Conserved Protein Domain Family
Bcl-2_like

?
cl02575: Bcl-2_like Superfamily 
Click on image for an interactive view with Cn3D
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane segment. Some homologous proteins, which are not included in this model, may miss either the BH4 (Bax, Bak) or the BH2 (Bcl-X(S)) region, and some appear to only share the BH3 region (Bik, Bim, Bad, Bid, Egl-1). This family is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases. Bcl-2 and the closely related Bcl-X(L) are anti-apoptotic key regulators of programmed cell death. They are assumed to function via heterodimeric protein-protein interactions, binding pro-apoptotic proteins such as Bad (BCL2-antagonist of cell death), Bid, and Bim, by specifically interacting with their BH3 regions. Interfering with this heterodimeric interaction via small-molecule inhibitors may prove effective in targeting various cancers. This family also includes the Caenorhabditis elegans Bcl-2 homolog CED-9, which binds to CED-4, the C. Elegans homolog of mammalian Apaf-1. Apaf-1, however, does not seem to be inhibited by Bcl-2 directly.
Links
?
Taxonomy: root
PubMed: 19 links
Book:
Protein: Related Protein
Related Structure
Statistics
?
Accession: cl02575
PSSM Id: 295377
Name: Bcl-2_like
Created: 8-Feb-2008
Updated: 2-Feb-2016
Superfamily
Click to see Superfamily Help
Curated CD Hierarchy
Click to see Curated CD Hierarchy Help
cd06845:Bcl-2_like
CD Hierarchy
Imported CD
Click to see Imported CD Help
   
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap