Conserved Protein Domain Family
WASH-7_N
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pfam14745: WASH-7_N (this model, PSSM-Id:291415 is obsolete and has been replaced by 434178)
WASH complex subunit 7, N-terminal
This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Links
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Statistics
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PSSM-Id: 291415
Aligned: 20 rows
Threshold Bit Score: 529.557
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VXH9         11 GSFISEHDGKLKLLRDKVPNRDvseSA-------QCVYMSPVVEVNFMG-NDSMAPDR-SFEeS-ELVANKPLTTLANLC 80   fruit fly
XP_003294299   35 NQFAVDYAQQIWRIEEALDDTL---NE-------VWDINIDPLSIYNKPyEQQDLIEL-VKT-D-HKIFNKVMLVFSSLC 101  Dictyostelium...
XP_009021212    8 eSFVNDFTANLHNLQISTDVFS---HT-------VWDIVLNPIALTFHPnELASIDEL-IET-D-NIIFDKILRVFASLC 74   Helobdella ro...
XP_002431643   28 GKFIEKHTNKLRSIEESFTESN-------------KNFGYDPINVKLNGwEQIELINL-INT-D-NKILNKVVLVLASLC 91   human body louse
XP_011258277   28 GEFFENLMEKSWRGDSML-----------------EYIIEGPLRLVYKAkESISILSL-VEM-E-NKALSKLLAAVAGTC 87   Florida carpe...
XP_001602448   28 GQFFENLAEKCWQESSSL-----------------EYVIEGPIRLIYKVyEDISILSL-AET-E-NKTFSKLLASVGGTC 87   jewel wasp
XP_008199002   29 GNFLDKYSADLNHFKEKLPNR--------------FNVRLEPILLQSSRtENVSLLHL-VHS-D-NKLLSRILASLAAVC 91   red flour beetle
XP_624277      28 GQFFENLAKQTWKKDSTL-----------------EYFMEGPLRLVYKPvEDISLISL-IEM-E-NKFLSKLLAAVAGTC 87   honey bee
XP_001355110   20 GSFMEEHDSAMKSLKNEMLSLNtveSV-------TLVAMTSPIELNYGSgANARFCDTsVEE-S-ELVANKPLKTLANLC 90   Drosophila ps...
XP_002067587   11 GAFIEEHDAHLDKLKTAISPGG---NDkltaatvSLSLVAPPVEMNYGn-ANFMISEM-NAE-AaELLANKPLTTLANLC 84   Drosophila wi...

Q9VXH9         81 NQCRNLSRKAKR--FQLAFLFSDfrlddtlpphTHtSEGS--------AGLEGSLVRMSSSMDFFCQVYFLLNRMIVILQ 150  fruit fly
XP_003294299  102 NQARILKETAESkfYQPLTVFGE-------------ITGE--------SSEGDVQIEVGKLLPFMIDLSAFVNRCYSLIR 160  Dictyostelium...
XP_009021212   75 IEIQTLEREAVEnfYLQLIFYGE----------GD-EHAE--------KQDGDIHLQIGRMLPILVGLYKYVGRCTDVLR 135  Helobdella ro...
XP_002431643   92 MEVKERREEGYSkfCNALLKYGE-------------ECSN--------DDEKILHITISNYLPLFQDLYCFVNRCHQIVI 150  human body louse
XP_011258277   88 REIRLLKVEAAGf-YTKLFTHGE---------------RC--------ADDDFPITNVTKLLSDLQDLSIFANRMSTVVH 143  Florida carpe...
XP_001602448   88 REIRLLKAEANk-fYEKLFSHGE---------------RC--------ADQEG--YKMENLLSDLQDLSIYTNRIYTVVH 141  jewel wasp
XP_008199002   92 EEINLLVEEARTy-YPVFVFYGE----------GK-------------NSTKEDLKSISSVVEVLQKVSCFIERCYHVIA 147  red flour beetle
XP_624277      88 REIRLLVMEAKTf-YKKLFTHGE----------KG-TENN--------------QNNITSLLSDLQDLFVFVNRIWTVTH 141  honey bee
XP_001355110   91 NQCRDLSLTAKQ--YQLAFLFND----------SQ-LGDGrlpavsdtAGLERCLHRMSSAIDFFCQVYFLLKRIIVMVQ 157  Drosophila ps...
XP_002067587   85 NQCHDLTTALKQ--YQLAFSFGD----------FQ-IDEG---------GIEQTLHRMSSAIDFYCQVYFVLKRSIVILQ 142  Drosophila wi...

