4P63


Conserved Protein Domain Family
DS

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pfam01916: DS (this model, PSSM-Id:307847 is obsolete and has been replaced by 460382)
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Deoxyhypusine synthase
Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation.
Statistics
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PSSM-Id: 307847
Aligned: 243 rows
Threshold Bit Score: 336.664
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4P63_A          32 EVVSY-YYRI-G-FQATHLGRAIEIWRKVEEkrergEEIRVFLGYTSNIISSGLREIIAWLVKEKKVDVIVTTAGGVEED 108 Pyrococcus ho...
166_pfamImport   1 DMLQA-MGRAgG-FTAQKLADATDIAEKMvk----kEGCLKILSFPACIMATGTRGVIVDMVKNHMVDLIITTCGCLDHD 74 
Q74MF0          17 ELIKQ-FSSIgG-FQAQELYRGYEILKEMf-----dNAEYKILSFPADIIATGIRGIIKELIKRKMFDLVITTCGTLDHD 89  Nanoarchaeum ...
30_pfamImport    1 ----E-LSQSgG-FESVNLSTGVDILSEMis----dKQCLKFISFVGAVVSTGLRGILKDMLKNKWFDVAITTCGALDHD 70 
144_pfamImport   1 ------MTRSgG-FESRNLADGVDILRRMid----dKSCTKFMSFVGALMSTGARGIIRDMVRNKMCDVIITTCGALDHD 69 
WP_012939763    16 ELIKE-LYKS-GgFTAKDLAVAVDIFEEMIKd----EECTVFLSFPACIIATGTRGVIKELVKRRLVDVIVTTCGTLDHD 89  Archaeoglobus...
WP_008085536    22 ELMDElYSSG-G-FVAKHLAVAEKILLKMFKe----ENTT-FLSFPACIIATGTRGVIKEIVRRKLVDVIITTCGMLDHD 94  Aciduliprofun...
AEA47349        23 ELVEQ-FGRA-GgFTAKKVAEAMHVLEEMVK-----SDATVFLSFPAAIVATGTRGVIKELVKRKLVDVIITTCGTLDHD 95  Archaeoglobus...
WP_020448597    20 DLISQ-MSNC-GgFTAKKLSDAVDITERMLKk----KDCTVFLSFPACIMATGTRGVIIELVKRGLVDVIITTCGTLDHD 93  Candidatus Me...
EQB66656        25 sdfvsqcnasgG-FTSSKIAVAHSIMEKIVKe----ENTT-FLSFPADIISTGTRGVIIDMIKKGLVDVIITTTGTIDHD 98  Thermoplasmat...
4P63_A         109 FIKSLKP-FILGDWEVDDAELRKKGVNRIGNIFVPNDRY-IEFEKYMIPFFERVL-K-IEEKLSrpltASEFIYEMGRYM 184 Pyrococcus ho...
166_pfamImport  75 LSRLY-AaYYKGDFMMDDALLRENDVSRLGNVLVPDDCYgYVLEDNLLPMFDEIF-A-ETQSMS----THEIIDKVGEKL 147
Q74MF0          90 LARLE-KdYYLGYFEADDIELREKNIFRLGNIFIPEENYgLAIENILKKALPYIY-N-KKKELS----TYEFVWLLGEYL 162 Nanoarchaeum ...
30_pfamImport   71 IARHF-ShYKEGSFTMDDNELADQDIHRLGNVLVPMDSYgPLIEEKMQTFLEEEY-QnGVKEMT----TAEICKMIGKHL 144
144_pfamImport  70 IARAY-DkYYAGDFRMDDGMLLDKDIHRLGNVLVPMGNYgPLIEEKIQKCLADMY-KeGKRSVS----TYEITDYIGSTL 143
WP_012939763    90 LARIWKd-YYHGSFMLDDVELYKKGIHRIGNVLTPKESYgLILEEKLQPIFEDIYnE-GKRRIS----TRELIWEVGKRI 163 Archaeoglobus...
WP_008085536    95 IARSFKn-YYHGSFLMDDTALHREGVNRLGNVLVPNESYgVVMENFMMPILEELY-K-EKKEWG----GRELIDEFAKRM 167 Aciduliprofun...
AEA47349        96 LARIW-RdYYHGSFMLDDAELHRMGINRIGNVLAPNESYgLILEEKLLPIIEDIY-S-SKKRLS----TRELVWEIGKRI 168 Archaeoglobus...
WP_020448597    94 LARTWKk-YYHGEFIMDDAKLYDEGINRLGNVLVPNSSYgLILEKKMQPMLKKIL-K-DRDSIS----TRELIDQVGAMV 166 Candidatus Me...
