIDFKRFHPFCLVLRKRKStLFWG-ARYVRTDYTLLDVLEPGS-SPSDPTLLGNF 79  house mouse
Q9D8T2  82 KVSDVVDGNIQGRVMLSGM-GEGKISGGAAV-SDSSSASMNVCILRVTQKTWETmqhERHLQQPENKILQQLRSRG-DDL 158 house mouse
Q29S10  80 QFHDAMDGQLQGSVKLAAP-GQGRLSGGAAV-SGSSSASMDLCTLRVTPNTWEAmhhERRLRQPEPKTLQQLRSRG-DDV 156 cattle
P57764  81 HFYDAMDGQIQGSVELAAP-GQAKIAGGAAV-SDSSSTSMNVYSLSVDPNTWQTllhERHLRQPEHKVLQQLRSRG-DNV 157 human
Q3TR54  78 PFIHVQSTDLEANLNVA------DIARGGVGyVGYGGYNIEVQSTSIPNPKLEIl-qNRKLLDKLPTFMKFCRMER-KNL 149 house mouse
Q99NB5  79 PLKHTISQKLKADLDVE------TIAGGEAGfVKSCGYDIEVQSKSIPNPKLESl-qNRKLLDQLPTFMKTCWKDG-KNL 150 house mouse
Q6J2R6  78 TYKGKVMDTKSGSAVAELGpGTINIGGSGSSkLQSSFGNLKKQELDLQKLLHDS---KSRVLDMQHSLIQQTRNAKtEVL 154 zebrafish
Q9Z2D3  79 KYESKCENHKSGAIGTVVGkVKLNVGGKGVVeSHSSFGTLRKQEVDVQQLIQDA---VKRTVNMDNLVLQQVLESRnEVL 155 house mouse
O60443  79 KYEGKFANHVSGTLETALGkVKLNLGGSSRVeSQSSFGTLRKQEVDLQQLIRDS---AERTINLRNPVLQQVLEGRnEVL 155 human
Q96QA5  80 GFKNMLDTRVEGDVDVP---KTVKVKGTA---GLSQNSTLEVQTLSVAPKALETv-qERKL-AADHPFLKEMQDQG-ENL 150 human
Q32M21  80 SFKNMLDVRVEGDVEVP---TMMKVKGTV---GLSQSSTLEVQMLSVAPTALENlhmERKL-SADHPFLKEMREYK-QNL 151 house mouse
Q9D8T2 159 FVVTEVLQTKEEVQITEVHSQEGSGQFTLPG-ALCLKGEGKGH------QSRKKMVTIPAGSILAFRVAQLLIGSK--WD 229 house mouse
Q29S10 157 FVVTEVLQTQKEVEVTRTHKQEGSGQFALPG-AFCLQGKGEGH------LSQKKTVTIPSGSTLAFRAAQLVIGSD--WD 227 cattle
P57764 158 YVVTEVLQTQKEVEVTRTHKREGSGRFSLPG-ATCLQGEGQGH------LSQKKTVTIPSGSTLAFRVAQLVIDSD--LD 228 human
Q3TR54 150 YVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQ-LFKVRGKAG--------RSEKYSIPIPKGSVLAYKKQQLVIENNtcVI 220 house mouse
Q99NB5 151 YVVTEAYEVTKDTVLEGTSNSKFAIKGIINQ-LVKVGGSGQWQ------TEKTDSIPIQKGSVLAYKKQQLVIEDNtcVI 223 house mouse
Q6J2R6 155 AVVKERIITTQPCTITEEVQEGGSCTGMFGF-NKTIKVSSNDKgkpsiaYDTDVSIDIPPKTTLAYSVIELDIAHTghYE 233 zebrafish
Q9Z2D3 156 CVLTQKIMTTQKCVISEHVQSEETCGGMVGIqTKTIQVSATEDgt--vtTDTNVVLEIPAATTIAYGIMELFVKQDgqFE 233 house mouse
O60443 156 CVLTQKITTMQKCVISEHMQVEEKCGGIVGIqTKTVQVSATEDgn--vtKDSNVVLEIPAATTIAYGVIELYVKLDgqFE 233 human
Q96QA5 151 YVVMEVVETVQEVTLERAGKAEACFSLPFFA-PLGLQGS----------INHKEAVTIPKGCVLAFRVRQLMVKGKdeWD 219 human
Q32M21 152 YVVMEVVKAKQEVTLKRASNAISKFSLNLP--SLGLQGS----------VNHKEAVTIPKGCVLAYRVRQLIIYGKdeWG 219 house mouse
Q9D8T2 230 ILLVsDEKQRTFEP---------SSGDRKAVGQRHHGLNVLAALCSIGKQlsllsdGIDEEELIEAADFQGLYAE---VK 297 house mouse
Q29S10 228 ILLFpDKKQRTFLSlq------aGRRPSSSADSHPHPCFSLASIRALSDYfhfqpdGSTEHWLATTDDYQGLRAE---VK 298 cattle
P57764 229 VLLFpDKKQRTFQPpa------tGHKRSTSEGAWPQLPSGLSMMRCLHNFl----tDGVPAEGAFTEDFQGLRAE---VE 295 human
Q3TR54 221 LPSA-TKKKMTFPDrplklydlpVTLRYQEEVIETGSWIDDi-------------dPIGTIEEPANLNFMCLQHE---VS 283 house mouse
Q99NB5 224 LTSAnTKKKMTFPMrfv---gmsGHLRYQDLVIETGSWINDi-------------dPIGTIKEPTHLDFMCLQNE---VS 284 house mouse
Q6J2R6 234 LCLL-PAVKGGFEI-------------------------------DGPVKv----kQAVTVSAAPGNPTHNMQKElvgLE 277 zebrafish
Q9Z2D3 234 FCLL-QGKHGGFEHer-----klDSVYLDPLAYREFAFLDMl--------------DGGQGISSQDGPLRVVKQAtlhLE 293 house mouse
