Conserved Protein Domain Family
Mob1_phocein

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pfam03637: Mob1_phocein 
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Mob1/phocein family
Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.
Statistics
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PSSM-Id: 308952
View PSSM: pfam03637
Aligned: 169 rows
Threshold Bit Score: 131.494
Threshold Setting Gi: 0
Created: 18-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam03637 is a member of the superfamily cl04190.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4J1V_A           7 G-NLRQAVMLPE-GEDLNEWIAVNTVDFFNQINMLYGT-IT-EFCTEASCPVMSAGpRYEyhwad-gtnikKPikCSAPK 81
88_pfamImport    7 FnNVDEILSAPE-GQDEVVWKYEHLRQFCMELNG-LAVcLQeQ-CTPKTCPQMTATeQWIflcaa--hktpKE--CPAVD 79
1_pfamImport     7 FrNIEAILTEPQ-GQDLGVWKYEHLRQFCMELNG-LAVlLQyH-CTPETCAQMTATeQWIflcaa--hktpKE--CPAIN 79
63_pfamImport    7 PsDVDTILKVPP-GQEEGVWKYEHVRQFCMQLNG-LTLlLQdE-CKPDVCMQMTATeQWIflcaa--hknpKE--CSAID 79
103_pfamImport   7 YkDVEAILDPPP-VQDEASWKYEHLRQFCNELNS-LTVcLLeE-CDPLVCKQMTATeQWIflcaa--hrqpKE--CSALD 79
gi 30923220     51 PaDVATILTPPL-DQDEGVWKYEHLRQFCIELNG-LALlLQrE-CIPETCQQMTATeQWIflcaa--hknpNE--CPAID 123
2_pfamImport     7 PhAVARIIKLPSpHVQREVWIYEQLRRLAHDLGHPLVSaLQaD-CNRAKCPEMKAg-EWLylcaahataneNE--CCAID 82
142_pfamImport   4 rsdCARLAAPPE-GIEETLWVYELTRRLTRDLNI-LIItLHsAPCNNSTCPEMRAs-EWQylcav--hptpQS--CSAID 76
147_pfamImport   7 ReNIDALVELPA-GQDKETWQYEHLRQLCLELNY-LVIqLEaE-CTSQTCPEMKAd-DWQylcaa--hqapLN--CCAID 78
136_pfamImport   7 YsDVQRIIELPE-NVDDEVWQYEHLRQVCLELSL-LVVaLEtD-CTKQHCPEMKAd-GWLylcaa--hpstQS--CPAID 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4J1V_A          82 YIDYLMTWVQDQLDDETLFPSKIgVPfPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQ------EEAHLNTSFkhFI 155
88_pfamImport   80 YTRHTLDGAACLLNSSKYFPSRV-SI-KVTSVNRLDSVCRRVYRIFSHAYYHHREIFDSFE------ESTALCRR---FT 148
1_pfamImport    80 YTRHTLDGAACLLNSSKYFPSRV-TI-RESSLAKLSSVCRRVYRIFSHAYYHHRSLFDQFE------EKTVLCQR---FT 148
63_pfamImport   80 YTRHTLDGAAALLNSNKYFPSRI-SI-KESSIAKIGSVCRRIYRIFSHAYFHHPELFENFE------TETHLCRR---FT 148
103_pfamImport  80 YTLHTLHGAASLLNSNKHFPSRV-SI-KENSAQKLSSVARRIYRIFSHAYCHHRTLFNDFE------EKTYLCKR---FT 148
gi 30923220    124 YTRHTLDGAATLLNSNKYFPSRV-NI-KEISISKLGSVARRVYRIFSHAFFHHRKLFDEFE------NETHLCKR---FT 192
2_pfamImport    83 YIVHTLDGATALLNSARYFPSRL-QI-PASSIKHFTSIARRLYRILAHAWFHHRELFEECE------METSLYAR---FL 151
142_pfamImport  77 YSTHTLDQAATMLTSTKYFPSRL-SI-SQGSFKHLVSIFRRLYRIFAHAWFAHREAFWEAE------RETRGVFRL--FM 146
147_pfamImport  79 YIVHTLDGATTLLNSHKYFPSRI-SI-PETSLKHYQSIARRLYRIFAHTWFHHREIFEAFE------NENMLYAR---FL 147
136_pfamImport  79 YIIHTLDGATILLNNSKYFPSRI-SV-PEPSLKHFQSIARRLYRIFAHAYFHHREIYESFEasleflNETYLYAR---FL 153
                          170
                   ....*....|....*...
4J1V_A         156 FFVQEFNLIDRRELA-PL 172
88_pfamImport  149 TFVLKYNLMSKDNLIvPI 166
1_pfamImport   149 VFVLKYNLMNKQNLLvPM 166
63_pfamImport  149 VFVKKYNLMANEHLIvPI 166
103_pfamImport 149 RYVIKYDLMTTDNLIvPL 166
gi 30923220    193 TYVSKYNLMQQEHLIvPI 210
2_pfamImport   152 ALTDEFGLIAEDLLViPR 169
142_pfamImport 147 AVAERYRLVPREGMMlPR 164
147_pfamImport 148 KLSDRYELIAKNLLIiPY 165
136_pfamImport 154 LLSQTYGLIPPSLVS--- 168
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