EQB66656        99 IARSFSd-YFCGSFEYDDIKLKDMGINRLGSVFVPDESYgSLIEEFMMKQLDTLY-K-EKKTWS----PSEILARIGRNM 171 Thermoplasmat...
4P63_A         185 ----D----EklgkekE----KSVIYWAYKNNIPIFCPAITDGSIGDmLYFFKEErRDSrLIIDIANDIVKLNNLAITAK 252 Pyrococcus ho...
166_pfamImport 148 ----AdvkgH------E----DSLLYWAHVNNVPIVVPGITDGSFGCqLWMYYQ--THRkLRIDLFADEQMLSEMTNDAK 211
Q74MF0         163 ----EnhpkK------E----ESIIYWAYKNRIPIIIPGITDGAVGTqILLFRQ--EHRdFNVNVWLDEEFLLNQFFGDK 226 Nanoarchaeum ...
30_pfamImport  145 ---------G------E----DSFLYWAYKNHISVVVPGIMDGAVGSqIWLFTQ--KHNdFKLNMAGDADLLSGYIFKAE 203
144_pfamImport 144 ---------D------K----SSFLYWAHKNRIPVIVPGIVDGAVGSqVWFFYQ--QHKdFKVDILKDQSKLSDIVFEAK 202
WP_012939763   164 ----E----G------EenadSSIVYWCYKNKIPVFVPGITDGAFGSqLWLFYQ--THKdFIVDVLKDEDELSEIIFNAK 227 Archaeoglobus...
WP_008085536   168 ----N----N------E----DSILYWAHKNKIPIYVPGITDGSFGSqLWSF--ReMHPdFRVDVLKDEHELADIIFDAK 227 Aciduliprofun...
AEA47349       169 egepD----A------E----DSIVYWSYKNRIPVFIPGITDGAVGSqLWIFYQ--QHKdFVIDVLADESELSDIVFESE 232 Archaeoglobus...
WP_020448597   167 ----N----D------E----SSLLYWCHKNNVPIFVPGITDGSFGSqVWMYWQ--EHRnLHMDLFQDEQDLMDMVFDAK 226 Candidatus Me...
EQB66656       172 ----D----H------P----DSILSAAAEKNVPIFIPGIPDGSVGSqFWSFYE--THRdFNLDILMDQHLISDIVFTSD 231 Thermoplasmat...
4P63_A         253 ETASIILGGSLPKHAIINANLFRGGTDYAIYISTAVPWDGSLSGAPPREGVSWGKIKAKADYVEVWGDATLIFPILV 329 Pyrococcus horik...
166_pfamImport 212 YTGAIIIGGGISKHHVIWWNQFRGGLDYCIYLTTAEEYDGSLSGARIREAVSWGKVKANAKKMTVEGDATITLPLIY 288
Q74MF0         227 NIGALMLGGGISKHHTIWWAQFSNGLKYAVYVTSAVELDGSLSGARTREAISWGKIDKKAKHVTIWGDVTIILPLLV 303 Nanoarchaeum equ...
30_pfamImport  204 KSGAFMIGGGISKHHTLWWNQYREGLDYAFYITTAQEFDGSLSGALVREAISWGKVTQKAKQSTLHAEVTTILPFIY 280
144_pfamImport 203 RSGAFMIGGGISKHHTLWWNQFRGGLDYAVYITTAPEWDGSLSGALVAEAISWGKVTAKARQVTIHGEATTLLPFIY 279
WP_012939763   228 RSGALIVGGGISKHHTIWWNQFKDGLDYVVYITTAVEWDGSLSGARVREAISWGKVSESAKSVNVYGDATVLLPLIV 304 Archaeoglobus pr...
WP_008085536   228 KTGALMIGGGISKHHTIWWNQFRDGLDYAVYITTAVEWDGSLSGARVREAVSWGKVREDAKYVTVEGDATVLLPLLI 304 Aciduliprofundum...
AEA47349       233 RTGALIVGGGISKHHTIWWNQFKGGLDYVVYVTTAVEWDGSLSGARPREAISWGKIKEGAKQVTVEGDATIILPLLV 309 Archaeoglobus ve...
WP_020448597   227 ESGAIMIGGGISKHHTIWWNQFRGGLDHAVYLTTAEEYDGSLSGARVREAVSWGKVKAAADYMTVEGDATITLPIIV 303 Candidatus Metha...
EQB66656       232 RAGAIMIGGGISKHHTIWWNQFRGGLDYAIYITTAQEYDGSLSGAKLEEAISWKKVKPDAEFVNVYGDATVLLPIIV 308 Thermoplasmatale...
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