1QLV,1TED,1CGZ,1EE0,1CML


Conserved Protein Domain Family
CHS_like

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cd00831: CHS_like (this model, PSSM-Id:29418 is obsolete and has been replaced by 238427)
Click on image for an interactive view with Cn3D
Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy, after the starter molecule is loaded onto the active site cysteine, a carboxylative condensation reation extends the polyketide chain. Plant-specific PKS are dimeric iterative PKSs, using coenzyme A esters to deliver substrate to the active site, but they differ in the choice of starter molecule and the number of condensation reactions.
Statistics
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PSSM-Id: 29418
View PSSM: cd00831
Aligned: 67 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 6-Mar-2002
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EEO; Gerbera 2-pyrone synthase with bound acetoacetyl-Coa
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1QLV_A     21 LATILAIGTATPPNCVAQADYADYYFRVTkseh--------mvdLKEKFKRICEk----------TAIKKRYLALT---- 78  Gerbera hybrid cul...
1EE0_A     21 LATILAIGTATPPNCVAQADYADYYFRVTkseh--------mvdLKEKFKRICEk----------TAIKKRYLALT---- 78  Gerbera hybrid cul...
NP_921952   3 VATMLTLTLLAYSAAMLARLLVARSRRRRcylldyv--cykatdDRKLPTDLCGeiiq---rnklLGLEEYKFLLKvivn 77  Japanese rice
XP_470781   4 TPLLAVVLFLPPPLAVAHMAWTAASRRRGmrcylldyvcykpadDLTLTTELACaivqr--nerlGIPEFRFLVRLisrt 81  Japanese rice
BAB10089   26 VSVFEIFAGLLVVHLIYQRIRTRVKVYLLd-------------fTCYRAPDSNRvp-------msTLIETIYLDDKldq- 84  thale cress
NP_918065  46 HAATAAVLAAGVARLVRARRARGVYLVEY---------------GCFRPRPCYRap--------fATCLEHAHLMPyl-- 100 Japanese rice
XP_450594  28 LVPLVASALLFVVAVVLRRRRRPVYLLNYschl--------pdvDRKVNLEVCEy----------FGQRCRHYSDDt--- 86  Japanese rice
XP_468364  14 HAAAWVAWQAAARRRRATCYLLDYACHKPsddrkvt--telagaIIERNKRLGLpeyrfllkvivNSGIGEHTYSPrn-- 89  Japanese rice
XP_470771  14 HAVAYLAWTAAARRRQSRCYLLDYVCHKPsddrkvs--teaagaVIERSKRLSLp---------eYRFLLRVIVRSgi-- 80  Japanese rice
AAM91194   13 SYLIFKIWKRIDSKRDQNCYILDYQCHKPsddrmvntqfsgdiiLRNKHLRLNE-----------YKFLLKAIVSSgi-- 79  thale cress
Feature 1                                                                                     
1QLV_A     79 ----EDYLQenptmc----------efmapsLNARQDLVVTGVPMLGKEAAVKAIDEWG--------LPKSKITHLIFCT 136 Gerbera hybrid cul...
1EE0_A     79 ----EDYLQenptmc----------efmapsLNARQDLVVTGVPMLGKEAAVKAIDEWG--------LPKSKITHLIFCT 136 Gerbera hybrid cul...
NP_921952  78 sgigEETYGprniigg--------gdarpdrLAEGMEEMDETFHAVLDELFARSSAAGGg------gVRPADVDLLVVNV 143 Japanese rice
XP_470781  82 -glgDRTYAprnll-------------dgreELAAQRDSVDEMDACFDGAVPELLARTG--------LRARDVDVLVVNV 139 Japanese rice
BAB10089   85 --esIDFQArilerswlsnqtsiprslmeipLKKSLSSVKIETMTTIFTSVEDLLRKNK--------LSPRSIDILITNC 154 thale cress
NP_918065 101 --vdEESVAfairllers-----glgdetcvPDAYHYMPPDRSLRASRDESELVIFSAVddvfarsaLTPADIDVLIVNC 173 Japanese rice
XP_450594  87 ----ADFMRliyrksglgqetyappfifsgeFQKTQAFAVQEAEEGLFATVAHLLAKSD--------VRPRDVGFVVVAC 154 Japanese rice
XP_468364  90 ---vLDARE----------------------DCPTLRDALDEMDDFFDDAVAAVLARAA--------VSPRDVDLLVINV 136 Japanese rice
XP_470771  81 ---gEETYAprnvl-------------dgreGEPTHGDSLGEMEDFFGDSIAELFARTG--------FGPRDVDVLVVNA 136 Japanese rice
AAM91194   80 ---gEQTYAprlff-------------egreQRPTLQDGLSEMEEFYIDTIEKVLKRNK--------ISPSEIDILVVNV 135 thale cress
Feature 1                                     #                                               
1QLV_A    137 TAGVDMPGADYQLVKLLGLSPSVKRYMLYqQGXAAGGTVLRLAKDLAENNk--gSRVLIVCSEITAI-LFHGPnenhLDS 213 Gerbera hybrid cul...
