Conserved Protein Domain Family
Caveolin
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pfam01146: Caveolin (this model, PSSM-Id:307342 is obsolete and has been replaced by 460081)
Caveolin
All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localization. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.
Links
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Statistics
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PSSM-Id: 307342
Aligned: 35 rows
Threshold Bit Score: 165.466
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6YLH7        17 HTKEIDLINRDPKQINEDVvKVDFEDVIAEPDGTHSMDGVWKASYTTFTVSKYWCYRVLSAVFGIPVALLWGFCFACISF 96  zebrafish
Q94051        96 IAIGVDLVNRDANSMNNHV-QLNFEDIFGEADSQHSWDCVWRLNHTVFTAVRLFIYRLVS-LLALPFTIIFAIFFGLLAS 173 Caenorhabditis ...
XP_002121873 103 kpdTTDYVNRDPRNLQESV-KVNFADIIAEPSGAHSFNTVWGTSYKVYSVTKYWVYRIMTLVFGVPCALIWGVYFACLAF 181 vase tunicate
KRX63267      99 MTIGINMLDRDEKQLNEHI-KLNFEDILAEPDGYHSWDWVWRGTYHTFNTLRRFIYRFLALLFAVPCAIVWAMLFALLTS 177 Trichinella sp. T9
KKA78793     139 MTIGIDMQMRDEKQINNHV-NIQFDDVFAEPETFHSVDCIWRINHRIFESTRTFFYKVFG-ILSIPIVFIFAILFAFASA 216 Pristionchus pa...
EGT60057      95 QRMGINFVDRDRNNLATNL-DFSFENVFGENKAQHSWEWSYRINHYVYSAFKEIFYKLFQ-WCVLPFTVFFAIFVALFVT 172 Caenorhabditis ...
XP_002632823 100 IAIGMDFVNRDHNGLNNHV-QHNFDDIFGEADSQHTWEFMWRLNASVFNWVRLFVYRFFT-ILALPFTLLFAIFFGFFAA 177 Caenorhabditis ...
ETE68531     287 HTKEIDLVNRDPKHLNDEVvKIDFEDVIAEPAGTHSFDGIWKASFTTFTVTKYWFYRLLSAIFGIPMALIWGIYFAILSF 366 king cobra
ERG82121      89 MTVGINMLDRDEKGLNNHV-MMDFGDVFAEPDSSHSWQWTWRIAHRIYSFISGFVYKLLAAIFAIPIAILFGILFALFSA 167 pig roundworm
XP_007500210  36 LKKEIDLVNRDPRHINEDVvKVDFEDVIAEPDGTYSFDGVWKVSYTTYTVSKYWCYRLISTLLGCPLALFWGCIFALISF 115 gray short-tail...

Q6YLH7        97 CHIWAVMPCIKSYLIETQCLSRIYSLCIHTFCDPLFEALGKIFSSVRVALR 147 zebrafish
Q94051       174 INVFIIVPLGKLLSIPGTLLAKLWNWLIHAIFDPIASAVGLIFSNFNIRKy 224 Caenorhabditis elegans
XP_002121873 182 LSIWWIMPCIRCLGIKINFIGKIWSLTVRTILDPVFESIGLLLSRIRIVMS 232 vase tunicate
KRX63267     178 INVWILTPLAIAISIPAVWLAKTWNFIIRSLLDPFFKSCGLMRAAHSespt 228 Trichinella sp. T9
KKA78793     217 VNNFLVMPLAALFTIPLTGIAKTWTFLVSNIFDPVANSIGLCFSKINVRKy 267 Pristionchus pacificus
EGT60057     173 LYSWILLPLGKLLIIPGTVVAAVWSWLIHAIFDPIFSSLGLLFSNFNIRKy 223 Caenorhabditis brenneri
XP_002632823 178 VNVFVIVPFGKLISIPGNLLAKLWNWLVHAVFDPVASAVGLIFSNFNIRKy 228 Caenorhabditis briggsae
ETE68531     367 FHIWAVVPCIRSYLIEIQCIGRVYSIFIHTFCDPFYEAVGKMLSFIRVTVR 417 king cobra
ERG82121     168 ISIFLCTPIGRLLGIPANGIAKAWDFFVHRFLDPIFSSLGLCCGAFASRKt 218 pig roundworm
XP_007500210 116 FHIWTVVPCIKSCLIEMQCISRVFSLFIHTFCHPVFNAMGQMCSSIKLVFR 166 gray short-tailed opossum
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