1EBL,1EE0,1QLV


Conserved Protein Domain Family
init_cond_enzymes

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cd00827: init_cond_enzymes (this model, PSSM-Id:29414 is obsolete and has been replaced by 238423)
Click on image for an interactive view with Cn3D
"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.
Statistics
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PSSM-Id: 29414
View PSSM: cd00827
Aligned: 84 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 6-Mar-2002
Updated: 9-Mar-2011
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EEO; Gerbera 2-pyrone synthase with bound acetoacetyl-Coa
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1EBL_A        2 YTKIIGTGSYLPEQVRTNADLEKxvdtsd------------ewivtrTGIRERHIaap---------------------- 47  Escherichia coli
1EE0_A       21 LATILAIGTATPPNCVAQADYADyyfrvtksehmvdlkekfkricekTAIKKRYLaltedylqenptmcef--mapslna 98  Gerbera hybrid c...
NP_068874    12 LAYISDCSVYLPVWKLKRDEISKe-----------------------TGMPSMGGer----------------------- 45  Archaeoglobus fu...
NP_885019    19 VSNILAIGVHLPRLRLSRRAMANalgwl--------------sggagAGKGSRTLa------------------------ 60  Bordetella parap...
NP_420244     1 MVGIAAWGAYAPRLRLSRKAVTEanawva-------------pnlkaKGKGERSManw---------------------- 45  Caulobacter cres...
NP_623458   137 SRLKEGVSLEEIERQIENKAVPLrfng-----------------kivGCVKKAHDkditlssh----------------- 182 Thermoanaerobact...
ZP_00214919  29 PVDIEAWAAERDYPAQRAAAIAH------------------------SGSRYFHMald---------------------- 62  Burkholderia cep...
NP_348630    10 YVKLLGIGACLPGNPIKFEDINNyigqi---------------pnapKKIKTWISrvqpimkemlgidyc----yyafng 70  Clostridium acet...
CAC14302    109 SFDLVKLTADFSKAVVEKLKAHElfsdaelekf----kdseeidsikTFVNEHHAeglynmgelvgcvkrahevdnslta 184 Clostridium stic...
AAG04387      3 KVKLAAITCELPARSYENDDPVFaavpdlses------wwqfwgvnrRGYFDPRNge----------------------- 53  Pseudomonas aeru...
Feature 1                                                                                       
1EBL_A       48 -----netVSTXGFEAATRAIEXAG--IEKDQIGLIVVATTSAtha---------fpSAACQIQSXLGik----gCPAFD 107 Escherichia coli
1EE0_A       99 rqdlvvtgVPMLGKEAAVKAIDEWG--LPKSKITHLIFCTTAGvd----------mpGADYQLVKLLGls---psVKRYM 163 Gerbera hybrid c...
NP_068874    46 -------aVAHWDEDSITMAVEAAR--KFDGAFDAVIFASSSPpfr---------ikQCASFIASALDl-----pDSTFT 102 Archaeoglobus fu...
NP_885019    61 -------yWDEDSVTMAVAAARHALarQAAPAIDALQFASTTPp-------------FAEPQNAAFVRaa---lrLPATT 117 Bordetella parap...
NP_420244    46 -----dedALTMAVEAARDALGPDD--DRSHIASLYFASTTAPfad--------rlnAGIVSAALTLEk-----sITASD 105 Caulobacter cres...
NP_623458   183 -vmlenlaTKASAVLAFKHLLKNTG--MSPEEIDYIIECSEEAcgdmn----qrgggNFAKAIGEIVGcs----nATGAD 251 Thermoanaerobact...
ZP_00214919  63 ------tsETDLAIAAAGRLLDTAR--VHPSDIGAIVHVHTQQfsvp------paprSLPHELAAQLG-------IEPLW 121 Burkholderia cep...
NP_348630    71 ktrkfdedNLSLSVKASKLALQDAK--IKPQDIDLLIYAGNYSyq----------mpPISTRIQEELGid----iCSEYH 134 Clostridium acet...
