1EBL,1HNJ,1HZP,1M1M,1MZJ,1UB7


Conserved Protein Domain Family
KAS_III

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cd00830: KAS_III (this model, PSSM-Id:29417 is obsolete and has been replaced by 238426)
Click on image for an interactive view with Cn3D
Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.
Statistics
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PSSM-Id: 29417
View PSSM: cd00830
Aligned: 130 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 6-Mar-2002
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1MJZ; Streptomyces priming beta-ketosynthase with bound acyl-CoA
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1EBL_A        2 YTKIIGTGSYLPEQVRTNADLEKXv-------dTSDEWIVTRTGIRERHIAapn--etVSTXGFEAATRAIEXAGIEKDQ 72  Escherichia coli
1MZJ_A       11 FSRVLGVGSYRPRREVSNKEVCTWi-------dSTEEWIETRTGIRSRRIAepd--etIQVMGVAASRRALEHAGVDPAE 81  Streptomyces sp....
AAF84772      5 NVSIAGLAHIDAPCTLTSQEINARlqpmlerigIKSDVFADIVGINARRLWntn--vqTSDVATMAARKALQDAGVAVDR 82  Xylella fastidio...
NP_347450     5 NAVIKDIAYYHPDNLVGNDYFIEHfdk----qgIDIRGLLKSSGRKYRYISdde-netILTMGIKAAEKLIEKSDIDPQK 79  Clostridium acet...
AAN54796      5 RVFINSLAYELAPVVVSSSELESRlaplyqkfrIPMGQLAALTGITERRWWpkg--hqLSDGAINAAHKAIAETGIDVAE 82  Shewanella oneid...
NP_781519     7 NVIIKSVGTYVPHKKVHKNELIQHfeq----ygSQNEAKELMDEIGRETISmmdenetVITMSLASSKICLEKAGLTPND 82  Clostridium teta...
NP_870717    41 DVALASIGVTIPRAQWTSEQIEKDlqplysrlkLPEGRLAMMSGIDSRRVWepg--tvPSGPSIESGRKALEAASVDPNQ 118 Pirellula sp. 1
ZP_00227745  49 NAALLSISHVEAPQVVPSSYFDEVlsgtlerlrLRPGLLEKVAGVRERRWWaeg--qkASDVAAECGAKALSEAGVDASE 126 Kineococcus radi...
CAG35470      6 NVCLDTFGYSLPPRVLSSADIESSlaplydrlhLPEGRLELMSGIRERRLWpkg--mkPSEAAYLAGKKTLDDGGIAAAE 83  Desulfotalea psy...
AAM35125      5 NVSIAGLAHVDAPHTLTSKEINERlqptydrlgIKTDVLGDVAGIHARRLWdqd--vqASDAATQAARKALIDAGIGIEK 82  Xanthomonas axon...
Feature 1                                               #                                       
1EBL_A       73 IGLIVVATTSAthafpSAACQIQSXLGik-gCPAFDVAAACAGFTYALSVADQYVKSGav--------kYALVVGSDVLA 143 Escherichia coli
1MZJ_A       82 IDLVVVSTMTNfvhtpPLSVAIAHELGad-nAGGFDLSAACAGFCHALSIAADAVESGgs--------rHVLVVATERMT 152 Streptomyces sp....
AAF84772     83 IGLVVNTSVSRdylepSTASIVSGNLGvgeqCIAFDVANACLAFLNGMDIAGQMLERGdi--------dYALVVNAETAN 154 Xylella fastidio...
NP_347450    80 INSIIFSTSTPeyispTNAIKLHESIRagskSTVYDLNANCAGMLVAIDQASRAMRSNpd-------ikYSLIVGSDQLN 152 Clostridium acet...
AAN54796     83 LGAVVYTGVCRdqhepATACRIAAALGvskdTAIYDISNACLGVLSGILDIANRIELGqikagmvvsceSARDIVDVTID 162 Shewanella oneid...
NP_781519    83 IDVIISASNTPeflspTGAMLIRDGLNsk-aHQVLDVNCDCIGMLQGLNVATSLLKLNkq-------ykRALVVGAFGCL 154 Clostridium teta...
NP_870717   119 IGALIHASVCRdflepATASRVHHELGlspdCWVYDVSNACLGVLNGAVQIAGMIQSGmi--------sAGIVVGTENSR 190 Pirellula sp. 1
ZP_00227745 127 VGVVISTTVTRphlepAVATSVHHGMDlppsAMNFDIANACLAWVNGVQVASAMIDSGmiryavvlgaeDVRSMHEGTIA 206 Kineococcus radi...
CAG35470     84 VECLLFTSVCRdmmepATSAFVHHKLGlpksCLVFDISNACLGFLDGMVMLANMIELGqv--------kNGLVVSGETAE 155 Desulfotalea psy...
AAM35125     83 IGLLVNTSVSRdylepSTASIVSGNLGvgdhCVTFDVANACLAFINGMDIAARMLERGeidyalvvdgeTANLVYEKTLE 162 Xanthomonas axon...
Feature 1                                                                                       
1EBL_A      144 Rtcd-------ptdRGTIIIFGDGAGAAVLAASee-----------pGIISTHLHADGSYGELLTLpnadrv-------- 197 Escherichia coli
