Conserved Protein Domain Family
SCP-x_thiolase

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cd00829: SCP-x_thiolase (this model, PSSM-Id:29416 is obsolete and has been replaced by 238425)
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.
Statistics
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PSSM-Id: 29416
View PSSM: cd00829
Aligned: 125 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 6-Mar-2002
Updated: 9-Mar-2011
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
A39368     17 VGVGMTKFMKPgg---enSRDYPDLAKEAGQKALADAQIpys----avEQACVGYVYGe-------sTCGQRAIYHSLgl 82  Norway rat
AAB48108   10 SAAYTSKPGSSr-----vRQTFKEMIVESAYQALNAIKMhpr----elQAVAYGYHGEgis---eygGLGPTISDALGis 77  Pseudomonas fluore...
NP_420774   9 IGAGQFTYRGEaa----nSPSPLELLKVAAERAVLDAGLsgtvlaeldALAVVAFSID---------APGGLSKLPLPrl 75  Caulobacter cresce...
EAA75378   12 IGIGESRQKDFti---etCREPAELILSAIRDASKDSSInav---eklDSISVVPPWSwn-----ydDLPKLLAQRLG-- 78  Gibberella zeae PH-1
CAE27197   14 AGVGEIADHPKdi---aqGLEPLALLEAAVQRAGDDSAVsll---pqiDSLDVVNFLSwr-----yhAPAEQLATRLGi- 81  Rhodopseudomonas p...
NP_959832   9 VIVGVGQFTERiedsgyrGMSSVELATEAARAALHDCGAda-----taLAAAVDTVAAirqfelsgrTPAPMGKSNNYp- 82  Mycobacterium aviu...
NP_960511  11 IGYGQVNHRDDidp-avrSVEPVDLMAAAVERAADAAVIea------vDSIRVVNILSaq-----yrDPGLLLGQRIGar 78  Mycobacterium aviu...
AAN51312   22 EWTGERKVLEHykksiydLLEFLEMKPETLKEILTDFVSi--------EPASLGKAGY---------GHSARIANELGyt 84  Leptospira interro...
NP_377304   2 VSIAEVSFIKIdr---yyEYSEKDLVIEAYKQIETKVKDyi-----kpDVVIVSSGYAesig--kssLSAVKLSSSLGf- 70  Sulfolobus tokodai...
NP_342063   7 NSSSMIPIDRYy------EYDIYDLVIEAYKNFEGEYDVns------iDLIVVANAYSqkln--nasLIAPKIAEKIGkp 72  Sulfolobus solfata...
Feature 1                         #                                                           
A39368     83 ---------tgIPIINVNNNCSTGSTALFMAQQLVQGGl----------aNCVLALGFEKMEkgsl-----------gtk 132 Norway rat
AAB48108   78 ----------pAPTFMSTANCTSSSVSFQMAHQMVASGe----------yDIVLCGGFEKMTdhfn-----------yae 126 Pseudomonas fluore...
NP_420774  76 sdppaslaravSASPRWSVYTETGGNSPQQAVNVVCERiaq------gesDLALVTGAEFLGslmkrmkgglgfegwgdd 149 Caulobacter cresce...
EAA75378   79 -----------IQPSHLELASHGGNTPALLCDKAAARVasg-------dvKMAVVTGGEALAslfacqkagkipppgwte 140 Gibberella zeae PH-1
CAE27197   82 -----------APRHCFYGPVGGESPIRFIHEAALRIArg--------eaKVAVVCGAEAQStatkaara---kldlpwt 139 Rhodopseudomonas p...
NP_959832  83 ----------rSVARRIGAAPARAVLEPIGGQGPQHLVtefagiiaagdaEVVMIFGSENTSsiryfad-----rekpdh 147 Mycobacterium aviu...
NP_960511  79 ----------dFGTLYTPVGGNVPQSLVNQACLDIQRGr----------aNVVLLAGAETWRtrrglrak---ggklvwt 135 Mycobacterium aviu...
AAN51312   85 ----------gFRSHLMDLGGASVTGALGQARIILQSDp----------eAVVLIAAADIPKs----------------- 127 Leptospira interro...
NP_377304  71 ----------kGVRTFRIENGDNGGPSIYTAYSLIKSGl----------aKSVLLIGVDKFSdlaskq-------lndvl 123 Sulfolobus tokodai...
NP_342063  73 ----------nVPSIKVDNADASGGAALLTAYSLIKSNm----------vNSVLIVGVEKQSdyps-----------kyl 121 Sulfolobus solfata...
Feature 1                                                                                     
A39368    133 YSDRSNPLEKhidvli-----nkygmSACPFAPQLFGSAGKEHMETYGTKv--------eHFAKIGwkn---hkHSVNNP 196 Norway rat
AAB48108  127 YIGSSTECEYd--------------yFLGISHTDAFALATAEYFEKFGYAgre-----adVLATFGrqm---riYAHNTP 184 Pseudomonas fluore...
