Conserved Protein Domain Family

pfam00379: Chitin_bind_4 (this model, PSSM-Id:306811 is obsolete and has been replaced by 425649)
Insect cuticle protein
Many insect cuticular proteins include a 35-36 amino acid motif known as the R&R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD).
PSSM-Id: 306811
Aligned: 107 rows
Threshold Bit Score: 37.6207
Threshold Setting Gi: 122117335
Created: 12-Jul-2016
Updated: 4-Aug-2016
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q17BL9        43 YSYESGNGIKV-----EDQGElkvvevpkedgtGTEQAQVSVQkGSYSYNAPDGTPITLQW-TA-DEN-GF 105 yellow fever mosquito
Q28XX8        85 FEYAVQDPETA-----NDYAH------------KASSDGDVVT-GEYRVQMPDGRTQVVRY-TAdWKT-GY 135 Drosophila pseudoobscura
Q5TUX2        66 YKYEVKDP---------EKQLffd-------knEAGDTAGKVT-GRYSVWLPDGRLMTIKY-IV-DKEgGF 117 Anopheles gambiae str. PEST
Q16XV2       159 FTYEVDDE-DRdlsfgHEEMR----------------DGDYTT-GKYNVLLPDGRRQIVEY-EA-DHK-GY 208 yellow fever mosquito
Q16X58        39 FRYYIDHP-QTgvsldHWENR----------------RGDYVH-GGYGVLEPGGYVRTVHYeVE-GNS-GF 89  yellow fever mosquito
Q9W079        54 HQYHISDVASRvh-ilHREQR----------------HGDYVS-GSYSHLEPSGHIRSVHYeVR-GANrGF 105 fruit fly
Q16IY2        54 YSYVVRDD-KSgdrksQHESR----------------QGDQVR-GQYRMMESDGTERIVDY-SAdDRN-GF 104 yellow fever mosquito
XP_001238132  90 FSYSVHDP-VTgdqksQEESR----------------RNGHVR-GQYSWVDADGIRQIVNY-RAdDRT-GF 140 Anopheles gambiae str. PEST
ETN66893     110 FEYNVQDFASGnd-fgHMESR----------------DGDRTV-GRYYVLLPDGRKQVVNY-EA-DQN-GY 159 Anopheles darlingi
XP_002083599  94 FSYGVTDH-HTgdskqQEET----------------LVNGVVH-GSYSLAEPDGTIRKVTY-TAdKVN-GF 144 Drosophila simulans
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