1MZJ_A      153 Dvid-------ladRSLSFLFGDGAGAAVVGPSdv-----------pGIGPVVRGIDGTGLGSLHMssswdqyv------ 208 Streptomyces sp....
AAF84772    155 Rvyektl-ermsapGVTEQEFREEMAALTLGCGav----------amVLARTALVPDAPQYKGGVTrsatewnk------ 217 Xylella fastidio...
NP_347450   153 Rysr-------fdeAITYANFGDSACAIILENTynt---------dnGFIDSDSYTNSSTHDKIVLpakglssti----- 211 Clostridium acet...
AAN54796    163 Nmladpt-mqnfaqSLATLTGGSGAVAVILTDGslplt----nvrkhQLLGASHLSAPQHHQLCQWglqevg-------- 229 Shewanella oneid...
NP_781519   155 Rnsr-------kdnIISYATVGDNSTAMILEVQeee--------ierGFLGHRSFTDSQYIEAIQFpacgmskif----- 214 Clostridium teta...
NP_870717   191 PlmeatiaslnaddQLTRKTVKPAFASLTIGSGscawllthrdlnpgATILEHAIARAHTAHHHLCrsdqdta------- 263 Pirellula sp. 1
ZP_00227745 207 RlqregitrkdflnEFATMTLGCGAAAAVIGRAdehp-------eahRIVGGVSRAGTAHHELCIGd------------- 266 Kineococcus radi...
CAG35470    156 D-------------LLESTIAALNADETFTRKTikss------faslTIGSGSVGCFMRRAEAGETkprlvrgvwrtdtd 216 Desulfotalea psy...
AAM35125    163 RmtspdvteeefrnELAALTLGCGAAAMVMARTelvp-------dapRYKGGVTRSATEWNKLCRGnl------------ 223 Xanthomonas axon...
Feature 1                                                             #                         
1EBL_A      198 --------npensiHLTXAGNEVFKVAVTELAHIVDETLAANNNDRSQLDWLVPHQANLRIISATAKKLgxs-xdNVVVT 268 Escherichia coli
1MZJ_A      209 ------edpsvgrpALVMDGKRVFRWAVADVVPAAREALEVAGLTVGDLVAFVPHQANLRIIDVLVDRLgvpehvVVSRD 282 Streptomyces sp....
AAF84772    218 -------lccgnldRMVTDTRLMLIEGIKLAKKTFVVAKQVLGWAVEELDQFVIHQVSRPHTEAFIKSFgid-paKVMTI 289 Xylella fastidio...
NP_347450   212 -----hnkhlsvkdKLVHWTRFDNTGTFFSAKISIETLLKKNNLKKSDIKKYFLSQFAVQSIQYICAQLned-enKFVFI 285 Clostridium acet...
AAN54796    230 --------hniyreFMRTDAVTLLKEGVELAKHTWEHFLAQRNWLVEQVDKVICHQVGASNRKQVLSALnip-peKEFPT 300 Shewanella oneid...
NP_781519   215 ------dknidefeKRLRWDNFNSHFIPQSSADVITELLTDYNYKPEDVTQFFLSQFSIEYNELTMDAMslp-hnRFTFI 287 Clostridium teta...
NP_870717   264 --------gagmqpLMETDSETLMAEGIATGVAALNELLQQSGWSRDQIDRSVCHQVGSRHRIGMLEAMqlp-etRDSVT 334 Pirellula sp. 1
ZP_00227745 267 --------------MNHMKTDAKLMLTEGIEIVVDAFNAGDELWGWRDAEKFVIHQISKVHTETLVERIgvd-aaKVPMT 331 Kineococcus radi...
CAG35470    217 hihlcqgdaqggetTLMQTDSEELLLRGVDTAAAAWDAFAAPGWRNEEVDAYCCHQVGVAHFRMLFDRLgls-eeKNFQT 295 Desulfotalea psy...
AAM35125    224 -------------dRMVTDTRLLLIEGIKLAQKTFMAARQVLGWAVDELDQFVIHQVSRPHTAAFVKSFgid-paKVMTI 289 Xanthomonas axon...
Feature 1            #                                         
1EBL_A      269 LDRHGNTSAASVPCALDEAVRDgrikpgQLVLLEAFGGGFTWGSALV 315 Escherichia coli
1MZJ_A      283 AEDTGNTSSASVALALDRLVRSgavpggGPALMIGFGAGLSYAGQAL 329 Streptomyces sp. R1128
AAF84772    290 FREYGNIGPASVPIVLSKLKELgrlkkgDRIALLGIGSGLNCSMAEV 336 Xylella fastidiosa 9a5c
NP_347450   286 GDKYGYTGTTSPLLAFAKTIENnelnkgDYVIFWTVGAGSTCECILY 332 Clostridium acetobutylicum ATCC 824
AAN54796    301 YQLLGNMGTVSLPVTAAMAHDQgflrpgDQVSFLGIGSGLNCMMLGI 347 Shewanella oneidensis MR-1
NP_781519   288 ADKYGYTGPCSPLLALHDRIQEkpfnesELCIMCSVAAGCIITALLY 334 Clostridium tetani E88
NP_870717   335 FPALGNTGSVALPLTVAAAAATgelsagDRTAMLGIGSGINSVMIAA 381 Pirellula sp. 1
ZP_00227745 332 FPQWGNVGPISLPMTLAATAPEls--pgDRVIAMGVGSGLNTAMLEL 376 Kineococcus radiotolerans SRS30216
CAG35470    296 LPFLGNVGTVSAPITLAMAMEEgafkpgERAVMLGIGSGINSIVLGI 342 Desulfotalea psychrophila LSv54
AAM35125    290 FGEHGNIGPASVPIVLSKLKELgrlkkgDRIALLGIGSGLNCSMAEV 336 Xanthomonas axonopodis pv. citri str. 306

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