4F3T


Conserved Protein Domain Family
ArgoN
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pfam16486: ArgoN (this model, PSSM-Id:293095 is obsolete and has been replaced by 465134)
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N-terminal domain of argonaute
ArgoN is the N-terminal domain of argonaute proteins in eukaryotes. ArgoN is composed of an antiparallel four-stranded beta sheet core that has two alpha helices positioned along one face of the sheet and an extended beta strand towards its N-terminus. The core fold of the N domain most closely resembles the catalytic domain of replication-initiator protein Rep. The N domain is linked to the PAZ domain via linker 1 region, and together these three regions are designated the PAZ-containing lobe of argonaute.
Links
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Statistics
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PSSM-Id: 293095
Aligned: 429 rows
Threshold Bit Score: 57.228
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4F3T_A         30 RPd-fGTSGRTIKLQANFFE--Mdip----kidIyhYELDIkpek-------------cprrVNREIV---EHMVQHf-- 84   human
ESA05617       19 RPekpGSAGKVVELKTNFIA--Vstef--kypkVhyYSFEVsdakkk----------kagrkDSQKVF---EQMKKNq-- 79   Rhizophagus i...
CAZ37318      114 RPdggGKLGKEIYVTVNCWD--Fsik----pkiVymYRAEAlavyrgdegn--rteirmsakDKRALI---KQVADSlh- 181  Schistosoma m...
XP_009269096    9 akpkqfisrnqaTVTSNLFP--MrrfpkdappsIyvYDVTIeatkpk----------vrnwkDNLRAM---RFFL-An-- 70   Wallemia icht...
CAZ37317       95 RPdrgGTVGRKVTVTSNCWDlaFlp------ktVylYFLEAsavyrvgadegskteirmppkEKRALI---QQVVDSfp- 164  Schistosoma m...
CDJ04181        5 RPg-rGTIGRKIVVEVNCWDfdVsd------vlVlmYDITL------------------------------TKLLSAdgk 47   Echinococcus ...
CDJ04179       58 RPg-rGTAGKRVSVEVNCWDfdVsd------vsVlqYTITP------------------------------TKLLNVegk 100  Echinococcus ...
CDS30752      762 RPs-fGTKGKSTKVVVNCWDmeIgnti------lhrYDIQPvnlft------------vnenNQEKILtdnRKRLKRhms 822  Hymenolepis m...
CDS25403       85 RPs-iGTVGKPTRVVVNCWDleIgntt------iyrYDVQPvnlfi------------vnenNQERILtdnSRLLQRhms 145  Hymenolepis m...
ERZ98309       21 RPg-iGNLGQKVNLRANHLK--Iskfpn-lklyLynYNVTSssgrt------------igkkVRWKVF---EEIKKQ--- 78   Rhizophagus i...

4F3T_A         85 ---------------kT-QIFgdrkPVFDGRKNLYTAmplpigrdkvel-----------evtlpgegkdriFKVSIKW- 136  human
ESA05617       80 ---------------kF-GAKa--lPVFDGGQ-VYSIsqldighrketrshs-----vkipvdadgsgrekdLKVEVKY- 134  Rhizophagus i...
CAZ37318      182 -----------------------dcIIYDGGHDIYSAdrlpgigkvptea------------emkivdplgrdnLVLKYh 226  Schistosoma m...
XP_009269096   71 ---------------eV-NYGs--tCAYDGQSLLYSSqplpfdseisvifnlpaesetpivdkatgekkgavNKISLKP- 131  Wallemia icht...
CAZ37317      165 -----------------------esIIYDGGHSVYSEsplpgittdpve------------keidikdplgrdRLLLTY- 208  Schistosoma m...
CDJ04181       48 eiklkekgigkyvrsiAeRKRg--dVFHDGGRILFSLgpldgkdgevln------------fsekiadplqndDLTIEY- 112  Echinococcus ...
CDJ04179      101 vlineekglwkfvkdaMkGIRd--dVFYDGGQHLYSLkpldgeeggqat------------csakvsrhpqndDLTIEY- 165  Echinococcus ...
CDS30752      823 -------------------------hvfNQERFLYSLkpldngrfpins------------pialalpetegeNVKLRY- 864  Hymenolepis m...
CDS25403      146 yvfnl----------------merdafsDGERFLYSIrpldnskfpids------------pitlalpeiegeSLRLRY- 196  Hymenolepis m...
ERZ98309       79 ----------------KkFGKs--lPIFNWNDMIYSStklfleqdefelp----------lppsepagkittFKIKIKF- 129  Rhizophagus i...

4F3T_A        137 ---V----ScVSLQalhdalsg----rlpsvpfeTIQALDVVM 168  human
ESA05617      135 ---Q----GeIDLSpigdyvkekstsawdgniqsSLTVLNafa 170  Rhizophagus irregularis DAOM 181602
CAZ37318      227 lmeV----QtVSTDdvqqyvenpk-atslnipqeSIRLLDCIL 264  Schistosoma mansoni
XP_009269096  132 ---V----SvISTDianns-----------gvneLIAALNTVV 156  Wallemia ichthyophaga EXF-994
CAZ37317      209 ---RvmevQkVSTAdinhfitspk-atslnmpqeSIRLLDCIL 247  Schistosoma mansoni
CDJ04181      113 ---VakrvGnISAReireyldnsr-sktsdlpqpAINMLDdli 151  Echinococcus multilocularis
CDJ04179      166 ---TvrrvNsVSIGhiseylanrh-sktselpqsAINILNNLi 204  Echinococcus multilocularis
CDS30752      865 ---IikdiGtISAQpimdyltkgp-trtdqlpqdAINMLDNLL 903  Hymenolepis microstoma
CDS25403      197 ---IikyiGtISTQhlldyltkgp-trtdqlpqdLINMIGNLL 235  Hymenolepis microstoma
ERZ98309      130 ---K----EeFSLQhikdfmesk--qawnknvqtCMNALNAYl 163  Rhizophagus irregularis DAOM 181602
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