O60443 234 FCLL-RGKQGGFENkk-----riDSVYLDPLVFREFAFIDMP--------------DAAHGISSQDGPLSVLKQAtllLE 293 human
Q96QA5 220 IPHIcNDNMQTFPP---------------------------GEKSGEEKVi----lIQASDVGDVHEGFRTLKEE---VQ 265 human
Q32M21 220 IPYIcTDNMPTFNP----------------------------L-CVLQRQg----sTVQMISGEMHEDFKTLKKE---VQ 263 house mouse
Q9D8T2 298 ACSSELESLEMELRQQILVNIGKILQDQPSMEALEASLGQGLCSGg---------QVEPLDGPAGCILECLVL------- 361 house mouse
Q29S10 299 AWAMGLEGLSKGLCGQLLGGLGQVLRDEPALQALEDSLEQGLCSG----------PVEPRDGPVGAILESLVL------- 361 cattle
P57764 296 TISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLG----------PVEPLDGPAGAVLECLVL------- 358 human
Q3TR54 284 EQTQLLAELSKDVQEVVFSSFLHMLSDRDVLYDLMKMLELN--------------QLGHMDGPGGKILDELRK------- 342 house mouse
Q99NB5 285 EQTRLLAELSKDVQEVVFSSFLHMLCDRDVLYDLMKMLELN--------------QLGHMDGPGGKILDELRK------- 343 house mouse
Q6J2R6 278 GQFKVLSKLPSSTRFSLFQQISLLLQNSAVISILGSTLEDLCGGTqp-------dPSTLAEVPELKVTLELIQksag--- 347 zebrafish
Q9Z2D3 294 RSFHPFAVLPAQQQRALFCVLQKILFDEELLRALEQVCDDVAGGLwssqavlameELTDSQQQDLTAFLQLVGyriqgeh 373 house mouse
O60443 294 RNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLsptv--avlgELKPRQQQDLVAFLQLVGcslqg-g 370 human
Q96QA5 266 RETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALE------------------GALDKGHEVTLEALPK------- 320 human
Q32M21 264 QETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQMLE------------------GALDKGHEVTLEALPK------- 318 house mouse
Q9D8T2 362 ---DSGELVPELAAPIFYLLGALAVLSETQQQLLAKALETTVLSKQLELVKHVLEQSTPwqeqssvSLPTVLLGDCWDEK 438 house mouse
Q29S10 362 ---PSGQLETELAGPVFYLLQALAVLSEAQHVLLAEVLEMGALSGTFWLVESLVEQSSPwqehravSLPPERLGDSWGSE 438 cattle
P57764 359 ---SSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPwqerstmSLPPGLLGNSWGEG 435 human
Q3TR54 343 ---DSSTPHDVLKDLNLYLLQALLVLSDTQLCLLAQSVKMGLLPHQVELVKSILQTNFKyssntpfTLQPQLLAPLQGEG 419 house mouse
Q99NB5 344 ---DSSLSWINLKDLILYLLQALMVLSDTQLCLLALSVEMRLLPHQVELVKSILQPNFKypwnipfTLQPQLLAPLQGEG 420 house mouse
Q6J2R6 348 kkpSGQHQKQSTLTATHLLISALDEMSKPALFLLKSCCSYTTLQALLHLVQNMALNEKS-------SLKDAALDVLADEV 420 zebrafish
Q9Z2D3 374 pgpQDEVSNQKLFATAYFLVSALAEMPDNATVFLGTCCKLHVISSLCCLLHALSDDSVC-------DFHNPTLAPLRDTE 446 house mouse
O60443 371 cpgPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVS-------DLEDPTLTPLKDTE 443 human
Q96QA5 321 ----DVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLldkegvfPLQPELLSSLGDEE 396 human
Q32M21 319 ----DVLLLKDAMDAILYFLGALTELSEEQLKILVKSLENKVLPVQLKLVESILEQNFLqdkedvfPLRPDLLSSLGEED 394 house mouse
Q9D8T2 439 --NPTWVLLEECGLRLQ--VESPQV 459 house mouse
Q29S10 439 --APGWALLEACGLEPQ--VGTPQV 459 cattle
P57764 436 --APAWVLLDECGLELG--EDTPHV 456 human
Q3TR54 420 l-AITYELLEECGLKME--LNNPRS 441 house mouse
Q99NB5 421 l-AITYELLEECGLKME--LNNPRS 442 house mouse
Q6J2R6 421 vfKNITSLFNSCNVMLLk-DDNSLI 444 zebrafish
Q9Z2D3 447 rfGIVQRLFASADIALErmQFSAKA 471 house mouse
O60443 444 rfGIVQRLFASADISLErlKSSVKA 468 human
Q96QA5 397 l-TLTEALVGLSGLEVQ--RSGPQY 418 human
Q32M21 395 q-ILTEALVGLSGLEVQ--RSGPQY 416 house mouse
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