1EE0_A    137 TAGVDMPGADYQLVKLLGLSPSVKRYMLYqQGXAAGGTVLRLAKDLAENNk--gSRVLIVCSEITAI-LFHGPnenhLDS 213 Gerbera hybrid cul...
NP_921952 144 SMFSPAPSLSARVVRRYNLREDVKVYNLTgMGCSATLIALDLVNNFLRTHa--nKVALVMTSESIAPnWYAGNk---RSF 218 Japanese rice
XP_470781 140 NGFFPEPCLASRVVRRYGMREDVAAYNLSgMGCSATLVAVDVGRNAMRARsprpVVALVVSTESLAPhWYAGKe---RTM 216 Japanese rice
BAB10089  155 SLHSPSPSLSAMVINKFHMRSNIKSFNLSgMGCAAGILSVNLANDLLQAHr--gSLALIVSTEALNThWYIGKd---RSM 229 thale cress
NP_918065 174 SIFTPTPVFADMVVNRYKLRAEVQNVNLSgMGCSAGLVSVGLAKNLLQVSpp-gTNVLIVSTEILSSqYYVGTe---RAM 249 Japanese rice
XP_450594 155 SMFSPAPSLASMIVRRFGMPPGTRTYSLAgMGCSAGTVGIDMAARALRVSrr-gGYALVVVTENMSLnWYFGEn---KHM 230 Japanese rice
XP_468364 137 GSFSPSPSLADRVVRRFGLRDDVMAYNLSgMGCSAGLVSVDLARNVMLTRp--rTMALVLTSESCAPnWYTGTd---KSM 211 Japanese rice
XP_470771 137 SMFSPDPSLASMIVHRYGMREDVAAYSLAgMGCSAGLISLDLARNTLATRp--rALALVVSTESIAPnWYTGTd---KSM 211 Japanese rice
AAM91194  136 SMLNSTPSLSARIINHYKMREDIKVFNLTaMGCSASVISIDIVKNIFKTYk--nKLALVVTSESLSPnWYSGNn---RSM 210 thale cress
Feature 1                                                                                     
1QLV_A    214 LVAQALFGDGAAALIVGSGphlav----------erpifEIVSTDQTILPdt----------ekAMKLHLRe-------- 265 Gerbera hybrid cul...
1EE0_A    214 LVAQALFGDGAAALIVGSGphlav----------erpifEIVSTDQTILPdt----------ekAMKLHLRe-------- 265 Gerbera hybrid cul...
NP_921952 219 MLGNCLFRSGGCAYFLTNDprhrrhaklrlrhlvrthtgASDDAYSCALQmed--------dagRPGFHLGkdlpra-av 289 Japanese rice
XP_470781 217 MLAQCLFRCGGAAVLLSNDpahrgrakmelrrlvrsttaASDDAYSCIMQred--------ddgLRGVSISkalpk---a 285 Japanese rice
BAB10089  230 LLTNCLFRMGAAAVLMSSNdhdrdnakyellhvvrknkaKDDRAYRCIYQdid--------sdeKQGVSITkdvis---v 298 thale cress
NP_918065 250 LLPNCLFRMGAAAMILSNSpdhar-----------frlgRVVRTVTAARDsdyrcvfqeedeqgNTGIRLSkdlat---t 315 Japanese rice
XP_450594 231 LVTNCIFRVGSAAALVTDVaarrg-----------dakyELVRTLRTHHGgddaayn-aavqmeDEEGNVGvaltkd-lv 297 Japanese rice
XP_468364 212 MLGNCLFRCGGAAALLTNDpafrsrakme-lrclvrahiGAHDDAHAAAVhred-------adgRLGVSLSkalpk---a 280 Japanese rice
XP_470771 212 MLANCLFRCGGASVLVTNDpvlrgrakm---elgclvraNIAANDDAHACalqredd-dgtvgiSLSKALPkaavrafaa 287 Japanese rice
AAM91194  211 ILANCLFRSGGCAVLLTNKrslsrramfklrclvrthhgARDDSFNACVQkedel----ghigvHLDKTLPkaatrafid 286 thale cress
Feature 1                                                                     #               
1QLV_A    266 --gGLTFQLHr----------dVPLMVAKNIENAAEKALSPl----------gITDWNSVFWMVHPGGRAILDQVERKLN 323 Gerbera hybrid cul...