Q9VXH9        151 NLWRQIAASVSV------PMD--IN-----EVHIFAVFDAMSELLEHIVVFNEL-ANQSKISTMWALYKKWLMNLSNSQS 216  fruit fly
XP_003294299  161 NIISQFASIYQN------QKN--IHtqffkNVHLQTVYYSMIDVFSVLVTLDSIiTQNTALNSSWGRYLRMVKSVRQEPG 232  Dictyostelium...
XP_009021212  136 NCLLQLCIFYTNesasirSMD--IS-----GSNLTVVYEHIGQLMHHLAVLDHViDNQTLLKEHWKMYKRMIKSVYSSPE 208  Helobdella ro...
XP_002431643  151 EIIKQLAAIYTTsdk-nlTIN--SM-----NVHFEDMMDHLGEILTILVTLDRLiESIDNISEGWSLYKRLIRTVQLNv- 221  human body louse
XP_011258277  144 LTTQQLASLSGA-----------VH-----EIYLPTLIEGFIDLFVIFMILDEIiDAQPTIVDQWKKYRMHVRSVMHNPS 207  Florida carpe...
XP_001602448  142 LTVRQLSSLANS------S----HR-----EIYLPLLIEHLMDLFVILVTLDELiSNQSALAEQWKVYRVKVRSVLHNAA 206  jewel wasp
XP_008199002  148 LLFQQLCAILGK------EYNtiRS-----GTCFPELLDCLAELLVCLLTFDSLfSNQTLLKDHWLLYWRSVKGILHNPG 216  red flour beetle
XP_624277     142 LTTEQLSNLAS---------D--SN-----DVYLPVLIEHFIDLFIIVLTLDEIvESQPSLQEQWKKYRMNVHSIMHNPS 205  honey bee
XP_001355110  158 TLWKQISASGSM------PLE--IS-----EVHLFTVFDAMTELLEDVVVFNEI-SDQSKIAAKWTLYKKWLAALSNSKQ 223  Drosophila ps...
XP_002067587  143 NLWNQISASVCL------PVD--IG-----EVHLFTTFDSICELLEQIVIFNEI-SMQSNMSEKWTLYKKWLKNLDKSKA 208  Drosophila wi...

Q9VXH9        217 -------AnL-ELNGLSTSLMDIE-NLITKDFFRILLDNLM-------ELKKQFGLNSvspitqHSNAYIRRQLLDVDA- 279  fruit fly
XP_003294299  233 kys--vqEdE-KLWQLEKLLLSLKgQLLEGFIFQTCITQEFdfp-gviEVKSNKVLKQ------EFCYNVKLLFGLLSAk 302  Dictyostelium...
XP_009021212  209 svk--vnS-D-QMQQFIVMLNRVDnVVMQGSMFQTCINQKFeepefsiNVSTNKHFSD------ECMAAVKELWSRVDQk 278  Helobdella ro...
XP_002431643  222 ------iP-E-KLSMLENITKTLEsNLLSGKIFHNMLEKLSqi----sQIVRQSKLGD------EFLLYLKNMLTRLEGk 283  human body louse
XP_011258277  208 qfg--iaE-A-KLETFDHLLKDLQeKLLRRNMFLKAIEHVMd-------VNKGLVMSE------QIVSYLKNTITDVETk 270  Florida carpe...
XP_001602448  207 qln--ipE-A-RILTYEKLLKDLHvQLLSKNLFLKAIEHVMd-------VNKSTTMCD------HMLCFLKNTITDVESk 269  jewel wasp
XP_008199002  217 kfq--ltR-E-QVRSLDKNLASIDnTLLTGNIFKTALEKCLdek--viLVMKNSSLSN------EISAYINQLLTELER- 283  red flour beetle
XP_624277     206 qfg--inE-S-KLHVFNKLLKDLQeNLLKKVLFSKTIESVMd-------VNKGPIMSE------HITNYLKNLIIDIENk 268  honey bee
XP_001355110  224 tsd--qcSsM-ELNGLLTSLDDIE-TVITGNLFGILLNSLL-------ELKKQFTLKDinhinqHSNAYIRKIMLEIEAn 292  Drosophila ps...
XP_002067587  209 ndltglyT-KlEIGGLYASLDDLE-TVISGNIFRILLDSLL-------ELKKQFNLKDvnhltqHSNAYTRKLQLEIESr 279  Drosophila wi...