NP_420774 150 ITTAPQRIGDprpgvtr--qeaahglGYPVNTYPLFENALRARDGRSQEEhq-------kQLGAFFapf---tkVAAANP 217 Caulobacter cresce...
EAA75378  141 MSPDAKRYSPgdtslkkgagathsigNPIQVYPLYENAYRKQNQQSYIENhhesa-elytQFDKIAcqhp-nswRAEETP 218 Gibberella zeae PH-1
CAE27197  140 PFAHDAPEPKrgaafq----qpiastLGVARPITVYPLYEAATAAHWGQTprq-----alDESGVLwsr--yaaAAERNP 208 Rhodopseudomonas p...
NP_959832 148 SETVEGSLEDrgfgyegl-fddytvaHGLIGAPAQYGLLENARRARLGLSvadyrrrmgeLFAPFTk-------VAAKNP 219 Mycobacterium aviu...
NP_960511 136 EQDRSVPMAEvsgedvam-ageaeirISLDRPAYVYPLFEQALRVATGESve-------dHLTRIGrlwarfnaVAVDNP 207 Mycobacterium aviu...
AAN51312  128 AFKQISDLKRlnetvc----hplyelNYGATLISMYGLLMKRMMYENSITq--------kDLEQITkrf---raNAIINP 192 Leptospira interro...
NP_377304 124 AMNLLHDHEY----------------HLGLTPHSYAAILAKLYMKKYNVPy--------eYFANWPlkm---hdNAVENP 176 Sulfolobus tokodai...
NP_342063 122 YDAISTNLDDym-------------fYNGISSHSVAALLMRQYMKRYGVDr--------nYFANWAikm---hkNATENP 177 Sulfolobus solfata...
Feature 1                                                                                     
A39368    197 YSQfqd----eySLDEIMKSRPVf------dFLTVLQCCPTSDGAAAAIVSSEefvqkhg------lqskaveIVAQEMV 260 Norway rat
AAB48108  185 TATrygv--pvpSLETLKNSEACgs----mlAWGEASGCAILVAEHLAHRYTTqpvfv-----------rgcaYTGVSHY 247 Pseudomonas fluore...
NP_420774 218 HAWfpvertaeeLVTVTDRNRMVgy-----pYPKYLNAIMEVDQSAAVLIASVrkarelgv-----pedkwvfLHGCADA 287 Caulobacter cresce...
EAA75378  219 RTLe-------dIKTVSKRNRMIct----pyPLLMNAFNGVNLAAACIITSTEyatklgv------prekwvyVTGGAGS 281 Gibberella zeae PH-1
CAE27197  209 NAWikrafapneITTPSSDNRLIaw-----pYTKLMVANPSVNLGAAVLLTSLakaraagi-----pedkliyIHGGASA 278 Rhodopseudomonas p...
NP_959832 220 SASapv----erSVDELITVTPSnrmicdpyPRLLVARDQVNQGAAALLMSVAaarrlrv------peerwvfLHGHADM 289 Mycobacterium aviu...
NP_960511 208 HAWirt----phSADDICRAGPHnrmi-swpYTKLMNSNNMVDQGAALVLTSVeqarrlkv-----pperwvyPLAGTDA 277 Mycobacterium aviu...
AAN51312  193 RAS---------VYGQEITEKQItrt--ivdPYSAPMIAIVTDHGFATLLVSEkkakklqtqgkikkginpmyLIGAGQA 261 Leptospira interro...
NP_377304 177 FAYlrf----ktDLKTITSSQLVs------ePLRIFDTAARADGAGIILLTDDevak-------------kytDTPVYLA 233 Sulfolobus tokodai...
NP_342063 178 FAYlrf----qvDLNTVINSQIIs------dPVRLFDVGARADGAAILLLSNNkt----------------esAVKINKI 231 Sulfolobus solfata...
Feature 1                                                        #                            
A39368    261 TDMPSTFEeksvi------kmvgyDMSKEAARKCYEKSGLGPSDV-DVIELHDCFSTNELLTYEALGLCPEGQGgal--- 330 Norway rat
AAB48108  248 FGTRYHNPtlkypglpkdvgmavsANSIACAEIAYKKAGITAKDI-DVAQVYDLLGAGLIQMESMGVCGPGQAGdfv--- 323 Pseudomonas fluore...
NP_420774 288 CDLWYPLErqdy---------hssPAMRLTGQRAFEMAGISVDDL-DVIDLYSCFPSAVRIGAEEIGLALDDPR------ 351 Caulobacter cresce...