1EE0_A    266 --gGLTFQLHr----------dVPLMVAKNIENAAEKALSPl----------gITDWNSVFWMVHPGGRAILDQVERKLN 323 Gerbera hybrid cul...
NP_921952 290 hafVKNLRLLaprvl--plpelLRLAFATFLSSGRRSGGKKtspsq--qpltiRMKAGVDHFCVHTGGAAVIDGVGKGLT 365 Japanese rice
XP_470781 286 alrAFAANLQrllprv-lpameIARLAADLAWQNLLQRRRHrgqt----klkiNLKAGVDHICLHAGGVAVIDAVKKSFG 360 Japanese rice
BAB10089  299 agdMLKMNLTslg-------plVLPYLEQFQYVIQHILCKKlkiyesnssytpNFKTAFEHFCIHTGGRAVIQAMEMNLK 371 thale cress
NP_918065 316 aghALKSNIAafgplv-lpaseQLLVAISFLKRKLKQLSGHagkvr---lyrpDFRTAFEHFCIHAGGRGVIDEVQHGLG 391 Japanese rice
XP_450594 298 rvaGAGLRQHiatla---phvlPVSELLRYVWRVARAYVAGnpkav--aaivpDFQRAFEHMCIHSGGKAVIDAVVKLMA 372 Japanese rice
XP_468364 281 avrAFTENLQrlap----rilpAGELARFAARLLLRKLLRRkaaag--aaakiNFKTGVDHFCLHPGGTAVIEAVRKSLG 354 Japanese rice
XP_470771 288 nlrRLAPRILpitel--arfaaQLLITKKLLRRRATAATATkhtgg--dgpriNFKTGVDHFCLHPGGTAVIEAVKRSLG 363 Japanese rice
AAM91194  287 nlkVITPKILpvtellrfmlclLLKKLRSSPSKGSTNVTQAapkag--vkagiNFKTGIDHFCIHTGGKAVIDAIGYSLD 364 thale cress
Feature 1                      #                                                
1QLV_A    324 LKEDKLRASRHVLSEYGNLISACVLFIIDEVRKRSmaegksttgeglDCGVLFGFGPGMTVETVVL 389 Gerbera hybrid cultivar
1EE0_A    324 LKEDKLRASRHVLSEYGNLISACVLFIIDEVRKRSmaegksttgeglDCGVLFGFGPGMTVETVVL 389 Gerbera hybrid cultivar
NP_921952 366 LTEHDLEPSRMTLHRFGNTSASSVWYVLGYMEAKRrlr-------pgDRVLMLTFGAGFKCNSCVW 424 Japanese rice
XP_470781 361 LEERDVEPLRMTLHRWGNTSASSVWYVLSYMEAKGrlr-------rgDKVLMVTFGSGFKCNSCVW 419 Japanese rice
BAB10089  372 LTKVDIEPSKMTLHRFGNTSSSSIWYALSYLEAKRrmk-------kgDRVLQIAFGSGFKCNSAVW 430 thale cress
NP_918065 392 LSDDDVEASRMTLHRFGNTSSSSVLYELAYLEAKGrmk-------rgDRVWMISFGAGFDCNSVAW 450 Japanese rice
XP_450594 373 FGPQVVEPARATLHRFGNTSSSLVFYELAYFEAKRrvr-------agDRLWMLAFGTGFKACSNVW 431 Japanese rice
XP_468364 355 LDSYDVEPARMALHRWGNTSASSLWYVLSYMEAKRrln-------agDRVLMVTFGSGFKCNSSYW 413 Japanese rice
XP_470771 364 LDDDDVEPARMTLHRWGNTSASSLWYVLSYMEAKGrlr-------rgDKVLMVTFGSGFKCNSCVW 422 Japanese rice
AAM91194  365 LNEYDLEPARMTLHRFGNTSASSLWYVLGYMEAKKrlk-------rgDRVFMISFGAGFKCNSCVW 423 thale cress

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