Q9VXH9        280 ---NPSNELknyEDPKHIIRLTTFVVVVHELGI-QMEGKLVKNVIDLVARHKQVPLNRSVFWSPSGFLSLHAKTLMK--S 353  fruit fly
XP_003294299  303 --iMDSSEL---NLRERFPGFLGLYVFYISLFKdITDKSFFKLVWEITKRVPMVSIYANVFWFSGDFIQTLLPGMIK--I 375  Dictyostelium...
XP_009021212  279 --iGEVSEM---NERARLIGVLCLFVLHQSVFQ-SQDKKMFKTLFDVHKKIPCLVLTGSSVFYPSEFLARMLPKLNQm-V 351  Helobdella ro...
XP_002431643  284 --dLDMNQMmmnHQEKLWSKVICLFVLNTYLFG-LHDKKLLKQIWEVSKKNVCINLFKNIIWFPDDFLFQHLSHIFK--A 358  human body louse
XP_011258277  271 --sNDYAAL---N--KNWIRANVGIVVVIKLFG-ACDRRLIKRVLETNKRFYAVTLVGNVIWVPSRFLSNIVPKE----- 337  Florida carpe...
XP_001602448  270 --iNDNAAI---N--KNWIQVNVGIVVLIKLFG-TCDKKLLKRIVEVNKKLYAVTLVGNIVWLPNDFLVDCLPRE----- 336  jewel wasp
XP_008199002  284 ----DEENI---FFTQVWLQVNCLVVLEHCLFG-STDKKLVKRLIEVNKKASACTLCGNVLWYPEQFLLKHVPSLSK--F 353  red flour beetle
XP_624277     269 --pNDYVSL---N--KNWIEINIGIVIITKLFG-TCDKRLIKRVLENNKKFYAVNLIGNIIWIPSKFLSDFLPKEA---- 336  honey bee
XP_001355110  293 h-gNDYKNY---EDPKNVIRLTALVAVLHELGI-QMEGKLIKSVLDVASRHKRLALNQSVCWSPSAFLARHAKTLIKtpP 367  Drosophila ps...
XP_002067587  280 hqaNEYRNY---EEPKHIIRLTAFVAILYQLGI-QIEGKLMKHLLETLSKYHRLPINQNVHWSPNVFLMQHAKSLIR--T 353  Drosophila wi...

Q9VXH9        354 SARSQDGQGPKVHSTVLEKFRLSDQRTCRQLGVQLSLWSIQMQ-----RVF----------DVGVFGHLKTFLQLILNGH 418  fruit fly
XP_003294299  376 VGNPN---IMELRKEYLKTVDKEFAPRVKSYYLQVSRWMVRMEssiarTS--------------HWDASLSKVNQIIQGV 438  Dictyostelium...
XP_009021212  352 VDKKTLQAMESAKLLNLQKMVQCLNLQLPAFEAGLAQWIVKLEgylmsLPSsltsssvqlsDPRFNEELIEKCKLLQQGL 431  Helobdella ro...
XP_002431643  359 DDKKQKQSIVNLRNEHLNQKDANLFNQVQKYLQETCLWVIQLNsvlkkDK-----------GNLILDELKEKCKLFLAGS 427  human body louse
XP_011258277  338 ---TGTAASPQIGEKILQARTQRLPTIVNNLIHRATTWCVEMQsiltrTNL-------------QVSDIGQKRTLLMDLL 401  Florida carpe...
XP_001602448  337 ---GITAIPTQVGEKLLTGRIQRLPLVVSNLIQRAMMWGIEMQtllikTGL----------Q--IFSEIERKRNLLIEIL 401  jewel wasp
XP_008199002  354 LDEKT---FDNIRLAKIALRSQNLPKETHLLSLQACHWMIEIDri-tqRNL----------TSFDVKHLHETSNLLIDGI 419  red flour beetle
XP_624277     337 ----GNTINQQVGEKILCSRIQKLSQTVNSLIQKAVTWCIDMQsilmkTSL-------------QISDIGQKQSLLVDLV 399  honey bee
XP_001355110  368 QAKPQDNH--KSHHALMEKTKLSDQKKCRHLGTQICLWTIHVQ-----RVF----------AAGVFGKLQTFSQLILRGQ 430  Drosophila ps...
XP_002067587  354 PGNKVPTSL-QPNAVSLEKIKQNDQRACRQLGTQIAIWSLNMQ-----RVF----------AAGIFGHLKSFSELILSGQ 417  Drosophila wi...