CAC14302    185 himfenlvVKASGVLAVKHLMKNSS--VKADEVEYVIECSEEAcgdmn----qrgggNFAKSIAEACSft----nATGSD 254 Clostridium stic...
AAG04387     54 -------nEFSLVVRAAERLLRSSD--TAPDSVDMLICSASSPimtdagdvlpdlrgRLYPRMANVLSkqlglsrALPLD 124 Pseudomonas aeru...
Feature 1             #                                                                         
1EBL_A      108 Va--aACAGFTYALSVADQYVKSGav-------kYALVVGSDVLARtcdp----------tdrGTIIIFGDGAGAAVLAA 168 Escherichia coli
1EE0_A      164 Lyq-qGXAAGGTVLRLAKDLAENNkg-------sRVLIVCSEITAIlfhgpne----nhldslVAQALFGDGAAALIVGS 231 Gerbera hybrid c...
NP_068874   103 MditdTMRAATDALITANEFVDSGrf-------sRVLVVAGDKIPTkp-------------gtLYEQLYGDAAAAVVVEK 162 Archaeoglobus fu...
NP_885019   118 Lt--qDVHGTPRAGLLALHMALESg--------tRTLVAAADLPTAlp-------------gsTAEARAGDGGAAVLTGD 174 Bordetella parap...
NP_420244   106 V----TGSQRCGLTALGQALAAGG----------TALVAVGERRKAra-------------vsAQELDFGDGAAAFVISD 158 Caulobacter cres...
NP_623458   252 Vr--gFCAGPAHALLNAASLVKAGvf-------kNIVVVAGGATAKlgmngr------dhvkkGLPVLEDVLGGFAVLVS 316 Thermoanaerobact...
ZP_00214919 122 L----GSVAQLNCVSVAAGIETVRalmrrypqmdAALVVSSDRVYGedy-----------rmrQMTGVQCDGAAAMLIAR 186 Burkholderia cep...
NP_348630   135 Ih--sNCSSIYKAIKLADTFLKSGey-------kNALVVSSMVSSAhfipeyynqqkvtkedvFLRWYLCDGAGAVVLSS 205 Clostridium acet...
CAC14302    255 Tr--gFCAGPTHALINAAALVKSGvy-------kHVVVVGGGATAKlgmna-------kdhikKNIPVLEDVLGGFAVLV 318 Clostridium stic...
AAG04387    125 Sq--mECASFLLNLRLAASMIRQGka-------eKVLVVCSEYISNlld-----------ftsRTSTLFADGCAVALLTR 184 Pseudomonas aeru...
Feature 1                                                                                       
1EBL_A      169 See-------pGIISTHLHADgsy---------geLLTLpnadrvn---------pensihLTXAgn----------eVF 213 Escherichia coli
1EE0_A      232 GphlaverpifEIVSTDQTILpdt---------ekAMKLhlre--------------ggltFQLHr-----------dVP 277 Gerbera hybrid c...
NP_068874   163 Eg--------gAKILGYSTSTk-------------PLPGsw-------------------mLADDdtvr------dydMR 196 Archaeoglobus fu...
NP_885019   175 Ep---------GLLRYLGGASlsapf----tdryrAAGHdypqe------------weerwLREAg------------YL 217 Bordetella parap...
NP_420244   159 Gpg------aaEFLGRGSVTDd-------------FVDH----------------------FRGDdggfdyyweerwiRD 197 Caulobacter cres...
NP_623458   317 Qd--------dGINPIIRLDSigrhtigagaspqaVMHAvaveplerlg--lkvtdvdkysVEMQnpeite-pagagdVP 385 Thermoanaerobact...
ZP_00214919 187 Nstk----nrlGGIAIETHAKwh----------rgSDTVa--------------------aNEADl-----------iMM 221 Burkholderia cep...
NP_348630   206 Kdtvd---ngfYLKNTYVESAggk--------kesVMGNnfpsyfsnpltayengehhirqVTLDkmr-------kyvVD 267 Clostridium acet...
CAC14302    319 Sed-------dGISPVFNTDLvgrhtvgtgsspqaVITSlitmpldkgg--lkitdiskysVEMQnpditk-pagagdVP 388 Clostridium stic...