EAA75378  282 NDSSDFWErsny---------yssPAIEYSIDNALKAAGLKKDEI-DCFDFYSCFPIVPKIACKHVGLDLLNPKkpit-- 349 Gibberella zeae PH-1
CAE27197  279 EEPRDYLArdq----------fvqSHAQNAVLETIKAMVGGDGRAfDAIELYSCFPVVPKMARRTLGLGDDVEPtvtggl 348 Rhodopseudomonas p...
NP_959832 290 VDQPLLDRldl----------tynSASVLAVQEALAGAGIGIDDV-STFDLYSCFPVPVFNFCDGTGLATDDPR------ 352 Mycobacterium aviu...
NP_960511 278 HDTASIAErhel---------hrsAAIRIAGARALQLAGLGIDDV-DHVDLYSCFPSAVQVAAAELGLGLDDPArplt-- 345 Mycobacterium aviu...
AAN51312  262 VHSEYFMFkgd-----------faTPAGRAGDLAFSTAGIEREEI-DYAWIYDCFVGMIILQSSEYFGVSKKEI------ 323 Leptospira interro...
NP_377304 234 NVHGAIYEyi-------------yDLSLPSIRLALNELKYTPNKN-DIIEIHDSYSILAALELEELGLGEKGKSlle--- 296 Sulfolobus tokodai...
NP_342063 232 LSAQARYDf---------------SPSLPSVRMLRDKLELKFSER-TGIDIHDSYSIMAALMLEEAGIFESGKSlhn--- 292 Sulfolobus solfata...
Feature 1                                              #                                      
A39368    331 -------vdrGDNTYGGKW----------VINPSGGLISKGHPLGATGLAQCa----ELCWQLRGea----------gkR 379 Norway rat
AAB48108  324 --------leGGIALDGQL----------PLNTDGGNIGRGHASGCDGILHIt----ELFRQLRGes-----------nN 370 Pseudomonas fluore...
NP_420774 352 ----------GLTITGGLPyfggpgnnyaLHAIAEMVAKLRARPGAYGLSTAng--wFLTKQSVGiy----------stR 409 Caulobacter cresce...
EAA75378  350 -------llgGLTSFGGAGnny----slhAIAEMVRVIRKGKYQNGLVLANGg----VLSWQHAIclsakp--krngsaY 412 Gibberella zeae PH-1
CAE27197  349 tffgaplntyMTHAACAMArrlrdgakvgLLYGQGGFVTKHHGLIVSGTPPQqplseDVSVQAKAda-----------aY 417 Rhodopseudomonas p...
NP_959832 353 ----------GLTLTGGLPyfggpgnnysLHGIAETVSEMRDRPGQFGLVAAng--gIMSKYSVGvy----------stT 410 Mycobacterium aviu...
NP_960511 346 -------vtgGLTFAGGPWsny----vmhSIATMAELLVANPGRRGLITANGg----YLTKHSFGvygteppaefrwedT 410 Mycobacterium aviu...
AAN51312  324 ----------SESLKNGIIkfkn--gktiLVNQMGGILNYQAAMSVSAATGLvd--vAAHYGLYSke-----------sP 378 Leptospira interro...
NP_377304 297 -------ldsYQINYSGGL----------KARGYPGGATAIYQLAEVVMQLR-----GEFPGKKA--------------I 340 Sulfolobus tokodai...
NP_342063 293 -------ldsVNVNLGGGL----------KARGHVGGASAIYQLAEAHMQLI-----GSFKGKKA--------------S 336 Sulfolobus solfata...
Feature 1                                                
A39368    380 QVp---------gAKVALQHNL----------GLGGAAVVTLY 403 Norway rat
AAB48108  371 QVk---------dARIGVSQNL----------GGYAAHNSVIV 394 Pseudomonas fluorescens
NP_420774 410 PVegkw----erePPSVIQARIdalphpeiieKPQGRAVIETY 448 Caulobacter crescentus CB15
EAA75378  413 EApavl---dngqTSQGPTFTA----------QAQGEAIIETY 442 Gibberella zeae PH-1
CAE27197  418 GVvprfv-teasgDGTVETFTViyd-----grGEVQHGVVMLR 454 Rhodopseudomonas palustris CGA009
NP_959832 411 PVnwkpdnsaalrAEVAARPTVpv------tvRADGRATIETY 447 Mycobacterium avium subsp. paratuberculosis str. k10
NP_960511 411 QSavd------rePTTDAAVEWe---------GVGTVEAWTTP 438 Mycobacterium avium subsp. paratuberculosis str. k10
AAN51312  379 NVl---------iTRPGKTLLGg--------nGGIDSINSVAI 404 Leptospira interrogans serovar Lai str. 56601
NP_377304 341 GE-----------SGVVISADD----------LVTSSYISILK 362 Sulfolobus tokodaii str. 7
NP_342063 337 VD-----------NYIVISSDD----------LGMVSYGINLS 358 Sulfolobus solfataricus P2

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