Conserved Protein Domain Family
FERM_C

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cd00836: FERM_C (this model, PSSM-Id:29846 is obsolete and has been replaced by 275389)
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The FERM_C domain is the third structural domain within the FERM domain. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM_C domain is also found in protein tyrosine phosphatases (PTPs) , the tryosine kinases FAKand JAK, in addition to other proteins involved in signaling. This domain is structuraly similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.
Statistics
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PSSM-Id: 29846
View PSSM: cd00836
Aligned: 37 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 4-Feb-2003
Updated: 10-Jan-2006
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site
Evidence:
  • Structure:1J19_A; Radxin Ferm domain bound to ICAM-2 cytoplasmic peptide
    View structure with Cn3D
  • Comment:binds to peptides in a similar mechanism to PTB domains.
  • Structure:1MK7; Talin FERM domain bound to beta-integrin
    View structure with Cn3D
  • Structure:1EFI_A; Moesin FERM bound to C-terminal tail
    View structure with Cn3D
  • Comment:This interaction masks the binding site of both the FERM and actin binding tail

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          # ## ###       #              
1EF1_A       197 XYGVNYFSIKNKK-----GSELWLGVDALGLNIYEqndrltpkIGFPWSEIRNISFNDKKFVIKPIdk------------ 259
1J19_A       200 MYGVNYFEIKNKK-----GTELWLGVDALGLNIYEhddkltpkIGFPWSEIRNISFNDKKFVIKPIdk------------ 262
1MK7_B        99 TYGVSFFLVKEKMkgknkLVPRLLGITKECVMRVDektk-eviQEWSLTNIKRWAASPKSFTLDFGdy------------ 165
gi 21292473  318 TYGVTFFLVKEKMtgknkLVPRLLGVTKDSVLRLDettk-eilKSWPLTTVRRWGASPNTFTLDFGdy------------ 384
gi 954750    335 TYGVTFFVVKEKLpgknkLVPRLLGVNKESVMRVDensk-qilKEWPLEQVRRWVPSAKCFSLDFGdy------------ 401
gi 135290    307 TYGVSFFLVKEKMkgknkLVPRLLGITKECVMRVDektk-eviQEWSLTNIKRWAASPKSFTLDFGdy------------ 373
gi 14916850  227 TYGVHYYAVKDKQ-----GIPWWLGLSYKGIFQYDyhdkvkprKIFQWRQLENLYFREKKFSVEVHdprrasvtrrtfgh 301
gi 31234772  218 GYGQETFTAKNDT-----GLEVMLGISVSGIIVASdt-----nKFYPWRDITNVVNHKRAFNIECTvp------------ 275
gi 12804015  184 NYGIEWHSVRDSE-----GQKLLIGVGPEGISICKddf--spiNRIAYPVVQMATQSGKNVYLTVTkes----------- 245
gi 19920808  224 GYGEERFAAKDTL-----GNDLLLGLAINGMVVNAdn----grQYFPWKEFHTVTIDKRTIKIEQNkldg---------- 284
                         90       100       110
                 ....*....|....*....|....*....|..
Feature 1                            #   #  #   #
1EF1_A       260 --kaPDFVFYAprlriNKRILALCXGNHELYX 289
1J19_A       263 --kaPDFVFYAprlriNKRILALCMGNHELYM 292
1MK7_B       166 --qdGYYSVQTt---eGEQIAQLIAGYIDIIL 192
gi 21292473  385 --adSYYSVQTt---eAEQIVQLIAGYIDIIL 411
gi 954750    402 --qdGYYSVQTt---dGEKIAQLIQGYVDIIL 428
gi 135290    374 --qdGYYSVQTt---eGEQIAQLIAGYIDIIL 400
gi 14916850  302 sgiaVHTWYACpa--lIKSIWAMAISQHQFYL 331
gi 31234772  276 ---rESAGFTVtdvatGRYIWKLCALQHRFYV 304
gi 12804015  246 -gnsIVLLFKMistraASGLYRAITETHAFYR 276
gi 19920808  285 -ggsIVGSFIFseadtARYFWKLTISQHKFFK 315

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