Conserved Protein Domain Family
DAD
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pfam02109: DAD (this model, PSSM-Id:307979 is obsolete and has been replaced by 460448)
DAD family
Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.
Links
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Statistics
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PSSM-Id: 307979
Aligned: 118 rows
Threshold Bit Score: 85.6407
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7Q4M9         5 TEVLYKFYDEYAHKTPKKLKIVDAYLLYILLTGITQFVYCCLV-G-TFPFNSFLAGFISTVSCFVLGVCLRLQSNpqNKE 82  Anopheles gambi...
Q4YDB3         2 NEMINNFYNKYMNITLKKIKFMDINIIFNLFNIILLSIYAFTF-S-LFKEKIANATIFTAIGNLTLLIALRVQIT--NKT 77  Plasmodium berghei
Q5CRL9        47 LDVFQEMKQAYFSKVPENIQILDSFILFMALISIIQIIYCLLIrT-TYPIDSLIGGVFCTTGTALLVSALRIQLTcp--s 123 Cryptosporidium...
A0EFY2        13 LGIAASFWQQYSTKTPQKLKIMDAFSLYCFILVIIQLFYCALV-G-DFPRNSFLSGIFAAAGAMIINICLRKQLNpeTK- 89  Paramecium tetr...
XP_002766749   7 rvMLEEGWEKYNGMTPQKIKILDLFIVFLAYLSVVQFAYMWVV-G-TFPYNSFLSGLWATMGTAVLTCCYRIQLTs-GQD 83  Perkinsus marin...
XP_012899003   4 yQVCKDLAERYKKETTLQVKYLDVFISFAAATAFLQAVYCFIV-G-TYPFNSFLSGFIISLGTCVLSICFRMGIT---SK 78  Blastocystis ho...
XP_653360     18 eSFIKVLLTSYSKETPSRLKMIDCFLIYQLITAALVLVYGFFF-C-HNPLNAFLAALFSCAGMFVFTMSLRLHe------ 89  Entamoeba histo...
XP_002139231  24 TEVFTEIMTSYLKVVPKHIQIIDCFISYLAIITITQLIYCILI-GmAYPLNSFIAGIFTSGGTALLVSALRIQLIa--pE 100 Cryptosporidium...
XP_001327154   7 SGILAELKEVYGKQ-KSHFRGLDIFALFGIMVALIQLVYSGLT-H-GYPFCSMVSAVCMSLGFTVLVISLRLHLTpeIES 83  Trichomonas vag...
XP_012762343   2 NKILSTFYENY-RNTPRNIKFVDIYILITLVNILLLYMYGYFS-C-SFDEKISVAAIFTALGNLTFSVALREQIS--NKS 76  Plasmodium reic...

Q7Q4M9        83 qFLGISPERGFADFVFAHIILHLVVVNFI 111 Anopheles gambiae str. PEST
Q4YDB3        78 -LFNLKQEKIIFDFVICSLILYIGLFSYI 105 Plasmodium berghei
Q5CRL9       124 yFGDVSPKTAFTDFVICCIVF------FI 146 Cryptosporidium parvum
A0EFY2        90 -YMEISNERAFWEYLAAMVVLFLTVINFL 117 Paramecium tetraurelia
XP_002766749  84 tFKEVGPERAYADYLVCAGVLFFSCVNFL 112 Perkinsus marinus ATCC 50983
XP_012899003  79 eFETISNNRVFAEYCFCMLLLFLVVCNYL 107 Blastocystis hominis
XP_653360     90 -SEEGSSKKYFVEYVFCVILLQLSVANFL 117 Entamoeba histolytica HM-1:IMSS
XP_002139231 101 lFDNISPKTAIFDFLICSFVFFIGCASLL 129 Cryptosporidium muris RN66
XP_001327154  84 ---SISNYRAFAEYIVALSLLFLFGWNFM 109 Trichomonas vaginalis G3
XP_012762343  77 lF-NIKREKIIFDFVLCSLVLYIGVFSYM 104 Plasmodium reichenowi
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