Q9VXH9        419 SYADQVNLLAVALINRHVALMTPMTRNDWIVVSRLLQYLKVIQKTFESNQINFVRFISSLIQWQKQKVIHLLHTTKKKI- 497  fruit fly
XP_003294299  439 VLSYHISHLLKTMIGLHMNLTAPLKPSDVRKLFQCAEMLKSIQNTFHRRSAMISAHISMMVQQLTDIINEKLNVVRAKYs 518  Dictyostelium...
XP_009021212  432 IQSFYLRNTSATLLTTHATLNRPMTKSLVNNICHVVEMLKVIEGSWYRFSIQVVNTASYLVQYFSLLMAVVISNANKRVr 511  Helobdella ro...
XP_002431643  428 KLASDMSRVLKTVLNLHTALSKPMTKATVLYLCKLIELLKSIEMIYQNYYFFMCEPLNHIRQYLAYLALNTIKNAKSRIl 507  human body louse
XP_011258277  402 ALLSQMRETVAFVTNLHASLSKPMSRNTVQFICRIIELQKSLQTTFYALGPIVVQSQAQVLQYLAYYILAMLETARKGLv 481  Florida carpe...
XP_001602448  402 LLMRQIRENVSFVTNLHAFLLKPMSRSTVQLICRLIEVQKSLETTFYTLASTVVLSQSQVLQQLTYQILTILETVRKSLt 481  jewel wasp
XP_008199002  420 KLIKKISEVVKWITNLHADKDRPMAKSVLLSLCRLVEILKCFQFIFHKKLQPLVYIISLILQHLSHKALTLLRNIRKSLt 499  red flour beetle
XP_624277     400 ALLSQIKEIISFIINMHAILIKPMNRNTVQLICRLIEVQKSLQTTFYILGPVIVQSQSQVLQYLSYYILITLETARKSLi 479  honey bee
XP_001355110  431 SYADQVNLMMDALINRHVALTTPLSKSEWFTVCRLLQYLRVLQKTFESNEINVMRLINSLVQWQKQKVFHLLLSTKRKI- 509  Drosophila ps...
XP_002067587  418 SYADQVAGHIEGLVNRHVALMVPLTKTDFYTICKLMQYLKVIHHTFASNQISFIRFLSSLSQWQKQKVLHLLLTTKKKI- 496  Drosophila wi...

Q9VXH9        498 V-VLKLLQRKINFLATIKLAEKSIMGFPSKQRLTFVNLALGeF-L-DNRLLPADNQKLIKSILHRVNSISDIMRNIGGQ 573  fruit fly
XP_003294299  519 G-RTNYSEIELDVIVALSLVSDLLCGVATPERITVIRLCLN-V-IyQSNALKEQEIEELRLHIKRLEFISDLGSIIKSS 594  Dictyostelium ...
XP_009021212  512 G-DKKV---RPEVLSAFELMLQCLAGPMTNERILAMKLALG-F-CvKNKAFKDDELVSIRVYLEDIDRFTNFKTLIQES 584  Helobdella rob...
XP_002431643  508 S-DKSYTKKHLDTLSALVLSEKVLLGPVTVERCLIARLGLSiArGnASKALKDEEVEQIYLNLQLLNKICLLQKTVTES 585  human body louse
XP_011258277  482 QkDKGYSRERLDALSLVGLGMRLISGPASADRRLIVRCTLAcA-SqLTDTFREEDVVKLRFLLDSYDAVAELHELVDEL 559  Florida carpen...
XP_001602448  482 QkDKSYSRERLDALSLIGSSMRLINGPATADRRLILRCALVcA-SqLTESFKEEEVVKLRYYLDTYDTIVELYDLVLEt 559  jewel wasp
XP_008199002  500 Q-EKSYKEQQLDVLSALNVCEQNLKGPNTNQRILIAKLSLS------ASGLSCDHLTEIRSVINRLELICCVHSILNRL 571  red flour beetle
XP_624277     480 QkDKGYSKEKLDSLSLVGLSMRLLNGPPSADRRLIIRCALAcA-NqLTDTFKEEDMVKLRFSLNNYDIIAELHNIIIDL 557  honey bee
XP_001355110  510 V-DLKLLQRKMNILSTIKLAERSILGFPSKKRLTFVNLALSeF-LeKDRLLPVDMQRQFQSILLRINNLSDFQRNIKGQ 586  Drosophila pse...
XP_002067587  497 V-DLKLLQRKMNILSSLKLTEKSLRSHPVRRRLTVINLALSeF-LeKDRSLPADKQKLFKSIYQRANNLGDIQRNISGQ 573  Drosophila wil...
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