AAG04387    185 Gddd-----scDLLASAEHSDatf---------yeVATGrwrlpenptg--eakprlyfslFSDGqn----------kMA 238 Pseudomonas aeru...
Feature 1                                           #                                           
1EBL_A      214 KVAVTELAHIVDETLAAnnndr------sqldWLVPHQANl---------rIISATAKKLgxs--------xdNVVVT-- 268 Escherichia coli
1EE0_A      278 LMVAKNIENAAEKALSPlgitd------wnsvFWMVHPGGr---------aILDQVERKLnlk--------edKLRASrh 334 Gerbera hybrid c...
NP_068874   197 VDARYGYAASVQKAAMP---------------LFAKLGLSp---------aDIDRIVASApdpks---yqgllKAVGArp 249 Archaeoglobus fu...
NP_885019   218 ELVHDAIGRALQAASLRpeq---------vdhFVLPCPVPg----------VAAAVAAKAglg-------qarLASAL-- 269 Bordetella parap...
NP_420244   198 EGIVKLVPPAIRKALEVsglsa-----sdvdhFCFPSTFSg----------MAATVAKSVgi---------kpEAVRDn- 252 Caulobacter cres...
NP_623458   386 KANYKMIAALGVKRGDIeksqidefilkhgmpGFAPTQGHipsgv-pvlghIREKILKGEikramiigkgslfLARMTn- 463 Thermoanaerobact...
ZP_00214919 222 EWPYTRKAIDAAVALEPhald--------ayeLVLPHNADlpgwn--alcrAMRVPAERLya----------eNIHARgh 281 Burkholderia cep...
NP_348630   268 ENGKTIFYNALKRMLDKqkidl------stlkYFMVNMPSk---------fVREYITNECvg----------lGISPDkf 322 Clostridium acet...
CAC14302    389 EANYKMIAALGVKRGDLeksslptfgkehgmpGFAPTQGHipsgvpfigfaIDEMKENKLd-----------kVMIVGkg 457 Clostridium stic...
AAG04387    239 SFVPTNVPIAMRRALEKaglgs------ddidYFVFHQPAp---------fLVKAWAEGIgar--------peQYQLT-- 293 Pseudomonas aeru...
Feature 1                     #                                                       
1EBL_A      269 ---------LDRHGNTSAASVPCALDEAVRDgrik--------------pgqlVLLEAFGGGFTWGSALV 315 Escherichia coli
1EE0_A      335 --------vLSEYGNLISACVLFIIDEVRKRsmaegkst-------tgegldcGVLFGFGPGMTVETVVL 389 Gerbera hybrid cultivar
NP_068874   250 e-----efyFDSVGIAGSAHPLLLLATQLEReg-------------------rILLGGYGEGADVIAVEI 295 Archaeoglobus fulgidus DSM...
NP_885019   270 ---------AENCGDTGAAHAFVMLGRALEDaap----------------gqkVLVAQFGQGATALLFEA 314 Bordetella parapertussis 1...
NP_420244   253 --------lAALMGEAGCAHGPIMLAHALEQakageiilvaqfgqgaealvfrATGEGTRPARGVTGSLA 314 Caulobacter crescentus CB15
NP_623458   464 --------lFDGISMIIEANPGVKEEKGVEEke-------------------iRKMIAKALRDLAEHLIG 506 Thermoanaerobacter tengcon...
ZP_00214919 282 accsdfpinLADVGLDAVARGQRVLGVMQSN----------------------CGAYAAATLHPVGRHDA 329 Burkholderia cepacia R18194
NP_348630   323 y------svSQKIGYAGPPAAIISLDRLLKNndf----------------knnDLIFSFVLEVSKFMQGG 370 Clostridium acetobutylicum...
CAC14302    458 s------lfLGRMTNQFDGVSFVMEKNDGKGedkapq----------vdeqqiKSMIADAMRKLAENLGQ 511 Clostridium sticklandii
AAG04387    294 ---------MGDTGVMISVSIPYTLMTGLREgkir--------------pgdrIVMAGAATGWGFAAQVW 340 Pseudomonas aeruginosa PAO1

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